Null genotypes of glutathione S-transferase μ1 and glutathione S-transferase θ1 are associated with osteosarcoma risk: A meta-analysis

Abstract

Glutathione S-transferase (GST) genetic polymorphisms has been reported to be associated with osteosarcoma; however, the results of previous studies are conflicting. Thus, in the present study, a meta-analysis was conducted to investigate the effects of GSTM1 and GSTT1 polymorphisms on osteosarcoma risk. A literature search was performed in the PubMed, Cochrane Library and China National Knowledge Infrastructure databases to identify case-control studies published prior to March 2014. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. In addition, Begg’s test was used to measure publication bias. Sensitivity analysis were performed to ensure the accuracy of the results. The meta-analysis results demonstrated no significant association between the null genotype of GSTM1 and osteosarcoma risk (OR=0.83; 95% CI, 0.37–1.85). By contrast, the results revealed a significant association for the comparison of null vs. non-null genotypes of GSTT1 (OR=1.54; 95% CI, 1.09–2.19). In conclusion, the GSTT1 null genotype may be associated with an increased risk of developing osteosarcoma. Further studies with larger sample sizes and well-designed methodologies are required to verify these conclusions.

Contribution of the GSTP1 gene polymorphism to the development of osteosarcoma in a Chinese population

“…For the reported association between GST gene polymorphisms and the development and prognosis of osteosarcoma (Li et al, 2014), two meta-analyses have further evaluated their correlations (Wang et al, 2015b;Han et al, 2015). Specifically, Li et al (2014) reported that the GG genotype of GSTP1 was significantly associated with overall survival of osteosarcoma in a Chinese population.…”

“…Wang et al (2015b) conducted a meta-analysis of six case-control studies, and did not find any association between GSTT1 polymorphisms and osteosarcoma risk. However, Han et al (2015) performed a pooled meta-analysis of three case-control studies, and their results revealed a significant association between the GSTT1-null genotype and risk of developing osteosarcoma. The results herein indicate that the GSTP1 gene polymorphism may affect osteosarcoma susceptibility in a Chinese population.…”

“…The etiology of osteosarcoma is not well understood, and it is reported that many environmental factors including ionizing radiation and a family history of osteosarcoma may contribute to the development of this cancer (Ottaviani and Jaffe, 2009). Previous studies have suggested that many gene polymorphisms may be involved in the development of osteosarcoma, such as those in the angiogenic growth factor genes VEGF, FGF2, ERCC1, ERCC2, and GSTs (Zhang et al, 2015a,b;Wang et al, 2015a;Jin et al, 2015;Han et al, 2015;Bian et al, 2015).…”

Association between XRCC3 Thr241Met polymorphism and risk of osteosarcoma in a Chinese population

“…Not all people exposed to similar risk factors develop osteosarcoma, however, which suggests that hereditary factors may influence susceptibility. Several previous studies have reported that gene polymorphisms play an important role in osteosarcoma, including variations in VEGF, FGF2, GSTs, NFKB1, RECQL5 and CTLA-4 genes (He et al, 2014;Zhi et al, 2014;Han et al, 2015;Li et al, 2015;Zhang et al, 2015;Wang et al, 2015).…”

Impact of common SNPs in VEGF gene on the susceptibility of osteosarcoma

“…The development of osteosarcoma is a complex, multistep, and multifactorial process, and many environmental and genetic factors play an important role in the carcinogenesis process (Bovee and Hogendoorn, 2010;Powers et al, 2010). Several studies have suggested that genetic factors are involved in the development of osteosarcoma, such as glutathione S-transferase, vascular endothelial growth factor (VEGF), interleukin factor, and DNA repair genes (Tang et al, 2014;Wang et al, 2014;Zhi et al, 2014;Han et al, 2015).…”