The lumbar intervertebral disc: From embryonic development to degeneration

Colombier, Pauline; Clouet, Johann; Hamel, Olivier; Lescaudron, Laurent; Guicheux, Jérôme

doi:10.1016/j.jbspin.2013.07.012

Cited by 135 publications

(126 citation statements)

References 38 publications

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“…These include reduced water retention in the NP [5,7,8], increased percent of type I collagen within the NP and inner AF [9], degradation of collagen and extracellular matrix (ECM) materials [10], and upregulation of systems of degradation such as apoptosis, matrix metalloproteinase (MMP) expression, and inflammatory pathways [11].…”

Section: Pathology Of Ldhmentioning

confidence: 99%

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Lumbar Disc Herniation

Amin

Andrade

Neuman³

2017

Curr Rev Musculoskelet Med

227

202

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Purpose of Review Substantial advancements have been made in the cause, diagnosis, imaging, and treatment options available for patients with lumbar disc herniation (LDH). We examined the current evidence and highlight the concepts on the frontline of discovery in LDH. Recent Findings There are a myriad of novel etiologies of LDH detailed in recent literature including inflammatory factors and infectious microbes. In the clinical setting, recent data focuses on improvements in computer tomography as a diagnostic tool and non-traditional injection options including tumor necrosis alpha inhibitors and platelet-rich plasma. Operative treatment outcomes have focused on minimally invasive endoscopic approaches and demonstrated robust 5-year post-operative outcomes. Summary Advances in the molecular etiology of LDH will continue to drive novel treatment options. The role of endoscopic treatment for LDH will continue to evolve. Further research into10-year outcomes will be necessary as this surgical approach continues to gain widespread popularity.

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Section: Pathology Of Ldhmentioning

confidence: 99%

“…Dehydration is known to contribute to the pathogenesis of degenerative disc disease [7,8]. Although a specific genetic polymorphism has not been associated with LDH, aquaporins have been implicated.…”

Section: Dehydrationmentioning

confidence: 99%

Lumbar Disc Herniation

Amin

Andrade

Neuman³

2017

Curr Rev Musculoskelet Med

227

202

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“…The inner AF, which is also known as the transition zone, contains poorly organised extracellular matrix composed of type II collagen, proteoglycans, and water. In contrast, the outer AF is highly organised and is rich in type I collagen, with undetectable levels of type II collagen and proteoglycans, and higher resistance to tension [19].…”

Section: Annulus Fibrosusmentioning

confidence: 98%

“…The proteoglycan to collagen ratio is approximately 27:1 [19]. These large quantities of aggrecan located along chains of hyaluronan carry a fixed negative charge and generate an osmotic swelling pressure within the irregular meshwork of collagen type II fibrils [72].…”

Section: Nucleus Pulposusmentioning

confidence: 99%

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The biology behind the human intervertebral disc and its endplates

et al. 2015

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PHLDA2 overexpression facilitates senescence and apoptosis via the mitochondrial route in human nucleus pulposus cells by regulating Wnt/β‐catenin signalling pathway

Chang,

Cao,

et al. 2024

IUBMB Life

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Low back pain is a common clinical symptom of intervertebral disc degeneration (IVDD), which seriously affects the quality of life of the patients. The abnormal apoptosis and senescence of nucleus pulposus cells (NPCs) play important roles in the pathogenesis of IVDD. PHLDA2 is an imprinted gene related to cell apoptosis and tumour progression. However, its role in NPC degeneration is not yet clear. Therefore, this study was set to explore the effects of PHLDA2 on NPC senescence and apoptosis and the underlying mechanisms. The expression of PHLDA2 was examined in human nucleus pulposus (NP) tissues and NPCs. Immunohistochemical staining, magnetic resonance imaging imaging and western blot were performed to evaluate the phenotypes of intervertebral discs. Senescence and apoptosis of NPCs were assessed by SA‐β‐galactosidase, flow cytometry and western blot. Mitochondrial function was investigated by JC‐1 staining and transmission electron microscopy. It was found that the expression level of PHLDA2 was abnormally elevated in degenerated human NP tissues and NPCs. Furthermore, knockdown of PHLDA2 can significantly inhibit senescence and apoptosis of NPCs, whereas overexpression of PHLDA2 can reverse senescence and apoptosis of NPCs in vitro. In vivo experiment further confirmed that PHLDA2 knockdown could alleviate IVDD in rats. Knockdown of PHLDA2 could also reverse senescence and apoptosis in IL‐1β‐treated NPCs. JC‐1 staining indicated PHLDA2's knockdown impaired disruption of the mitochondrial membrane potential and also ameliorated superstructural destruction of NPCs as showed by transmission electron microscopy. Finally, we found the PHLDA2 knockdown promoted Collagen‐II expression and suppressed MMP3 expression in NPCs by repressing wnt/β‐catenin pathway. In conclusion, the results of the present study showed that PHLDA2 promotes IL‐1β‐induced apoptosis and senescence of NP cells via mitochondrial route by activating the Wnt/β‐catenin pathway, and suggested that therapy targeting PHLDA2 may provide valuable insights into possible IVDD therapies.

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The lumbar intervertebral disc: From embryonic development to degeneration

Cited by 135 publications

References 38 publications

Lumbar Disc Herniation

Lumbar Disc Herniation

The biology behind the human intervertebral disc and its endplates

PHLDA2 overexpression facilitates senescence and apoptosis via the mitochondrial route in human nucleus pulposus cells by regulating Wnt/β‐catenin signalling pathway

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