Singe nucleotide polymorphisms in osteosarcoma: Pathogenic effect and prognostic significance

Asnafi, Ali Amin; Behzad, Masumeh Maleki; Ghanavat, Majid; Shahjahani, Mohammad; Saki, Najmaldin

doi:10.1016/j.yexmp.2018.12.002

Cited by 16 publications

(8 citation statements)

References 125 publications

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“…1 However, for patient with metastasized OS, the 5-year survival rate is less than 30%. 2 Thus, finding new biomarkers and therapeutic targets is of great importance. Hint1 is a member of the histidine triad (HIT) enzyme superfamily, which was first described as a tumor suppressor.…”

Section: Discussionmentioning

confidence: 99%

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<p>Hint1 Overexpression Inhibits the Cell Cycle and Induces Cell Apoptosis in Human Osteosarcoma Cells</p>

Duan¹,

Xie²,

Shi³

et al. 2020

OTT

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Background: New evidence suggests that histidine triad nucleotide-binding protein 1 (Hint1) exerts a tumor suppressor effect in various human tumors, such as colorectal cancer and gastric cancer. However, it has not been reported whether Hint1 is involved in the occurrence and development of osteosarcoma (OS). Materials and Methods: The present study investigated the role of Hint1 in human OS cells by using cell lines, including 143B, U2OS, KHOS-240S, Saos-2 and MG-63. Cell proliferation and apoptosis were detected by flow cytometry. Results: The present result revealed that Hint1 is downregulated in these cell lines. The overexpression of Hint1 by adenovirus transfection in 143B and MG63 cell lines suppressed the proliferation and cell cycle, and increased the cell apoptosis. Mechanically, it was found that Hint1 downregulated the cyclin D1 expression via FOXO1 inhibition. Furthermore, FOXO1 overexpression in the 143B and MG63 cell lines significantly blurred the effects of Hint1 on cellular proliferation and apoptosis. Conclusion: The present study indicates that Hint1 inhibits the development of OS by regulating FoxO1-cyclin D1, suggesting that Hint1 may be a new method for the treatment of OS.

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Section: Discussionmentioning

confidence: 99%

“…1 The 5-year survival rate of OS patients is merely 60%. 2 The main therapeutic method of OS includes surgical resection combined with chemotherapy and radiotherapy. 3 Although scientists have been trying to search for new ways to treat OS in the past few decades, its progress has been slow.…”

Section: Introductionmentioning

confidence: 99%

<p>Hint1 Overexpression Inhibits the Cell Cycle and Induces Cell Apoptosis in Human Osteosarcoma Cells</p>

Duan¹,

Xie²,

Shi³

et al. 2020

OTT

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“… 3 , 71 , 72 Although flow cytometry is a practical technique to analyze the expression levels of CD markers, genetic alterations (including SNPs) affecting expression patterns of CD markers may cause significant limitations in the classification and precise prognosis of hematological malignancies. 73-75 As an example, CD38 rs6449182 is a known polymorphism in CLL and it has been shown that patients carrying the GG genotype of this polymorphism have more aggressive disease. 30 , 31 Although clinical symptoms such as BM, PB, and lymph node involvement are the most crucial prognostic factors in CLL, the CD38 rs6449182 SNP has been shown to be associated with biochemical abnormalities such as increased LDH and lipoproteins, which indicates the progression toward advanced clinical stages.…”

Section: Discussion and Future Perspectivementioning

confidence: 99%

CD markers polymorphisms as prognostic biomarkers in hematological malignancies

et al. 2020

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The clusters of differentiation (CD) are surface molecules used for immunophenotyping of cells. The expression of CD markers is widely used to classify hematological malignancies, including leukemia and lymphoma. Single nucleotide polymorphisms (SNPs) are crucial genetic changes that can be associated with abnormal expression and function of CD markers. In this paper, we assess the prognostic effect of CD markers’ SNPs in hematological malignancies. Materials and methods and relevant literature was identified by a PubMed search (2001-2019) of English language papers using the following terms: ‘polymorphism’, ‘CD marker’, ‘leukemia’, ‘lymphoma’, ‘prognosis’, ‘CD marker’, and ‘polymorphism’. Many studies have demonstrated the effects of CD markers’ polymorphisms on risk of hematological malignancies. Also, SNPs of CD markers can be related with clinicopathological features, invasiveness, and response to therapy of these disorders. Considering the importance of SNPs in the expressions of CD markers, these genetic changes could be used as potential prognostic biomarkers in hematological malignancies. It is hoped that the evaluation of SNPs in CD markers will enable early diagnosis, prognosis, and detection of response to treatment. However, better understanding of SNPs in CD markers that are involved in hematological malignancies requires further studies on different populations of the worldwide.

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“…Cancer is a disease that affects the entire world, and osteosarcoma is the most common malignant bone tumor (Asnafi et al, 2019). The main strategies to block and delay carcinogenesis are as follows: (a)…”

Section: Introductionmentioning

confidence: 99%

The role of dietary polyphenols in osteosarcoma: A possible clue about the molecular mechanisms involved in a process that is just in its infancy

Rabêlo

Borghesi

Noratto

2021

Journal of Food Biochemistry

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Osteosarcoma (OS) is a primary malignant bone tumor mainly affecting children, teenagers and young adults, being associated with early metastasis and poor prognosis.The beneficial effects of polyphenols have been investigated in different areas, including their potential to fight OS. Polyphenols are believed to reduce morbidity and/ or slow down the development of cancer. This review aimed to assess the effect of polyphenols in OS and investigate their molecular mechanisms. It was observed that the broad spectrum of health-promoting properties of plant polyphenols in OS occurs mainly due to modulation of reactive oxygen species, anti-inflammatory activity, anti-angiogenesis, apoptosis inducer, inhibition of invasion and metastasis. However, it is worth mentioning that although the promising effects of polyphenols in the fight against OS, most of the studies have been performed using in vitro and in vivo animal models. Therefore, studies in humans are needed to validate the effectiveness of polyphenols in OS treatment. Practical applicationsPolyphenols are widely used for various diseases, however, until now, their real role in the treatment of osteosarcoma remains unknown. This review provides a broad spectrum of research conducted with polyphenols and their potential as adjuvant therapy in the treatment of osteosarcoma. However, prior to their clinical application for osteosarcoma treatment, there is a need to isolate and identify specific polyphenolic compounds with high antitumor activity, increase their oral bioavailability, and to investigate their interactions with chemotherapeutic drugs being used in clinical practice.

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Singe nucleotide polymorphisms in osteosarcoma: Pathogenic effect and prognostic significance

Cited by 16 publications

References 125 publications

<p>Hint1 Overexpression Inhibits the Cell Cycle and Induces Cell Apoptosis in Human Osteosarcoma Cells</p>

<p>Hint1 Overexpression Inhibits the Cell Cycle and Induces Cell Apoptosis in Human Osteosarcoma Cells</p>

CD markers polymorphisms as prognostic biomarkers in hematological malignancies

The role of dietary polyphenols in osteosarcoma: A possible clue about the molecular mechanisms involved in a process that is just in its infancy

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