The<b><i> IL20</i></b> Genetic Polymorphism Is Associated with Altered Clinical Outcome in Septic Shock

Abstract

Background: The IL10 family of genes includes crucial immune regulators.We tested the hypothesis that single nucleotide polymorphisms (SNPs) in IL10, IL19, IL20, and IL24 of the IL10 family gene cluster alter the clinical outcome of septic shock. Methods: Patients with septic shock (n = 1,193) were genotyped for 13 tag SNPs of IL10, IL19, IL20, and IL24. IL20 gene expression was measured in genotyped lymphoblastoid cells in vitro. Cardiac surgical ICU patients (n = 981) were genotyped for IL20 rs2981573 A/G. The primary outcome variable was 28-day mortality. Results: Patients with the G allele of IL20 rs2981573 had a significantly increased hazard of death over the 28-day period compared to patients with the A allele in the septic shock cohort (adjusted hazard ratio 1.27; 95% confidence interval 1.10-1.47; p = 8.0 × 10^-4). Patients with the GG genotype had more organ dysfunction (p < 0.05). The GG genotype was associated with increased IL20 gene expression in stimulated lymphoblastoid cells in vitro (p < 0.05). The cardiac surgical ICU patients with the GG genotype had an increased length of ICU stay (p = 0.032). Conclusions: The GG genotype of IL20 rs2981573 SNP was associated with increased IL20 gene expression and increased adverse outcomes in patients with septic shock and following cardiac surgery.

Who is WHO?

“…In another study dealing with a clinical aspect of sepsis, Jon Olinder and co-workers [4] found that hepcidin, a peptide hormone controlling plasma levels of iron, can be used as a diagnostic tool in patients suffering from severe infectious diseases. These two contributions are in line with other recently published articles in Journal of Innate Immunity demonstrating that deciphering molecular mechanisms causing severe complications in infectious diseases can lead to novel concepts in diagnosis and treatment [5][6][7][8][9]. The immunomodulation in sepsis and septic shock shares similarities with other diseases, such as chronic obstructive pulmonary disease and cystic fibrosis [10][11][12].…”

Significance of body temperature in elderly patients with sepsis

“…Our primary analysis used Cox regression to test for hazard of death over 90 days by the vital signs in the elderly and non-elderly groups. We selected this approach to adjust for potential baseline imbalances, including age (per year), sex, chronic steroid use, and APACHE II score (Additional file 1: Table S2, correlation analysis) based on previous reports [18,23]. Significant discovery results were tested for replication and generalizability in patients of the same ancestry in validation cohort 1 and patients of different ancestry in validation cohort 2.…”

IL-20 Cytokines Are Involved in Epithelial Lesions Associated with Virus-Induced COPD Exacerbation in Mice

“…Additional experiments are required in order to analyze the epithelial permeability in a model of air–liquid interface after viral infection and the role of IL-20 cytokines. Moreover, it has been shown that some polymorphism in IL-19 and IL-20 genes could worsen the outcome of chronic hepatitis B infection [ 14 ] and septic shock [ 40 ]. IL-20 cytokines may be a common link between these diseases.…”