Silver fir (Abies alba) trunk extract protects guinea pig arteries from impaired functional responses and morphology due to an atherogenic diet

Drevenšek, Gorazd; Lunder, Mojca; Benković, Eva Tavčar; Mikelj, Ana; Štrukelj, Borut; Kreft, Samo

doi:10.1016/j.phymed.2015.06.004

Cited by 14 publications

(8 citation statements)

References 25 publications

(29 reference statements)

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“…Higher in vitro antioxidant activity towards hydroxyl radicals, in comparison with few reference substances, such as resveratrol, Butylated hydroxytoluene, vitamin E, and epigallocatechin gallate, was shown for aqueous extracts of silver fir trunk [22]. Moreover, the same aqueous extracts, added to an atherogenic diet of guinea pigs, improved the relaxation response and prevented the development of atherosclerotic plaques in aorta, thus confirming an important bioactivity.…”

Section: Introductionmentioning

confidence: 70%

Affordable Production of Antioxidant Aqueous Solutions by Hydrodynamic Cavitation Processing of Silver Fir (<em>Abies Alba</em> Mill.) Needles

Albanese

Bonetti²,

D’Acqui³

et al. 2018

Preprint

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Extracts from parts of coniferous trees have received increased interest due to their valuable bioactive compounds and properties, useful for plenty of experimental and consolidated applications, in fields comprising nutraceutics, cosmetics, pharmacology, food preservation, and stimulation of plant growth. However, the variability of the bioactive properties, the complexity of the extraction methods, and the use of potentially harmful synthetic chemicals, still represent an obstacle to the spreading of such valuable natural compounds. Hydrodynamic cavitation is emerging as a promising innovative technique for the extraction of precious food components and by-products from waste raw material of the agro-food production chain, which can improve processing efficiency, reduce resource consumption, and produce healthy, high-quality products. In this study, a process based on controlled hydrodynamic cavitation was applied for the first time to the production of aqueous solutions of silver fir (Abies Alba Mill.) needles with enhanced antioxidant activity. The observed levels of the in vitro antioxidant activity, comparable or higher than those found for reference substances, pure extracts, and other water extracts and beverages, highlight the very good potential of the HC process for the creation of solvent-free, aqueous solutions endowed with bioactive compounds extracted from silver fir needles.

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Section: Introductionmentioning

confidence: 70%

Affordable Production of Antioxidant Aqueous Solutions by Hydrodynamic Cavitation Processing of Silver Fir (<em>Abies Alba</em> Mill.) Needles

Albanese

Bonetti²,

D’Acqui³

et al. 2018

Preprint

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show abstract

“…The extraction procedure and detailed extract characterization, including chromatographic profiling, are described in our previous publications ( 1 , 2 ).…”

Section: Methodsmentioning

confidence: 99%

“…In our previous studies, we observed that SFTE exhibited strong antioxidative properties in vitro in 2,2-diphenyl-1-picrylhydrazyl (DPPH) test and ex vivo in primary human peripheral blood mononuclear cells ( 1 ). It also protected guinea pig arteries from impaired functional responses and morphological changes due to an atherogenic diet ( 2 ). Its primary constituents include lignans and phenolic acids, including p-coumaric and protocatechuic acids ( 1 ).…”

mentioning

confidence: 99%

Cardioprotective effects of silver fir (Abies alba) extract in ischemic-reperfused isolated rat hearts

Drevenšek

Lunder

Benković

et al. 2016

Food & Nutrition Research

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BackgroundSilver fir trunk extract (SFTE) is a complex mixture of antioxidative polyphenols (lignans and phenolic acids) from the trunks of silver fir trees (Abies alba, lignum). In our previous study, we have shown that SFTE exerts strong antioxidative and protective effects against atherogenic, diet-induced arterial wall damage.ObjectiveThe aim of the present study was to test the potential protective effects of SFTE and its compounds, two phenolic acids (p-coumaric and protocatechuic acids) in ischemia–reperfusion injury of isolated rat hearts.DesignIsolated hearts of Wistar rats aged 4–8 weeks were exposed to perfusion, ischemia, and reperfusion periods. The experiments were performed using the following five groups: control, SFTE (10 µg/L), SFTE (100 µg/L), protocatechuic acid, and p-coumaric. Aortas were isolated to measure vascular responses in the presence of Nω-Nitro-L-arginine.ResultsSFTE dose-dependently reduced ischemic-reperfusion heart damage, which was indicated as the decrease in the lactate dehydrogenase (LDH) release rate and arrhythmias duration by 80% and an increase in coronary flow rate during the reperfusion period. Two tested compounds (p-coumaric and protocatechuic acids) acted less cardioprotective, since they decreased the duration of arrhythmias only by 40 and 45%, respectively, and did not decrease LDH release rates during the reperfusion period. Only p-coumaric acid increased coronary flow rates, whereas protocatechuic acid did not.ConclusionsWe conclude that the SFTE exerted the strongest cardioprotective effect, whereas its constituents (the p-coumaric and protocatechuic acids) were less effective in inducing cardioprotection.

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“…Ugotovljeno je bilo tudi, da Belinal učinkovito uravnava raven sladkorja v krvi (Debeljak et al 2016), ščiti žile pred aterosklerozo (nastankom in rastjo oblog v arterijah) (Drevenšek et al 2015) in ščiti srce pred posledicami kapi (Drevenšek et al 2016). Zanimive so tudi raziskave in rezultati vpliva uporabe kreme z ekstraktom bele jelke na izboljšanje kožne funkcije in izgleda (Tavčar 2016).…”

Section: Biologija Gomoljikunclassified

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UVODNIK mag. Špela Planinšek, Gozdarski inštitut Slovenije Leto je za gozdarje, ki delamo na področju vzgoje in izobraževanja javnosti, minilo v sozvočju z Mednarodnim dnem gozdov. Vsako leto je izbrana ena glavna tema in tokrat je bila posvečena prikazu vloge gozda v procesu izobraževanja za trajnostni razvoj. Kako pa se je leto 2019 za slovenske gozdne pedagoge začelo? V celjskem mestnem gozdu, na velikem dogodku pod drevesno hišo! Slika 1: Mnogo ljudi je povabilo v gozd vzelo zares. In ni jim bilo žal.

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Silver fir (Abies alba) trunk extract protects guinea pig arteries from impaired functional responses and morphology due to an atherogenic diet

Cited by 14 publications

References 25 publications

Affordable Production of Antioxidant Aqueous Solutions by Hydrodynamic Cavitation Processing of Silver Fir (<em>Abies Alba</em> Mill.) Needles

Affordable Production of Antioxidant Aqueous Solutions by Hydrodynamic Cavitation Processing of Silver Fir (<em>Abies Alba</em> Mill.) Needles

Cardioprotective effects of silver fir (Abies alba) extract in ischemic-reperfused isolated rat hearts

Nekaj zdravega, sladkega in užitnega iz gozda

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