The Magnitude of the Association between Human Papillomavirus and Oral Lichen Planus: A Meta-Analysis

Ma, Jianxun; Zhang, Jinshan; Zhang, Yan; Lv, Tingting; Liu, Jie

doi:10.1371/journal.pone.0161339

Cited by 32 publications

(39 citation statements)

References 33 publications

(64 reference statements)

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“…25 In a recent meta-analysis which studied the immensity of the relation between HPV and OLP showed that OLP patients have significantly higher HPV prevalence (OR: 6.83; 95% CI: 4.15-11.27) than healthy controls. 26 Furthermore, it was observed that in the subgroup surveys, the association of HPV and OLP varied significantly according to the geographic region and population, among the 12 countries, in different continents. In the above-mentioned study, the ORs of HPV/OLP association were reported to range from 1.00 to 138.05.…”

Section: Discussionmentioning

confidence: 97%

“…In the above-mentioned study, the ORs of HPV/OLP association were reported to range from 1.00 to 138.05. 26 The same meta-analysis investigated the association between HPV and the clinical forms of OLP (erosive-atrophic (EA) and non-EA) which was comparable and more intense in the EA OLP lesions (OR: 9.34) than in the non-EA OLP lesions (OR: 4.32). 26 In addition, in a previous study, the risk of progression to oral malignancy for non-EA OLP lesions was approximately 0.5%, whereas in the EA OLP, lesions increased at least to 3.5-4.00% during similar follow-up periods.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of HPV screening methods and sample storage in oral lichen planus lesions

Poulopoulos

Hempel

Karakitsos

et al. 2017

Translational Research in Oral Oncology

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Aim: We investigated the human papillomavirus (HPV) DNA distribution in oral lichen planus (OLP) samples using non-invasive methods, with the potential for much broader population screening.Methods: Three different non-invasive collection methods (dry storage, lysis buffer preservation, and use of a commercial tool to rake epithelial cells and immersion of the collection device into the provided rinse solution) were evaluated. HPV DNA was detected in brushed or scraped samples of the lesion site using a commercial HPV DNA polymerase chain reaction kit. Results: In the group of patients with OLP lesions, HPV was detected significantly more frequently than in the healthy control group (lysis buffer for control ¼ 2.1%, p ¼ 0.046; DNASAL™ rinse solution for control ¼ 4.2%, p ¼ 0.0003; dry storage for control ¼ 6.3%, p ¼ 0.0001) regardless of the different collection and preservation methods. HPV DNA was detected in 12.85% of the samples preserved in lysis buffer. HPV DNA was detected in 34.28% (p ¼ 0.0048 vs. lysis buffer) of samples preserved in the DNASAL rinse solution. In the case of dry storage, HPV DNA was detected in 38.57% (p ¼ 0.0008 vs. lysis buffer and p ¼ 0.726 vs. DNASAL) of samples. Conclusion:The results suggest that the most effective sample preservation methods are provided by dry storage or DNASAL collection compared to lysis buffer. Our findings indicated that HPV DNA detection in superficial OLP scrapings has potential as a screening tool and has important applications for both research and clinical practice.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Assessment of HPV screening methods and sample storage in oral lichen planus lesions

Poulopoulos

Hempel

Karakitsos

et al. 2017

Translational Research in Oral Oncology

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“…98 Interestingly, an association between OLP and viral infections has also been reported. A recent meta-analysis 100 showed that patients with erosive OLP have a higher risk of HPV infection (HPV-16 and HPV-18), suggesting a potential causal role in OLP progression. Similarly, a possible association with HCV has also been reported.…”

Section: Oral Lichen Planusmentioning

confidence: 99%

Oral potentially malignant disorders: risk of progression to malignancy

Speight

Khurram

Kujan

2018

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

385

361

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Oral potentially malignant disorders (OPMDs) have a statistically increased risk of progressing to cancer, but the risk varies according to a range of patient- or lesion-related factors. It is difficult to predict the risk of progression in any individual patient, and the clinician must make a judgment based on assessment of each case. The most commonly encountered OPMD is leukoplakia, but others, including lichen planus, oral submucous fibrosis, and erythroplakia, may also be seen. Factors associated with an increased risk of malignant transformation include sex; site and type of lesion; habits, such as smoking and alcohol consumption; and the presence of epithelial dysplasia on histologic examination. In this review, we attempt to identify important risk factors and present a simple algorithm that can be used as a guide for risk assessment at each stage of the clinical evaluation of a patient.

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“…Since the first report of the detection of HPV DNA in OLP biopsies, many groups have investigated the presence of HPV in oral tissues or exfoliated cells from patients with OLP and control subjects by polymerase chain reaction (PCR), immunohistochemistry, or in situ hybridization, but conflicting results have been reported. A recent meta‐analysis of 22 case–control studies concluded that patients with OLP have a significantly higher risk of HPV infection than healthy controls (35.09% vs 7.77%, odds ratio [OR] 6.83, 95% confidence interval [95% CI] 4.15‐11.27), with the variation depending on geography, clinical types of OLP, and HPV genotype …”

Section: Association With Viral Infectionmentioning

confidence: 99%

The microbiology of oral lichen planus: Is microbial infection the cause of oral lichen planus?

Baek

Choi

2017

Molecular Oral Microbiology

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SummaryOral lichen planus (OLP) is a variant of lichen planus (LP), a common chronic mucocutaneous inflammatory disease. Cutaneous lesions of LP are self-limiting, but OLP lesions are non-remissive, alternating periods of exacerbation and quiescence, and only symptomatic treatments exist for OLP. The precise etiology and pathogenesis of OLP are hardly understood, which is a major obstacle to the development of new therapeutics for this disease. OLP is considered a T-cell-mediated inflammatory disease.Although various antigens have been considered, what actually triggers the inflammatory response of T cells is unknown. Suggested predisposing factors include genetic factors, stress, trauma, and infection. The aim of this review was to determine whether microbial infection can cause OLP. We first reviewed the association between OLP and microbial factors, including viral, fungal, and bacterial infections. In addition, each microbial factor associated with OLP was assessed by modified guidelines of Fredricks and Relman to determine whether it establishes a causal relationship. In conclusion, no microbial factor yet fulfills the guidelines to establish the causality of OLP. By focusing on the unclarified issues, however, the potential roles of microbial factors in the pathogenesis of OLP will be soon elucidated. K E Y W O R D Sbacteria, causality, fungi, oral lichen planus, viruses | INTRODUCTIONLichen planus (LP), first described by Erasmus Wilson in 1869, is a common chronic mucocutaneous inflammatory disease affecting the skin, nails, eyes, urogenital tract, and oral mucosa.1 The prevalence of LP in the general population is 0.22%-5%. Although OLP is sometimes regarded as an autoimmune disorder, it is not classified as an autoimmune disease because no autoantigens have been identified. Suggested predisposing factors include genetic factors, stress, trauma, and infection. 5,6 In this article, microbial factors

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The Magnitude of the Association between Human Papillomavirus and Oral Lichen Planus: A Meta-Analysis

Cited by 32 publications

References 33 publications

Assessment of HPV screening methods and sample storage in oral lichen planus lesions

Assessment of HPV screening methods and sample storage in oral lichen planus lesions

Oral potentially malignant disorders: risk of progression to malignancy

The microbiology of oral lichen planus: Is microbial infection the cause of oral lichen planus?

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