Association between XRCC3 Thr241Met polymorphism and risk of osteosarcoma in a Chinese population

Abstract

ABSTRACT. Osteosarcoma is one of the most common bone malignancies in adolescents, and hereditary factors may influence its susceptibility. We assessed the association between XRCC3 Thr241Met polymorphism and susceptibility to osteosarcoma in a Chinese population. Between May 2012 and May 2014, a total of 136 osteosarcoma patients and 136 healthy control subjects were included in our study. The XRCC3 Thr241Met polymorphism was analyzed using a polymerase chain reaction restriction fragment length polymorphism assay. By multiple logistic regression analysis, individuals carrying the Met/Met genotype of XRCC3 Thr241Met were at significantly increased risk of osteosarcoma when compared with the Thr/Thr (OR = 2.50, 95%CI = 1.13-5.66). The Thr/Met+Met/Met genotype of XRCC3 Thr241Met was furthermore found to be correlated with an elevated increased risk of osteosarcoma when compared with the Thr/Thr genotype (OR = 1.71, 95%CI = 1.03-2.87), and Met/Met genotype of XRCC3 Thr241Met was associated with an increased risk of osteosarcoma compared to the Thr/ Thr (OR = 3.50, 95%CI = 1. 51-8.79). In conclusion, our study firstly reports 16485 XRCC3 Thr241Met polymorphism and osteosarcoma risk ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 16484-16490 (2015) that XRCC3 Thr241Met gene polymorphism is associated with an elavated risk of osteosarcoma.

WITHDRAWN: Association between XRCC3 rs861539(Thr241Met) polymorphism and thyroid cancer risk (a Meta-analysis)

“…In the past decade, Numerous studies have investigated the potential biological signi cance of the XRCC-3 rs861539(Thr241Met) [28][29][30][31] , and it has been implicated as a causative risk factor for the development of different types of malignancies. The malignancy types included breast cancer [7,32,33] , lung cancer [34] , osteosarcoma [35] , melanoma [36] , thyroid cancer [14,16] . However, the correlation between XRCC3 rs861539 polymorphism and thyroid cancer risk still remained controversial [9,13,16,17] .…”

Epidemiological Evidence for Associations Between Genetic Variants and Osteosarcoma Susceptibility: A Meta-Analysis

“…The X-ray repair cross complementing 3 ( XRCC3 ) gene encodes a protein that repairs DNA damage and maintains chromosome stability. XRCC3 polymorphisms influence human cancer susceptibility by altering DNA repair efficiency ( 50 ). Our meta-analysis presented that XRCC3 rs861539 could increase OS susceptibility with strong evidence under the allelic model in Asians.…”