For people in the second half of life (aged 50+) struggling with difficulties arising from the normative aging process, religion can be a positive help in adaptation to old age. This adaptation is measured, inter alia, by a high sense of self-dignity. An analysis of literature on the psychology of aging and old age suggests that the influence of religious meaning system on sense of self-dignity may be mediated by wisdom. This study explores the relationship between religious meaning system and sense of self-dignity and wisdom as a potential mediator of this relationship among adults 50+. Longitudinal studies with triplicate measurements were carried out on a sample of 246 Polish individuals aged 50+. The mediation analysis with bias-corrected bootstrapping method confirmed that the relation between religious meaning system and sense of selfdignity is mediated by wisdom. These results suggest that religious meaning system, contributing to the increase of wisdom of adults in the second half of life, has a positive effect on the increase in sense of selfdignity.