The Low Level of Response to Alcohol-Based Heavy Drinking Prevention Program: One-Year Follow-Up

Schuckit, Marc A.; Smith, Tom L.; Clausen, Peyton; Fromme, Kim; Skidmore, Jessica R.; Shafir, Alexandra; Kalmijn, Jelger

doi:10.15288/jsad.2016.77.25

Cited by 38 publications

(51 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Their predictive validities regarding future heavy drinking and alcohol problems across different populations and sexes in studies conducted in the United States, United Kingdom, and Switzerland are also consistent . These studies cumulatively indicate that an individual's LR, as measured by the SRE, could serve as an additional risk marker for the development of problem drinking, and can be a useful tool in efforts to personalize prevention and treatment …”

Section: Introductionmentioning

confidence: 56%

“…As additional samples with SRE data, specifically SRE‐T, become available, individual loci and polygenic risk scores from such GWAS might explain even greater variance in LR. It will set the stage for future interventions that might aim to interrupt progression to AD . This boost in power necessitates further collection of SRE data.…”

Section: Discussionmentioning

confidence: 99%

“…Multiple putative pathways, including overly positive expectations of the effects of alcohol, heavier peer drinking, and using alcohol to cope with stress, have also been found to contribute to the heightened risk for AD in those with low LR. Interestingly, recent research suggests college‐based prevention programs that target LR are effective in individuals with low, but not high, LR . Thus, even though low LR is a marker for predisposition to AD, largely via heavy consumption, individual differences in LR are also associated with unique sources of variance.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Genome‐wide association studies of the self‐rating of effects of ethanol (SRE)

et al. 2019

View full text Add to dashboard Cite

The level of response (LR) to alcohol as measured with the Self-Report of the Effects of Alcohol Retrospective Questionnaire (SRE) evaluates the number of standard drinks usually required for up to four effects. The need for a higher number of drinks for effects is genetically influenced and predicts higher risks for heavy drinking and alcohol problems. We conducted genome-wide association study (GWAS) in the African-American (COGA-AA, N = 1527 from 309 families) and European-American (COGA-EA, N = 4723 from 956 families) subsamples of the Collaborative Studies on the Genetics of Alcoholism (COGA) for two SRE scores: SRE-T (average of first five times of drinking, the period of heaviest drinking, and the most recent 3 months of consumption) and SRE-5 (the first five times of drinking). We then meta-analyzed the two COGA subsamples (COGA-AA + EA). Both SRE-T and SRE-5 were modestly heritable (h 2 : 21%-31%) and genetically correlated with alcohol dependence (AD) and DSM-IV AD criterion count (r g : 0.35-0.76). Genome-wide significant associations

show abstract

Section: Introductionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Genome‐wide association studies of the self‐rating of effects of ethanol (SRE)

et al. 2019

View full text Add to dashboard Cite

show abstract

“…61,62,83 Each of these pathways has been shown to benefit from tailored personalized intervention. [83][84][85] Schuckit et al 83 These examples are specific to alcohol, but the idea of heterogeneous genetically influenced pathways is likely to be broadly applicable to psychiatric/substance use disorders. Heterogeneity in symptoms, course and etiology of disorders is recognized as a profound challenge in studying psychopathology.…”

Section: Understanding Mechanismmentioning

confidence: 99%

Post‐GWAS in Psychiatric Genetics: A Developmental Perspective on the “Other” Next Steps

Dick

Barr

Cho

et al. 2018

Genes Brain and Behavior

View full text Add to dashboard Cite

As psychiatric genetics enters an era where gene identification is finally yielding robust, replicable genetic associations and polygenic risk scores, it is important to consider next steps and delineate how that knowledge will be applied to ultimately ameliorate suffering associated with substance use and psychiatric disorders. Much of the post-genome-wide association study discussion has focused on the potential of genetic information to elucidate the underlying biology and use this information for the development of more effective pharmaceutical treatments. In this review we focus on additional areas of research that should follow gene identification. By taking genetic findings into longitudinal, developmental studies, we can map the pathways by which genetic risk manifests across development, elucidating the early behavioral manifestations of risk, and studying how various environments and interventions moderate that risk across developmental stages. The delineation of risk across development will advance our understanding of mechanism, sex differences and risk and resilience processes in different racial/ethnic groups. Here, we review how the extant twin study literature can be used to guide these efforts. Together, these new lines of research will enable us to develop more informed, tailored prevention and intervention efforts.

show abstract

“…Lower initial sensitivity to alcohol is a risk factor for higher alcohol consumption and subsequent problems. Improved understanding of factors that impact one's alcohol sensitivity may therefore be useful in understanding trajectories from early to problematic alcohol use, and can be used as a focus for prevention programs (Schuckit et al., ).…”

mentioning

confidence: 99%

Long‐Chain ω‐3 Levels Are Associated With Increased Alcohol Sensitivity in a Population‐Based Sample of Adolescents

Edwards

Heron

Hibbeln

et al. 2019

Alcoholism Clin & Exp Res

Self Cite

View full text Add to dashboard Cite

Background: The levels of the x-3 long-chain polyunsaturated fatty acids (x-3 LC-PUFAs), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been associated with alcohol sensitivity in vertebrate and invertebrate model systems, but prior studies have not examined this association in human samples despite evidence of associations between x-3 LC-PUFA levels and alcohol-related phenotypes. Both alcohol sensitivity and x-3 LC-PUFA levels are impacted by genetic factors, and these influences may contribute to observed associations between phenotypes. Given the potential for using EPA and DHA supplementation in adjuvant care for alcohol misuse and other outcomes, it is important to clarify how x-3 LC-PUFA levels relate to alcohol sensitivity.Methods: Analyses were conducted using data from the Avon Longitudinal Study of Parents and Children. Plasma x-3 LC-PUFA levels were measured at ages 15.5 and 17.5. Participants reported on their initial alcohol sensitivity using the early drinking Self-Rating of the Effects of Alcohol (SRE-5) scale, for which more drinks needed for effects indicates lower levels of response per drink, at ages 15.5, 16.5, and 17.5. Polygenic liability for alcohol consumption, alcohol problems, EPA levels, and DHA levels was derived using summary statistics from large, publicly available datasets. Linear regressions were used to examine the cross-sectional and longitudinal associations between x-3 LC-PUFA levels and SRE scores.Results: Age 15.5 x-3 LC-PUFA levels were negatively associated with contemporaneous SRE scores and with age 17.5 SRE scores. One modest association (p = 0.02) between polygenic liability and SRE scores was observed, between alcohol problems-based polygenic risk scores (PRS) and age 16.5 SRE scores. Tests of moderation by genetic liability were not warranted.Conclusions: Plasma x-3 LC-PUFA levels may be related to initial sensitivity to alcohol during adolescence. These data indicate that diet-related factors have the potential to impact humans' earliest responses to alcohol exposure.

show abstract

The Low Level of Response to Alcohol-Based Heavy Drinking Prevention Program: One-Year Follow-Up

Cited by 38 publications

References 38 publications

Genome‐wide association studies of the self‐rating of effects of ethanol (SRE)

Genome‐wide association studies of the self‐rating of effects of ethanol (SRE)

Post‐GWAS in Psychiatric Genetics: A Developmental Perspective on the “Other” Next Steps

Long‐Chain ω‐3 Levels Are Associated With Increased Alcohol Sensitivity in a Population‐Based Sample of Adolescents

Contact Info

Product

Resources

About