The M235T polymorphism in the angiotensinogen gene and myocardial infarction risk: A meta-analysis

Wang, Yujing; Pan, Yan

doi:10.1177/1470320312471148

Cited by 11 publications

(14 citation statements)

References 30 publications

(33 reference statements)

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“…Besides, G‐6A and A‐20C mutations in AGT gene 5 'end can increase the transcription level of AGT gene and increase its gene expression, the mutations at the two sites were linkage imbalance with M235T, indicating that M235T may be only a genetic marker, G‐6A and A‐20C may be the direct cause of increased plasma AGT levels. We failed to demonstrate the genotype and allele distribution frequency of AGT gene polymorphisms (M235T, G217A, G152A, G‐6A, and A‐20C) between CAD and non‐CAD patients, although it has been reported that AGT gene M235T may be a susceptible factor for myocardial infarction in a Chinese population, which may be related to the difference of the subjects.…”

Section: Discussionmentioning

confidence: 99%

The relationship among angiotensinogen genes polymorphisms and hs‐CRP and coronary artery disease

Zhu

Lin

Wang

et al. 2019

Clinical Laboratory Analysis

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ObjectiveTo assess the association of gene polymorphisms of angiotensinogen (AGT), the key factor in rennin‐angiotensin‐aldosterone system (RAAS), with high‐sensitivity C‐reactive protein (hs‐CRP) and coronary artery disease (CAD).MethodsThe current study recruited the patients who were hospitalized and assessed by coronary angiography for suspected CAD. The patients with documented CAD served as CAD group (n = 492) while the patients without documented CAD (n = 87) served as control group. We compared laboratory data and CAD risk factors between the two groups. Furthermore, we analyzed the association of AGT M235T, G217A, G152A, G‐6A, A‐20C genotypes with coronary artery stenosis and in‐stent restenosis.ResultsThere were significantly differences between two patient groups in sex, smoking history, diabetes mellitus, carotid atherosclerosis, lower limb arteriosclerosis, hs‐CRP, blood glucose, and the level of high‐density lipoprotein (HDL; P < 0.05). In CAD group, hs‐CRP levels increased with increasing number of coronary artery branches (1, 2, or ≥3; P < 0.01), and Gensini integral was positively correlated with hs‐CRP levels (r = 0.361, P < 0.01). Frequencies of genotype and allele distribution in individual angiotensinogen loci (M235T, G217A, G152A, G‐6A, A‐20C) did not differ in two patient groups. Following stratification of patients according to hs‐CRP levels (<1 mg/L, 1‐3 mg/L, and >3 mg/L), the distribution frequency of allele M235T was statistically different among the groups (P < 0.05).ConclusionIn CAD patients, M235T among several AGT gene polymorphisms is associated with elevated hs‐CRP levels with AGT C allele as the significant factor for patients with hs‐CRP level of more than 1 mg/L.

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Section: Discussionmentioning

confidence: 99%

The relationship among angiotensinogen genes polymorphisms and hs‐CRP and coronary artery disease

Zhu

Lin

Wang

et al. 2019

Clinical Laboratory Analysis

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“…In addition, subgroup analysis based on ethnicity was used to investigate and interpret the diversity among the results of different studies. Sensitivity analysis was performed by using random effect values compared with the fixed effect in order to ensure the stability of the findings (16). Publication bias was investigated using Begg’s funnel plot and P<0.05 was considered to indicate a statistically significant publication bias.…”

Section: Methodsmentioning

confidence: 99%

Null genotypes of glutathione S-transferase μ1 and glutathione S-transferase θ1 are associated with osteosarcoma risk: A meta-analysis

et al. 2015

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Glutathione S-transferase (GST) genetic polymorphisms has been reported to be associated with osteosarcoma; however, the results of previous studies are conflicting. Thus, in the present study, a meta-analysis was conducted to investigate the effects of GSTM1 and GSTT1 polymorphisms on osteosarcoma risk. A literature search was performed in the PubMed, Cochrane Library and China National Knowledge Infrastructure databases to identify case-control studies published prior to March 2014. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. In addition, Begg’s test was used to measure publication bias. Sensitivity analysis were performed to ensure the accuracy of the results. The meta-analysis results demonstrated no significant association between the null genotype of GSTM1 and osteosarcoma risk (OR=0.83; 95% CI, 0.37–1.85). By contrast, the results revealed a significant association for the comparison of null vs. non-null genotypes of GSTT1 (OR=1.54; 95% CI, 1.09–2.19). In conclusion, the GSTT1 null genotype may be associated with an increased risk of developing osteosarcoma. Further studies with larger sample sizes and well-designed methodologies are required to verify these conclusions.

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“…Betweenstudy heterogeneities were estimated using the I 2 test. I 2 values of 25, 50, and 75% were defined as low, moderate, and high estimates, respectively (Wang and Pan, 2014). If a heterogeneity was found among the studies, the pooled OR was estimated using the fixedeffect model (P > 0.10 or I 2 < 50%).…”

Section: Discussionmentioning

confidence: 99%

Association of AGTR1 gene A1166C polymorphism with the risk of heart failure: a meta-analysis

Ja¹,

Li²,

Yj³

2015

Genet. Mol. Res.

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ABSTRACT. The aim of this study was to investigate the correlation between the A1166C polymorphism in the angiotensin II type 1 receptor (AT1R) gene and heart failure (HF) risk using meta-analysis. The PubMed database was searched, and data were extracted independently by two reviewers. Odds ratios (ORs) with corresponding 95% confi dence intervals (CIs) were used to assess the strength of the associations. Statistical analysis was performed using the STATA 12.0 software. The results of the metaanalysis showed no significant association between the AT1R A1166C polymorphism and HF risk (AA vs CC: OR = 0.72, 95%CI = 0.31-1.68; AA vs AC: OR = 0.78, 95%CI = 0.52-1.18; dominant model: OR = 1.37, 95%CI = 0.92-2.04; recessive model: OR = 0.73, 95%CI = 0.30-1.75). In the subgroup analysis by ethnicity, the results also showed no significant association between A1166C polymorphism and susceptibility to HF in both Caucasian and Asian populations. In conclusion, this meta-analysis suggests that the A1166C polymorphism in AT1R may not be associated with susceptibility to HF. J.A. Zhang et al. 9164©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (3): 9163-9170 (2015) Further large and welldesigned studies are needed to confirm these conclusions.

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The M235T polymorphism in the angiotensinogen gene and myocardial infarction risk: A meta-analysis

Cited by 11 publications

References 30 publications

The relationship among angiotensinogen genes polymorphisms and hs‐CRP and coronary artery disease

The relationship among angiotensinogen genes polymorphisms and hs‐CRP and coronary artery disease

Null genotypes of glutathione S-transferase μ1 and glutathione S-transferase θ1 are associated with osteosarcoma risk: A meta-analysis

Association of AGTR1 gene A1166C polymorphism with the risk of heart failure: a meta-analysis

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