The lung microbiota: role in maintaining pulmonary immune homeostasis and its implications in cancer development and therapy

Sommariva, Michele; Noci, Valentino Le; Bianchi, Francesca; Camelliti, Simone; Balsari, Andrea; Tagliabue, Elda; Sfondrini, Lucia

doi:10.1007/s00018-020-03452-8

Cited by 122 publications

(119 citation statements)

References 95 publications

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“…Activation of lung immune cells that initiates innate and adaptive immunity requires microbe exposure [58] . The function of one of the vital effector and regulator cells of the lung, γδ T cells, depends on pathogen invasion [47] , [59] .…”

Section: Lung Microbiome and Covid-19 Diseasementioning

confidence: 99%

Lung microbiome and coronavirus disease 2019 (COVID-19): Possible link and implications

Khatiwada

Subedi

2020

Human Microbiome Journal

106

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Coronavirus disease 2019 (COVID-19) is a rapidly emerging disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease begins as an infection of lungs, which is self-limiting in the majority of infections; however, some develop severe respiratory distress and organ failures. Lung microbiome, though neglected previously have received interest recently because of its association with several respiratory diseases and immunity. Lung microbiome can modify the risk and consequences of COVID-19 disease by activating an innate and adaptive immune response. In this review, we examine the current evidence on COVID-19 disease and lung microbiome, and how lung microbiome can affect SARS-CoV-2 infection and the outcomes of this disease. To date there is no direct evidence from human or animal studies on the role of lung microbiome in modifying COVID-19 disease; however, related studies support that microbiome can play an essential role in developing immunity against viral infections. Future studies need to be undertaken to find the relationship between lung microbiome and COVID-19 disease.

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Section: Lung Microbiome and Covid-19 Diseasementioning

confidence: 99%

Lung microbiome and coronavirus disease 2019 (COVID-19): Possible link and implications

Khatiwada

Subedi

2020

Human Microbiome Journal

106

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“…The escape of cancer cells from immune surveillance is associated with their tolerance and enhanced proliferation (Sommariva et at., 2020). The CD4+ CD25+ forkhead box protein‐3 (FOXP3) regulatory T cells (Treg) contribute to immune tolerance of cancer cells by production of TGF‐β and other cytokines to ensure the growth of cancer cells and their escape from cancer‐specific cytotoxic CD8+ T cells (B.‐Q.…”

Section: Curcumin and Lung Cancermentioning

confidence: 99%

Versatile role of curcumin and its derivatives in lung cancer therapy

Ashrafizadeh

Najafi

Makvandi

et al. 2020

Journal Cellular Physiology

101

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Lung cancer is a main cause of death all over the world with a high incidence rate. Metastasis into neighboring and distant tissues as well as resistance of cancer cells to chemotherapy demand novel strategies in lung cancer therapy. Curcumin is a naturally occurring nutraceutical compound derived from Curcuma longa (turmeric) that has great pharmacological effects, such as anti‐inflammatory, neuroprotective, and antidiabetic. The excellent antitumor activity of curcumin has led to its extensive application in the treatment of various cancers. In the present review, we describe the antitumor activity of curcumin against lung cancer. Curcumin affects different molecular pathways such as vascular endothelial growth factors, nuclear factor‐κB (NF‐κB), mammalian target of rapamycin, PI3/Akt, microRNAs, and long noncoding RNAs in treatment of lung cancer. Curcumin also can induce autophagy, apoptosis, and cell cycle arrest to reduce the viability and proliferation of lung cancer cells. Notably, curcumin supplementation sensitizes cancer cells to chemotherapy and enhances chemotherapy‐mediated apoptosis. Curcumin can elevate the efficacy of radiotherapy in lung cancer therapy by targeting various signaling pathways, such as epidermal growth factor receptor and NF‐κB. Curcumin‐loaded nanocarriers enhance the bioavailability, cellular uptake, and antitumor activity of curcumin. The aforementioned effects are comprehensively discussed in the current review to further direct studies for applying curcumin in lung cancer therapy.

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“…The incipient composition of the lung microbiota cannot be neglected because it is closely related to the onset of mucosal immunity (18), the development of immune tolerance in the lungs (19), and healthy breathing (15). Several reports have shown alterations in the stability and diversity of the respiratory tract microbiota in BPD.…”

Section: Airway Microbiota Dysbiosis In Bpdmentioning

confidence: 99%

Perspectives on Probiotics and Bronchopulmonary Dysplasia

Yang

Dong

2020

Front. Pediatr.

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Bronchopulmonary dysplasia (BPD) is a chronic respiratory disease of preterm infants, associated with high morbidity and hospitalization expenses. With the revolutionary advances in microbiological analysis technology, increasing evidence indicates that children with BPD are affected by lung microbiota dysbiosis, which may be related to the illness occurrence and progression. However, dysbiosis treatment in BPD patients has not been fully investigated. Probiotics are living microorganisms known to improve human health for their anti-inflammatory and anti-tumor effects, and particularly by balancing gut microbiota composition, which promotes gut-lung axis recovery. The aim of the present review is to examine current evidence of lung microbiota dysbiosis and explore potential applications of probiotics in BPD, which may provide new insights into treatment strategies of this disease.

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The lung microbiota: role in maintaining pulmonary immune homeostasis and its implications in cancer development and therapy

Cited by 122 publications

References 95 publications

Lung microbiome and coronavirus disease 2019 (COVID-19): Possible link and implications

Lung microbiome and coronavirus disease 2019 (COVID-19): Possible link and implications

Versatile role of curcumin and its derivatives in lung cancer therapy

Perspectives on Probiotics and Bronchopulmonary Dysplasia

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