The M. D. Anderson proton therapy system

Smith, Alfred R.; Gillin, Michael; Bues, Martin; Zhu, Xiaorong Ronald; Suzuki, Kazumichi; Mohan, Radhe; Woo, Shiao Y.; Lee, Andrew; Komaki, R.; Cox, James D.; Hiramoto, Kazuo; Akiyama, Hiroshi; Ishida, Takayuki; Sasaki, T.; Matsuda, Koji

doi:10.1118/1.3187229

Cited by 170 publications

(162 citation statements)

References 18 publications

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“…Nevertheless, one of the limitation of this study is that the beam delivery time is estimated based on a single room system, as a result the room switching time and waiting time from a multiroom proton center were not estimated. Hence, additional time is needed to be added to compensate the difference between the single room and multiroom system system 16. In a busy multiroom center, IMPT with eight beam angles might still not be practically feasible due to the long waiting time.…”

Section: Discussionmentioning

confidence: 99%

Redefine the role of range shifter in treating bilateral head and neck cancer in the era of Intensity Modulated Proton Therapy

Ding

Qin

et al. 2018

J Applied Clin Med Phys

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Section: Discussionmentioning

confidence: 99%

Redefine the role of range shifter in treating bilateral head and neck cancer in the era of Intensity Modulated Proton Therapy

Ding

Qin

et al. 2018

J Applied Clin Med Phys

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“…Technical details of the proton therapy system used in this report have been described in a previous report (26) . The components along the beam path (Fig.…”

Section: Methodsmentioning

confidence: 99%

Spot scanning proton therapy minimizes neutron dose in the setting of radiation therapy administered during pregnancy

Wang

Poenisch

Zhu

et al. 2016

J Applied Clin Med Phys

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This is a real case study to minimize the neutron dose equivalent (H) to a fetus using spot scanning proton beams with favorable beam energies and angles. Minimum neutron dose exposure to the fetus was achieved with iterative planning under the guidance of neutron H measurement. Two highly conformal treatment plans, each with three spot scanning beams, were planned to treat a 25‐year‐old pregnant female with aggressive recurrent chordoma of the base of skull who elected not to proceed with termination. Each plan was scheduled for delivery every other day for robust target coverage. Neutron H to the fetus was measured using a REM500 neutron survey meter placed at the fetus position of a patient simulating phantom. 4.1 and 44.1 44.1 μSv/fraction were measured for the two initial plans. A vertex beam with higher energy and the fetal position closer to its central axis was the cause for the plan that produced an order higher neutron H. Replacing the vertex beam with a lateral beam reduced neutron H to be comparable with the other plan. For a prescription of 70 Gy in 35 fractions, the total neutron H to the fetus was estimated to be 0.35 mSv based on final measurement in single fraction. In comparison, the passive scattering proton plan and photon plan had an estimation of 26 and 70 mSv, respectively, for this case. While radiation therapy in pregnant patients should be avoided if at all possible, our work demonstrated spot scanning beam limited the total neutron H to the fetus an order lower than the suggested 5 mSv regulation threshold. It is far superior than passive scattering beam and careful beam selection with lower energy and keeping fetus further away from beam axis are essential in minimizing the fetus neutron exposure.PACS number(s): 87.53.Bn, 87.55.D‐, 87.55.N‐

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“…The Hitachi delivery system contains helium chambers at the beam pass (6,7,9). To minimize beam scattering in air, a vacuum inside the nozzle is assumed.…”

Section: Beam Nozzle Layout Modelsmentioning

confidence: 99%

“…The characteristics of the beam entering the nozzle were set to mimic currently achievable beam parameters (7,9,10,16). …”

Section: Proton Beam Characterizationmentioning

confidence: 99%

“…However, it should be pointed out that even the smallest achievable diameter of a scanning beam is not capable of delivering an optimum dose distribution at every spatially located target volume (8). With currently available beam shaping technology, beam diameters as narrow as 1.2 cm full width half maximum (FWHM) are achievable and state-of-the-art proton delivery systems dedicated for spot-scanning have demonstrated that beam diameters vary from 1.2 cm at 221.8 MeV to 3.4 cm at 72.5 MeV in air (6,9). It has been shown recently that spot sizes (FWHM) of 1.1 cm for 140 MeV and 0.68 cm for 226.7 MeV in air are realistically achievable with the novel IBA pencil beam system (10).…”

Section: Introductionmentioning

confidence: 99%

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Effect of Scanning Beam for Superficial Dose in Proton Therapy

Moskvin

Estabrook

Cheng

et al. 2014

Technol Cancer Res Treat

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Proton beam delivery technology is under development to minimize the scanning spot size for uniform dose to target, but it is also known that the superficial dose could be as high as the dose at Bragg peak for narrow and small proton beams. The objective of this study is to explore the characteristics of dose distribution at shallow depths using Monte Carlo simulation with the FLUKA code for uniform scanning (US) and discrete spot scanning (DSS) proton beams. The results show that the superficial dose for DSS is relatively high compared to US.Additionally, DSS delivers a highly heterogeneous dose to the irradiated surface for comparable doses at Bragg peak. Our simulation shows that the superficial dose can become as

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The M. D. Anderson proton therapy system

Cited by 170 publications

References 18 publications

Redefine the role of range shifter in treating bilateral head and neck cancer in the era of Intensity Modulated Proton Therapy

Redefine the role of range shifter in treating bilateral head and neck cancer in the era of Intensity Modulated Proton Therapy

Spot scanning proton therapy minimizes neutron dose in the setting of radiation therapy administered during pregnancy

Effect of Scanning Beam for Superficial Dose in Proton Therapy

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