The Lung Tissue Microbiota of Mild and Moderate Chronic Obstructive Pulmonary Disease

Pragman, Alexa A.; Lyu, Tianmeng; Baller, Joshua A.; Gould, Trevor; Kelly, Rosemary F.; Reilly, Cavan; Isaacson, Richard E.; Wendt, Chris H.

doi:10.1093/ofid/ofx163.492

Cited by 20 publications

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“…Although the composition of the oral and lung microbiota are very similar, the lung likely harbors its own resident bacteria and may eliminate other common oral bacteria such as Prevotella species. [15][16][17][18][19] The composition of the healthy lung microbiota is consistent with an ecological model known as the neutral theory of community ecology. This theory, adapted to the lung, proposes that the lung microbiota is the result of random immigration of bacteria from the oral microbiota, random bacterial reproduction in the lung, and random elimination of lung bacteria.…”

Section: The Oral-lung Axis: a Physiologic Rationale For Associationsupporting

confidence: 67%

“…20 Interestingly, the healthy lung appears to be one of the few human sites to follow the neutral theory, supporting the interconnected microbial niche of the mouth and lungs. 1,[15][16][17][18][19] With this evidence, it is now generally accepted that the composition of the healthy lung microbiota is heavily influenced by repeated microaspiration of oropharyngeal contents.…”

Section: The Oral-lung Axis: a Physiologic Rationale For Associationmentioning

confidence: 99%

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The Oral-Lung Axis: The Impact of Oral Health on Lung Health

et al. 2020

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Poor oral health has long been recognized as a clinical risk factor for developing lung infections. Recent data using culture-independent techniques assessing the microbiome in healthy subjects have demonstrated that chronic microaspiration establishes a very similar microbial community between the mouth and lung, suggesting these 2 anatomic regions are closely intertwined. Dental disease is driven and aided by a dysbiosis in the oral microbiome, and evidence is mounting that implicates the microbiome in a variety of lung diseases including asthma, COPD, pulmonary fibrosis, and pneumonia. This review describes common dental conditions and potential mechanisms by which poor oral health may contribute to lung disease. We also review the current literature drawing associations between poor oral health and lung disease.

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Section: The Oral-lung Axis: a Physiologic Rationale For Associationsupporting

confidence: 67%

Section: The Oral-lung Axis: a Physiologic Rationale For Associationmentioning

confidence: 99%

The Oral-Lung Axis: The Impact of Oral Health on Lung Health

et al. 2020

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“…was, again, more present in the healthy group [74]. This scenario is also complicated by the fact that lung microbiome differs with the severity of the disease [75][76][77]. A similar situation has been also described for cystic fibrosis [72].…”

Section: Lung Microbiota Non-oncology Lung Diseases and Cancermentioning

confidence: 54%

The lung microbiota: role in maintaining pulmonary immune homeostasis and its implications in cancer development and therapy

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et al. 2020

Cell. Mol. Life Sci.

117

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Like other body districts, lungs present a complex bacteria community. An emerging function of lung microbiota is to promote and maintain a state of immune tolerance, to prevent uncontrolled and not desirable inflammatory response caused by inhalation of harmless environmental stimuli. This effect is mediated by a continuous dialog between commensal bacteria and immune cells resident in lungs, which express a repertoire of sensors able to detect microorganisms. The same receptors are also involved in the recognition of pathogens and in mounting a proper immune response. Due to its important role in preserving lung homeostasis, the lung microbiota can be also considered a mirror of lung health status. Indeed, several studies indicate that lung bacterial composition drastically changes during the occurrence of pulmonary pathologies, such as lung cancer, and the available data suggest that the modifications of lung microbiota can be part of the etiology of tumors in lungs and can influence their progression and response to therapy. These results provide the scientific rationale to analyze lung microbiota composition as biomarker for lung cancer and to consider lung microbiota a new potential target for therapeutic intervention to reprogram the antitumor immune microenvironment. In the present review, we discussed about the role of lung microbiota in lung physiology and summarized the most relevant data about the relationship between lung microbiota and cancer.

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“…One reason for this might be that composition varies between samples depending upon the type of treatment received, disease severity and inflammation. Previous studies have shown association between very severe COPD and eosinophilic phenotypes with dominance of Firmicutes, while Proteobacteria are predominant in moderate COPD and the bacterial related phenotype [9,28] . The COPD cohort analysed here was mainly of moderate-tosevere severity with high neutrophil counts.…”

Section: Discussionmentioning

confidence: 90%

The sputum microbiome is distinct between COPD and health, independent of smoking history

et al. 2020

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Background: Airway bacterial dysbiosis is a feature of chronic obstructive pulmonary disease (COPD). However, there is limited comparative data of the lung microbiome between healthy smokers, non-smokers and COPD. Methods: We compared the 16S rRNA gene-based sputum microbiome generated from pair-ended Illumina sequencing of 124 healthy subjects (28 smokers and 96 non-smokers with normal lung function), with single stable samples from 218 COPD subjects collected from three UK clinical centres as part of the COPDMAP consortium. Results: In healthy subjects Firmicutes, Bacteroidetes and Actinobacteria were the major phyla constituting 88% of the total reads, and Streptococcus, Veillonella, Prevotella, Actinomyces and Rothia were the dominant genera. Haemophilus formed only 3% of the healthy microbiome. In contrast, Proteobacteria was the most dominant phylum accounting for 50% of the microbiome in COPD subjects, with Haemophilus and Moraxella at genus level contributing 25 and 3% respectively. There were no differences in the microbiome profile within healthy and COPD subgroups when stratified based on smoking history. Principal coordinate analysis on operational taxonomic units showed two distinct clusters, representative of healthy and COPD subjects (PERMANOVA, p = 0•001). Conclusion: The healthy and COPD sputum microbiomes are distinct and independent of smoking history. Our results underline the important role for Gammaproteobacteria in COPD.

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The Lung Tissue Microbiota of Mild and Moderate Chronic Obstructive Pulmonary Disease

Cited by 20 publications

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The Oral-Lung Axis: The Impact of Oral Health on Lung Health

The Oral-Lung Axis: The Impact of Oral Health on Lung Health

The lung microbiota: role in maintaining pulmonary immune homeostasis and its implications in cancer development and therapy

The sputum microbiome is distinct between COPD and health, independent of smoking history

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