The lyophilized aqueous leaf extract of Moringa oleifera blunts streptozocin-induced diabetes in rats through upregulation of GLUT 4 signaling pathway and anti-oxidant effect

Adedapo, Adeolu Alex; Ogunmiluyi, Iyanuoluwa Omolola; Falayi, Olufunke Olubunmi; Ogunpolu, Blessing Seun; Oyagbemi, Ademola Adetokunbo; Orishadipe, A. T.; Omóbòwálé, Temidayo Olutayo; Yakubu, Momoh Audu; Oguntibeju, Oluwafemi Omoniyi

doi:10.1016/j.sciaf.2020.e00619

Cited by 3 publications

(3 citation statements)

References 32 publications

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“…In an experiment, aqueous lyophilised M. oleifera extract was compared to the standard drug Pioglitazone in STZ‐induced diabetic rats. Up‐regulation of GLUT4 was recorded in M. oleifera treated groups which reversed insulin resistance, the same as the standard drug Pioglitazone does (Adedapo et al, 2020). This evidence suggested the usage of M. oleifera as a supplement for the management of obesity and hyperglycaemia in MetS subjects.…”

Section: Effect On Key Mets‐associated Enzymes and Possible Mechanismsmentioning

confidence: 82%

Moringa oleifera Lam. as a potential plant for alleviation of the metabolic syndrome—A narrative review based on in vivo and clinical studies

Adarthaiya,

Sehgal

2023

Phytotherapy Research

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The metabolic syndrome (MetS) refers to the co‐occurrence of risk factors, including hyperglycaemia, increased body weight, hypertension and dyslipidemia, which eventually lead to diabetes and cardiovascular disease, a common health problem worldwide. Recently, there has been an increasing interest in the use of plant‐based products for the management of MetS, because of their less detrimental and more beneficial effects. Moringa oleifera (Moringaceae), commonly known as drumstick, is cultivated worldwide for its nutritional and medicinal properties. This review focuses on the in vivo and human studies concerning the potential of M. oleifera in the alleviation of MetS and its comorbidities. The search for relevant articles was carried out in PubMed and Google Scholar databases. Randomised controlled and clinical trials from the PubMed database were included in this review. The results suggested that the administration of M. oleifera, in vivo, shows clear signs of improvement in MetS indices. Despite fewer human studies, the existing data documented convincing results that uphold the potential of M. oleifera against MetS. Therefore, future research discussing the probable mechanism of action is much needed which could further assure the usage of M. oleifera in the treatment regimen of MetS.

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Section: Effect On Key Mets‐associated Enzymes and Possible Mechanismsmentioning

confidence: 82%

Moringa oleifera Lam. as a potential plant for alleviation of the metabolic syndrome—A narrative review based on in vivo and clinical studies

Adarthaiya,

Sehgal

2023

Phytotherapy Research

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“…From the pancreas and liver histologies, varied levels of inflammatory cell infiltration were observed, along with congestion and necrotic lesions. These tissue lesions were mild in Moringa -treated groups [ 95 ]. Furthermore, M. oleifera extract caused upregulation of glucose transporter 4 (GLUT 4), which is relevant in reversing insulin resistance in a similar way to pioglitazone, a standard antidiabetic agent [ 95 ].…”

Section: Bioactive Components Of M Oleifera and Th...mentioning

confidence: 99%

“…These tissue lesions were mild in Moringa -treated groups [ 95 ]. Furthermore, M. oleifera extract caused upregulation of glucose transporter 4 (GLUT 4), which is relevant in reversing insulin resistance in a similar way to pioglitazone, a standard antidiabetic agent [ 95 ]. GLUT 4 was downregulated in the untreated diabetic group compared to Moringa -treated groups, in which it was well expressed.…”

Section: Bioactive Components Of M Oleifera and Th...mentioning

confidence: 99%

Bioactive Compounds in Moringa oleifera: Mechanisms of Action, Focus on Their Anti-Inflammatory Properties

Chiș,

Noubissi,

Pop

et al. 2023

Plants

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Moringa oleifera (M. oleifera) is a tropical tree native to Pakistan, India, Bangladesh, and Afghanistan; it is cultivated for its nutritious leaves, pods, and seeds. This scientific study was conducted to outline the anti-inflammatory properties and mechanisms of action of bioactive compounds from M. oleifera. The existing research has found that the plant is used in traditional medicine due to its bioactive compounds, including phytochemicals: flavonoids and polyphenols. The compounds are thought to exert their anti-inflammatory effects due to: (1) inhibition of pro-inflammatory enzymes: quercetin and kaempferol inhibit the pro-inflammatory enzymes (cyclooxygenase and lipoxygenase); (2) regulation of cytokine production: isothiocyanates modulate signaling pathways involved in inflammation, such as the nuclear factor-kappa B (NF-kappa B) pathway; isothiocyanates inhibit the production of pro-inflammatory cytokines such as TNF-α (tumor necrosis factor α) and IL-1β (interleukin-1β); and (3) antioxidant activity: M. oleifera contains flavonoids, polyphenols, known to reduce oxidative stress and inflammation. The review includes M. oleifera’s effects on cardiovascular protection, anti-hypertensive activities, type 2 diabetes, inflammatory bowel disease, and non-alcoholic fatty liver disease (NAFLD). This research could prove valuable for exploring the pharmacological potential of M. oleifera and contributing to the prospects of developing effective medicines for the benefit of human health.

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The Potential of Moringa oleifera to Ameliorate HAART-Induced Pathophysiological Complications

Ndlovu

Ghazi

Chuturgoon

2022

Cells

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Highly active antiretroviral therapy (HAART) comprises a combination of two or three antiretroviral (ARV) drugs that are administered together in a single tablet. These drugs target different steps within the human immunodeficiency virus (HIV) life cycle, providing either a synergistic or additive antiviral effect; this enhances the efficiency in which viral replication is suppressed. HIV cannot be completely eliminated, making HAART a lifetime treatment. With long-term HAART usage, an increasing number of patients experience a broadening array of complications, and this significantly affects their quality of life, despite cautious use. The mechanism through which ARV drugs induce toxicity is associated with metabolic complications such as mitochondrial dysfunction, oxidative stress, and inflammation. To address this, it is necessary to improve ARV drug formulation without compromising its efficacy; alternatively, safe supplementary medicine may be a suitable solution. The medicinal plant Moringa Oleifera (MO) is considered one of the most important sources of novel nutritionally and pharmacologically active compounds that have been shown to prevent and treat various diseases. MO leaves are rich in polyphenols, vitamins, minerals, and tannins; studies have confirmed the therapeutic properties of MO. MO leaves provide powerful antioxidants, scavenge free radicals, promote carbohydrate metabolism, and repair DNA. MO also induces anti-inflammatory, hepatoprotective, anti-proliferative, and anti-mutagenic effects. Therefore, MO can be a source of affordable and safe supplement therapy for HAART-induced toxicity. This review highlights the potential of MO leaves to protect against HAART-induced toxicity in HIV patients.

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The lyophilized aqueous leaf extract of Moringa oleifera blunts streptozocin-induced diabetes in rats through upregulation of GLUT 4 signaling pathway and anti-oxidant effect

Cited by 3 publications

References 32 publications

Moringa oleifera Lam. as a potential plant for alleviation of the metabolic syndrome—A narrative review based on in vivo and clinical studies

Moringa oleifera Lam. as a potential plant for alleviation of the metabolic syndrome—A narrative review based on in vivo and clinical studies

Bioactive Compounds in Moringa oleifera: Mechanisms of Action, Focus on Their Anti-Inflammatory Properties

The Potential of Moringa oleifera to Ameliorate HAART-Induced Pathophysiological Complications

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