The Lund concept: is this logical?

Abstract

SummaryThe optimal therapy of sustained increase in intracranial pressure (ICP) is still controversial. The "Lund concept" is based on the physiological volume regulation of the intracranial compartments. In addition to its other functions the blood-brain barrier (BBB) is the most important regulator of brain volume. Water exchange across the intact BBB is counteracted by the low permeability to crystalloids (mainly Na + and Cl -) combined with the high osmotic pressure (5,700 mm Hg) on both sides of the BBB. If the BBB is disrupted transcapillary water transport will be determined by the differences in hydrostatic and colloid osmotic pressure between the intra-and extracapillary compartments. Under pathological conditions pressure autoregulation of cerebral blood flow is often impaired and intracapillary hydrostatic pressure will depend on variations in systemic blood pressure.

Decreased Frontal Lobe Gray Matter Perfusion in Cognitively Impaired Patients with Secondary-Progressive Multiple Sclerosis Detected by the Bookend Technique

“…7,9 These venous changes are well described in MS and would be expected to be most severe in advanced disease states such as SPMS. Approximately 70% of CBV is accounted for by venous capacitance, 30 and its quantitative equivalent, qCBV, should exhibit a similar relationship. By virtue of this strong association, qCBV should be greatly impacted by pathologies that decrease venous capacitance, such as those discussed here.…”