The Potential of Moringa oleifera to Ameliorate HAART-Induced Pathophysiological Complications

Ndlovu, Siqiniseko S.; Ghazi, Terisha; Chuturgoon, Anil A.

doi:10.3390/cells11192981

Cited by 5 publications

(1 citation statement)

References 151 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, oxidative stress leads to NRF2 dissociation from KEAP1, enabling NRF2 accumulation and phosphorylation in the cytoplasm. Phosphorylated NRF2 then translocates to the nucleus where it dimerizes with small Maf proteins and recognizes ARE sequences, promoting the transcription of antioxidant genes, such as HO-1 and SOD [37]. One study revealed that extraordinary intensities of oxidative stress led to NRF2 downregulation [38].…”

Section: Discussionmentioning

confidence: 99%

Integrating Network Pharmacology and Metabolomics to Explore the Potential Mechanism of Pinolenic Acid against Atherosclerosis

Cao,

Zhang,

Yang

et al. 2024

Journal of Food Biochemistry

View full text Add to dashboard Cite

Atherosclerosis (AS) is a global disease that causes a heavy economic burden and can significantly impact human health. Pinolenic acid (PLA) has antioxidant, anti-inflammatory, and lipid-lowering effects. However, it is unclear whether PLA holds a therapeutic promise for AS treatment or prevention. This study aims to investigate whether PLA can effectively treat AS and elucidate its therapeutic mechanism. To this end, potential PLA targets in AS treatment were identified by using network pharmacology. Additionally, an in vitro AS cell model was established by H2O2-induced damaging of human coronary artery endothelial cells (HCAECs). Subsequently, endothelial cell function was evaluated by evaluating cell proliferation, oxidative markers, reactive oxygen species (ROS), and nitric oxide (NO) levels. Cellular metabolomics was further employed to assess differential intracellular metabolites following H2O2 injury. In total, 87 overlapping target genes for PLA and AS were detected. PPI network analysis identified 38 hub genes closely associated with oxidative stress and fatty acid metabolism. Moreover, PLA improved cell survival and reduced oxidative stress injury by activating the NRF2/ARE signaling pathway in vitro. Cellular metabolomics confirmed that PLA might help maintain redox homeostasis and reduce endothelial cell injury by upregulating fatty acid β-oxidation. Taken together, our findings suggest that PLA prevents H2O2-induced HCAEC injury by maintaining redox homeostasis and may, therefore, represent a therapeutic potential for AS.

show abstract

Section: Discussionmentioning

confidence: 99%

Integrating Network Pharmacology and Metabolomics to Explore the Potential Mechanism of Pinolenic Acid against Atherosclerosis

Cao,

Zhang,

Yang

et al. 2024

Journal of Food Biochemistry

View full text Add to dashboard Cite

show abstract

Environmental, industrial, and health benefits of Moringa oleifera

Mahaveerchand,

Abdul Salam

2024

Phytochem Rev

View full text Add to dashboard Cite

The rise of air, water, and soil pollution poses a significant threat to global health, leading to widespread disease and premature mortality. Soil health is vital, ensuring the production of safe food, but it is compromised by pollutants such as heavy metals, pesticides, plastics, and excessive fertilization, resulting in the depletion of beneficial microorganisms and subsequently groundwater contamination. Water bodies are polluted due to contamination from industrial effluents, domestic wastewater, agricultural runoff, and oil spillage, further intensifying environmental pollution. On the other hand, atmospheric pollution, characterized by high emissions of gases, volatile compounds, greenhouse gases, not only impacts the climate but also poses serious risks to human health, leading to respiratory diseases, cardiovascular issues, and increased cancer risks. Thus, the strategic utilization of traditional plants emerges as a potent tool for environmental restoration and improving human health. The plants possess natural filtering capabilities, absorbing pollutants from air, soil, and water, thus mitigating their adverse effects. Through phytoremediation, plants can be actively used to extract and remove contaminants, contributing to detoxification and improving water and soil quality. Additionally, plants offer various health benefits. Moringa oleifera or the drumstick plant belonging to the Moringaceae family is one such indigenous plant with wide applications, that can be grown in extreme arid conditions. Since ancient times, this plant has been used for treating skin infections, anaemia, and blood impurities. This plant thrives in diverse climates addressing over 300 different aliments. Rich in phytochemicals and bioactive compounds, M. oleifera serve as a superfood, offering high nutritional values and exhibiting potential for drug development with fewer side effects. Extensive research has elucidated the diverse properties and applications of M. oleifera, however, in-depth research is needed to identify bioactive molecules, phytochemicals, and protein compounds involved, which will aid in understanding of the mechanisms of action of the plant's diverse functions. Although studies have reported several of individual M. oleifera attributes, there is no comprehensive study available addressing its diverse applications. This review covers the findings of past three decades and provides a detailed outline of M. oleifera plant and its various parts, its applications in environmental, industrial, food and health aspects documented to date.

show abstract

Moringa oleifera: Recent Insights for Its Biochemical and Medicinal Applications

Abdelazim,

Afifi,

Abu-Alghayth

et al. 2024

Journal of Food Biochemistry

View full text Add to dashboard Cite

Plants could be used for multiple medicinal purposes. Moringa oleifera (MO) is considered the most famous plant used for this purpose. The present review aimed to spot the light on the recent medicinal, biochemical, and nutritional applications of MO. The plant contains a huge number of nutrients such as fatty acids, amino acids, proteins, polysaccharides, minerals, and vitamins. It has been used to control glucose, lipids, proteins, minerals, vitamins, hormones, and antioxidants in many animals and human models. Its medicinal applications are also varied and wide; it could be used to control and manage lots of disorders. Extracts and isolated ingredients from the plant open the way for many researchers all over the world to study its biochemical and medicinal impact on many experimental and clinical models. The present review spots the light on the recent medicinal and biochemical significance of MO opening the discussion and demonstrating the strengths and weaknesses in the MO research area. Regardless of the contrary concept, we considered MO a promising plant that could be studied for its medicinal applications on both biochemical and molecular levels. We recommended further research on the molecular effects of MO in healthy and diseased models.

show abstract

The Potential of Moringa oleifera to Ameliorate HAART-Induced Pathophysiological Complications

Cited by 5 publications

References 151 publications

Integrating Network Pharmacology and Metabolomics to Explore the Potential Mechanism of Pinolenic Acid against Atherosclerosis

Integrating Network Pharmacology and Metabolomics to Explore the Potential Mechanism of Pinolenic Acid against Atherosclerosis

Environmental, industrial, and health benefits of Moringa oleifera

Moringa oleifera: Recent Insights for Its Biochemical and Medicinal Applications

Contact Info

Product

Resources

About