The low-dose atorvastatin and valsartan combination effectively protects the arterial wall from atherogenic diet-induced impairment in the guinea pig

Janić, Miodrag; Lunder, Mojca; Zupan, Janja; Černe, Darko; Marc, Janja; Drevenšek, Gorazd; Šabovič, Mišo

doi:10.1016/j.ejphar.2014.09.027

Cited by 7 publications

(5 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Low-dose rosuvastatin has been shown to cause fewer potential side-effects than high dose rosuvastatin (37,40). In addition, some beneficial pleiotropic effects of rosuvastatin such as antiinflammation and anti-oxidation are not strictly dose dependent (37). On the other hand, we did not found the association of the variability in lipids with the risks of intracerebral hemorrhage, subarachnoid hemorrhage, and newly incident diabetes mellitus.…”

Section: Discussioncontrasting

confidence: 61%

“…The risks of composite cardiovascular event, myocardial infarction, heart failure, ischemic stroke, cardiovascular death, and all-cause death were significantly lower in the rosuvastatin group than the placebo group. Statins have been shown to exert protective effects against cardio-and cerebro-vascular diseases (25, [36][37][38]. The results of the HOPE-3 (Heart Outcomes Prevention Evaluation) trial have revealed that low-dose rosuvastatin decreases cardiovascular diseases in participants with two or more healthful lifestyle factors (HR: 0.74 with 95% CI: 0.62-0.90) and in participants with fewer than two factors (HR: 0.79 with 95% CI: 0.61-1.01) (25).…”

Section: Discussionmentioning

confidence: 99%

“…Low-dose rosuvastatin administration may be an important cause of these results. Low-dose rosuvastatin has been shown to cause fewer potential side-effects than high dose rosuvastatin (37,40). In addition, some beneficial pleiotropic effects of rosuvastatin such as antiinflammation and anti-oxidation are not strictly dose dependent (37).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Attenuating the Variability of Lipids Is Beneficial for the Hypertension Management to Reduce the Cardiovascular Morbidity and Mortality in Older Adults

Dong

Liu

Zhao

et al. 2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Objective: To investigate the beneficial of attenuating the variability of lipids to the hypertension management in older adults.Methods: Between April 2008 and November 2010, 1,244 hypertensive patients aged ≥60 years were recruited and randomized into placebo and rosuvastatin groups. Outcomes and inter-visit plasma lipids variability were assessed.Results: Over an average follow-up of 83.5 months, the coefficients of variation (CVs) in total cholesterol (TCHO), triglycerides, high-density lipoprotein cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDL-c) were significantly lower in the rosuvastatin group than the placebo group (p < 0.05). The risks of composite cardiovascular event, myocardial infarction, coronary revascularization, heart failure, total stroke, ischemic stroke, cardiovascular death, and all-cause death were significantly lower in the rosuvastatin group than the placebo group (all p < 0.05). The differences in the risks were significantly diminished after the CVs for TCHO, triglycerides, HDL-c, and LDL-c were separately included as confounders. One-SD of CVs for TCHO, triglycerides, HDL-c, and LDL-c increment were significantly associated with the risks of composite cardiovascular event, myocardial infarction, heart failure, total stroke, ischemic stroke, cardiovascular death, and all-cause death, respectively (all p < 0.05).Conclusions: Rosuvastatin significantly attenuated the intra-visit variability in lipids and decreased the risk of cardiovascular mortality and morbidity. Controlling the variability of lipids is as important as antihypertensive treatment to reduce the cardiovascular morbidity and mortality in the management of older hypertensive patients.Clinical Trial Registration:ChiCTR.org.cn, ChiCTR-IOR-17013557.

show abstract

Section: Discussioncontrasting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Attenuating the Variability of Lipids Is Beneficial for the Hypertension Management to Reduce the Cardiovascular Morbidity and Mortality in Older Adults

Dong

Liu

Zhao

et al. 2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…The guinea pigs were shown to be one of the best models for evaluating atherosclerotic damage (Janić et al 2014). Similar to humans, these animals store most of their blood cholesterol in LDL form, possess similar enzymes associated with cholesterol synthesis and are highly sensitive to dietary lipid intake (Fernandez and Volek 2006).…”

Section: Discussionmentioning

confidence: 99%

Silver fir (Abies alba) trunk extract protects guinea pig arteries from impaired functional responses and morphology due to an atherogenic diet

et al. 2015

Self Cite

View full text Add to dashboard Cite

“…Besides that, statin therapy is associated with the prevention of acute coronary syndrome [7]. It has been demonstrated, that a low-dose combination of atorvastatin and valsartan, used for the treatment of high blood pressure, protected the thoracic aorta wall in guinea pigs from atherogenic diet-induced lesions as well as nanoparticle of hyaluronan-atorvastatin conjugate to increase the bioavailability [22,23].…”

Section: Introductionmentioning

confidence: 99%

Effect of cholesterol re-supplementation and atorvastatin on plaque composition in the thoracic aorta of New Zealand white rabbits

Bonaterra

Bender

Wilhelm

et al. 2020

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Background Effects of re-supplementation of a cholesterol-enriched diet (CEDrs) on size, cholesterol content and morphology of already existing plaques are not known to date. Methods A group of rabbits received standard chow (SC) for 6 weeks (“negative control”; for plasma lipid measurements only). Group I-IV received 2% CED (induction) for 6 weeks; thereafter, groups II-IV have been fed a SC (= cholesterol withdrawal) for 68 weeks. Afterwards, feeding of groups II-IV was continued as follows: Group II - 10 weeks SC, group III - 4 weeks 0.5% CED (~re-supplementation), afterwards 6 weeks SC (~withdrawal again); group IV - 4 weeks 0.5% CED (re-supplementation) + atorvastatin (2.5 mg/kg body weight/day), afterwards 6 weeks SC (~withdrawal again) + atorvastatin. Plasma lipids, but also plaque size, morphology and cholesterol contents of thoracic aortas were quantified. Results After CEDrs, plasma cholesterol levels were increased. However, after withdrawal of CEDrs, plasma cholesterol levels decreased, whereas the cholesterol content of the thoracic aorta was increased in comparison with the group without CEDrs. Plaque size remained unaffected. Atorvastatin application did not change plasma cholesterol level, cholesterol content of the thoracic aorta and plaque size in comparison with the group without drug treatment. However, atorvastatin treatment increased the density of macrophages (MΦ) compared with the group without treatment, with a significant correlation between densities of MΦ (Mac-1+) and apoptotic (TUNEL+; TP53+), antigen-presenting (HLA-DR+) or oxidatively stressed (SOD2+) cells. Conclusions In rabbits with already existing plaques, CEDrs affects plaque morphology and cellular composition, but not plaque size. Despite missing effects on plasma cholesterol levels, cholesterol content of the thoracic aorta and size of already existing atherosclerotic plaques, atorvastatin treatment transforms the already existing lesions to a more active form, which may accelerate the remodelling to a more stable plaque.

show abstract

The low-dose atorvastatin and valsartan combination effectively protects the arterial wall from atherogenic diet-induced impairment in the guinea pig

Cited by 7 publications

References 20 publications

Attenuating the Variability of Lipids Is Beneficial for the Hypertension Management to Reduce the Cardiovascular Morbidity and Mortality in Older Adults

Attenuating the Variability of Lipids Is Beneficial for the Hypertension Management to Reduce the Cardiovascular Morbidity and Mortality in Older Adults

Silver fir (Abies alba) trunk extract protects guinea pig arteries from impaired functional responses and morphology due to an atherogenic diet

Effect of cholesterol re-supplementation and atorvastatin on plaque composition in the thoracic aorta of New Zealand white rabbits

Contact Info

Product

Resources

About