The major cyanogenic glycoside in thalictrum aquilegifolium

Aspects on the Biosynthesis of the Cyanogenic Glucoside Triglochinin inTriglochin maritima1

“…ties of 3a and 5 are low for the two amino acids as precursors whereas 2 is incorporated fairly well as has already been observed (4,5). Recently it has been shown that 2 is not channelled in the in vitro biosynthesis of 3a by microsomes isolated from T. maritima (24), which explains the relatively good in vivo incorporation of 2.…”

“…This view has led to the plausible suggestion that an aromatic cyanogenic glucursor of 5 (7,1). This hypothesis is supported by the occurrence of 3a, 3b or 4-glucosyloxymandelonitrile and its glucoside together with 5 orits methylesterin severalplants (5,8,9,10,11, gether with 5 or its methylester in several plants (5,8,9,10,11,12). The few biosynthetic studies which have been performed show that 1, 2, 4-hydroxymandelonitrile and 3,4-dihydroxymandelonitrile are incorporated into 5 and that 2 is by far the best substrate (4,5).…”

“…Dieffenbachia spp.) contain triglochinin as the gests a biosynthetic origin from a ring cleaved aromatic system (3) and some authors have observed the incorporation of tyrosine (1) into 5 (4) or its monomethylester (5). These data not only establish an aromatic precursor for 5, but suggest that 5 is synthesized by the established pathway for this class of compounds (6) involving hydroxylation and glucosylation (i.e.…”

“…The cyanogenic glucoside triglochinin (5), first isolated from Triglochin maritima L., is widely distributed in the plant kingdom. Thus, several medicinal plants (i.e.…”

Natural products from medicinal plants: non-alkaloidal natural constituents of the Thalictrum species

“…Traces of 5-transpentadecenoic acid (107) and 5-trans-heptadecenoic acid (109) were also detected. Moreover, Bhatty et al found fatty acids having only a cis-double bond (111-115, 117, 119) as well as other saturated acids (99)(100)(101)(102)(103)(104)(105)(106). Thus, T. venulosum oil has been studied with more detail than any other species of Thalictrum.…”