The lost correlation between heat shock protein 70 (HSPA1A) and plasminogen activator inhibitor-1 in patients with type 2 diabetes and albuminuria

Abstract

We aimed to study the relation between plasma levels of stress-induced heat shock protein 70 (HSPA1A) with plasminogen activator inhibitor-1 (PAI-1) and highdensity lipoprotein cholesterol (HDL-C), apolipoprotein A1 (Apo-A1), and HDL-C/Apo-A1 ratio. In a matched case-control study on patients with diabetes (40 patients with albuminuria and 40 without albuminuria matched for age, sex, and body mass index), we observed that plasma levels of HSPA1A and PAI-1 are increased in patients with albuminuria (0.55±0.02 vs. 0.77±0.04 ng/ml, p value <0.001 for HSPA1A; 25.9±2 vs. 31.8±2.4 ng/ml, p value <0.05 for PAI-1). There was a significant correlation between HSPA1A and PAI-1 in diabetic patients without albuminuria (r=0.28; p value=0.04), but not in those with albuminuria (r=0.07; p value=0.63). No association was found between HSPA1A and HDL-C, between HSPA1A and Apo-A1, or between HSPA1A and HDL-C/Apo-A1 ratio. We concluded that there is a direct correlation between plasma HSPA1A and PAI-1 levels in patients with diabetes, which is lost when they develop albuminuria.

Absence of a positive correlation between CRP and leptin in rheumatoid arthritis

“…The chaotic behavior that we mentioned for the inflammatory response can have some steady states also, such as health, sustained inflammation with or without the presence of sustained trigger [27] which is also in accordance to our subject. In our studies, in health we observe some physiologic correlations such as leptin and CRP, but in diseases with sustained inflammation such as RA or diabetes mellitus, we observe loss of some physiologic and emergence of pathologic correlations [14, 15, 16, 17]. One other important aspect of chaotic behavior is the possibility that the inflammation can be controlled by intervening at certain points, especially in the early course of the disease [28].…”

“…We previously showed the impact of inflammation on altering the physiological and pathological correlations [14, 15, 16, 17]. It is previously shown that leptin and CRP are correlated in healthy individuals [15, 18], and we reported the lost correlation between CRP and leptin in type 2 diabetes mellitus [15].…”

“…We previously reported the lost correlation between CRP and leptin in patients with type 2 diabetes mellitus [15], in which inflammation is considered to be a cornerstone of the disease. We also previously showed that in patients with type 2 diabetes, physiological correlations between heat shock protein 70 (HSPA1A) and plasminogen activator inhibitor-1 disappear [17] and pathological correlations between heat shock protein 70 and asymmetric dimethylarginine and also leptin and HSP70 emerge [14, 16]. RA is also a chronic disease with considerable baseline inflammation.…”

The synergistic effect of traditional Chinese medicine prescription and rumen‐protected γ‐aminobutyric acid on beef cattle under heat stress

“…Unfortunately, the existing study does not elucidate the clear mechanism for the changes, as it involves various biochemical reactions in the body. However, interestingly, this may be also associated with the synergistic effect of TCM and RP-GABA on antioxidant capacity in beef cattle (Azad et al, 2010;Nargesi et al, 2016).…”

Estudo estrutural-funcional do NBD (>i<Nucleotide Binding Domain>/i<) e do PBD (>i<Peptide Binding Domain>/i<) da proteína HspA1A

“…Adicionalmente, a HspA1A também já foi relatada na inibição da agregação da amilina ou IAPP, associada a diabetes melito tipo 2, reduzindo a resistência à insulina e melhorando os parâmetros clínicos (NARGESI et al, 2016;ROSAS et al, 2016) e no aumento da degradação da proteína TAU, relatado em estudo provavelmente pelo Sistema Ubiquitina Proteassoma e/ou por autofagia, na Doença de Alzheimer (SHAO et al, 2021).…”