The Maine Womenʼs Health Study

Carlson, Karen J.; Miller, Buell A.; Fowler, Floyd J.

doi:10.1097/00006250-199404000-00013

Cited by 182 publications

(21 citation statements)

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“…We used response options ranging from “big problem” to “no problem” because previous studies measuring similar quality of life concepts have found that patients can easily report the extent to which a particular symptom is problematic in their lives. (11, 12) Frequency calculations revealed that when limiting dyspareunia to responses including “medium problem” and “big problem”, the rate of dyspareunia at 6 months was 21.2% of those who were sexually active, which was comparable to prior studies. (1–3) When including those with a “small problem”, “medium problem”, and “big problem”, the rate rose to 54.1%, considerably higher than reported in prior studies.…”

Section: Methodssupporting

confidence: 77%

Risk Factors for Dyspareunia After First Childbirth

Alligood-Percoco

Kjerulff

Repke

2016

Obstetrics &Amp; Gynecology

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Objective To investigate risk factors for dyspareunia among primiparous women. Methods This was a planned secondary analysis, using data from the 1 and 6 month postpartum interviews of a prospective study of women who delivered their first baby in Pennsylvania, 2009 to 2011. Participants who had resumed sexual intercourse by the 6 month interview (n = 2,748) constituted the analytic sample. Women reporting a big or medium problem with painful intercourse at 6 months were categorized as having dyspareunia. Multivariable logistic regression was used to evaluate the effect of patient characteristics, obstetric and psychosocial factors, and breastfeeding on dyspareunia. Results There were 583 women (21.2%) who reported dyspareunia at 6 months postpartum. Nearly a third of those breastfeeding at 6 months reported dyspareunia (31.5%), versus 12.7% of those not breastfeeding (adjusted odds ratio (adjusted OR) 2.89, 95% confidence interval (CI) 2.33–3.59, P < .001); 32.5% of those reporting a big or medium problem with perineal pain at 1-month reported dyspareunia at 6 months versus 15.9% of those who did not (adjusted OR 2.45, 95% CI 1.93–3.10, P < .001); 28.3% of women who reported fatigue all or most of the time at 1 month reported dyspareunia at 6 months versus 18.0% of those who reported fatigue less often (adjusted OR 1.60, 95% CI 1.30–1.98, P < .001); and 24.1% of those who scored in the upper third on the stress scale at 1 month reported dyspareunia at 6 months postpartum, compared to 15.6% of those who scored in the lowest third (adjusted OR 1.55, 95% CI 1.18–2.02, P = .001). Conclusion In this prospective cohort study we identified specific risk factors for dyspareunia in primiparous women that can be discussed at the first postpartum visit, including breastfeeding, perineal pain, fatigue and stress.

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Section: Methodssupporting

confidence: 77%

Risk Factors for Dyspareunia After First Childbirth

Alligood-Percoco

Kjerulff

Repke

2016

Obstetrics &Amp; Gynecology

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“…In a study confined to women whose uteri were ≥8 weeks gestation, 25% of cases had surgery within one year of diagnosis [213]. In a study of cases with a broader range of uterine sizes, approximately 26% had surgery within 5 years; risk of progressing to hysterectomy was inversely related to recommended therapeutic use of OCs or progestins [214].…”

Section: Etiologic Hypotheses and Risk Factorsmentioning

confidence: 99%

Epidemiology of Uterine Fibroids

Wise

Laughlin-Tommaso

2016

Clinical Obstetrics &Amp; Gynecology

269

122

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Uterine leiomyomata (UL) have a substantial impact on women's health, but relatively few studies have identified opportunities for primary prevention of these neoplasms. Most established risk factors are not modifiable, including premenopausal age, African ancestry, age at menarche, and childbearing history. The main challenge in studying UL is that a large proportion of tumors are asymptomatic. Herein, we review the epidemiology of UL from published studies to date. We highlight the advantages of ultrasound screening studies and the ways in which their innovative methods have helped clarify the etiology of disease. We conclude with a discussion of promising new hypotheses.

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“…They are the number one cause of hysterectomy in reproductive-aged women, accounting for >200,000 of these surgeries annually in the United States alone (127) at an estimated cost of $1.7 billion per year. In addition, they are a significant cause of pelvic pain, menorrhagia, abnormal uterine bleeding, infertility, and complications of pregnancy including placental abruption (128-133). Therefore, the fact that these tumors do not metastasize beyond the uterus belies the extent of their negative impact on women’s health (132).…”

Section: Disruptions Of the Ovarymentioning

confidence: 99%

Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing

Crain

Janssen

Edwards

et al. 2008

Fertility and Sterility

394

233

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Objective To evaluate the possible role of endocrine-disrupting compounds (EDCs) on female reproductive disorders emphasizing developmental plasticity and the complexity of endocrine-dependent ontogeny of reproductive organs. Declining conception rates and the high incidence of female reproductive disruptions warrant evaluation of the impact of EDCs on female reproductive health. Design Publications related to the contribution of EDCs to disorders of the ovary (aneuploidy, polycystic ovary syndrome, and altered cyclicity), uterus (endometriosis, uterine fibroids, fetal growth restriction, and pregnancy loss), breast (breast cancer, reduced duration of lactation), and pubertal timing were identified, reviewed, and summarized at a workshop. Conclusion(s) The data reviewed illustrate that EDCs contribute to numerous human female reproductive disorders and emphasize the sensitivity of early life-stage exposures. Many research gaps are identified that limit full understanding of the contribution of EDCs to female reproductive problems. Moreover, there is an urgent need to reduce the incidence of these reproductive disorders, which can be addressed by correlative studies on early life exposure and adult reproductive dysfunction together with tools to assess the specific exposures and methods to block their effects. This review of the EDC literature as it relates to female health provides an important platform on which women’s health can be improved.

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The Maine Womenʼs Health Study

Abstract: Many women with leiomyomas, abnormal bleeding, and chronic pelvic pain report improved symptoms over time with nonsurgical management. Hysterectomy remains an important alternative when conservative treatment fails.

Cited by 182 publications

References 0 publications

Risk Factors for Dyspareunia After First Childbirth

Risk Factors for Dyspareunia After First Childbirth

Epidemiology of Uterine Fibroids

Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing

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