The loss of imprinted DNA methylation in mouse blastocysts is inflicted to a similar extent by<i>in vitro</i>follicle culture and ovulation induction

Saenz-de-Juano, María Desemparats; Billooye, Katy; Smitz, Johan; Anckaert, Ellen

doi:10.1093/molehr/gaw013

Cited by 32 publications

(24 citation statements)

References 47 publications

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“…Aggressive ovarian stimulation has effects on the patient's wellbeing, by increasing the risk of ovarian hyperstimulation syndrome (OHSS) (Delvigne, 2009;Rizk, 2009), as well as on the endometrium and the ovaries. There are studies showing an increased likelihood of embryo aneuploidy in connection with aggressive ovarian stimulation, even in patients younger than 35, including post-zygotic segregation errors and maternal segregation errors (Baart et al, 2007;Haaf et al, 2009), as well as having a negative impact on the maintenance of genomic imprints during early embryogenesis (Denomme and Mann, 2012;Fauque et al, 2007;Saenz-de-Juano et al, 2016). It has been shown that in patients belonging to either high or low strata of antimüllerian hormone (AMH) concentration an inverse correlation exists between the daily dose of recombinant human follicle stimulating hormone (rhFSH) used in the stimulation and the proportion of blastocyst formation (Arce et al, 2014).…”

Section: Effects Of Ovarian Stimulation On Embryology Parametersmentioning

confidence: 99%

The Vienna consensus: report of an expert meeting on the development of ART laboratory performance indicators

Apter

Balaban

Campbell

et al. 2017

Reproductive BioMedicine Online

225

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This proceedings report presents the outcomes from an international workshop supported by the European Society of Human Reproduction and Embryology (ESHRE) and Alpha Scientists in Reproductive Medicine, designed to establish consensus on definitions and recommended values for Indicators for the assisted reproductive technology (ART) laboratory. Minimum performance-level values ('competency') and aspirational ('benchmark') values were recommended for a total of 19 Indicators, including 12 Key Performance Indicators (KPIs), five Performance Indicators (PIs), and two Reference Indicators (RIs).

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Section: Effects Of Ovarian Stimulation On Embryology Parametersmentioning

confidence: 99%

The Vienna consensus: report of an expert meeting on the development of ART laboratory performance indicators

Apter

Balaban

Campbell

et al. 2017

Reproductive BioMedicine Online

225

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“…The effect of ovulation induction directly affects the quality of the oocytes obtained, which then affects the clinical outcome of the whole assisted pregnancy therapy. COH includes the processes of follicular recruitment, development, and ovulation, which are usually not completely synchronized [18] . Only by overcoming the factors of nonsynchronization is it possible to obtain high-quality oocytes of the same quality as the dominant follicles in the natural cycle.…”

Section: Discussionmentioning

confidence: 99%

Effects of the Oocyte Maturation Rate on Clinical Outcomes of Conventional IVF and ICSI in Female Patients Aged ≥38 Years

Liu

Yu²,

Li³

et al. 2020

Preprint

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Research Question: The average female reproductive potential peaks at age 25 and then begins to decline. As women are delaying childbearing, the prevalence of infertility has risen, leading to increasing demand for assisted reproductive technology (ART). Oocyte quality remains the most important issue during in vitro fertilization (IVF) cycles. This study investigated the effects of the oocyte maturation rate (OMR) on clinical outcomes of conventional IVF and intracytoplasmic sperm injection (ICSI) in female patients aged ≥38 years. Design: A retrospective analysis of 6562 infertile patients who were treated with IVF/ICSI at the reproductive medicine center of our hospital from January 2011 to December 2017 was performed. According to the oocyte maturity (the ratio of the number of mature oocytes to the number of oocytes) on the day of egg collection, the patients were divided into three groups: group A (oocyte maturity ≤30%, n=422), and group B (oocyte maturity from 30-75%, n=1290), and group C (oocyte maturity ≥75%, n=4850). The patient age, years of infertility years, days of gonadotropin (Gn), Gn dosage, serum luteinizing hormone (LH), estradiol (E2), and progesterone (P) levels on the day of human chorionic Gn (HCG) injection, E2 levels per mature oocyte, E2 levels per oocyte, number of mature oocytes, oocyte recovery rate, fertilization rate, cleavage rate, excellent embryo rate, blastocyst formation rate, pregnancy rate, and live birth rate were compared among the three groups. Results: Factors including age, years of infertility, number of eggs obtained, number of mature eggs, normal fertilization rate, cleavage rate, excellent embryo rate, blastocyst formation rate, pregnancy rate, and live birth rate were all found to be related to oocyte maturity on the day of HCG administration (P<0.05). Conclusions: There is a close relationship between oocyte maturity and embryo quality, and a low OMR may be related to a poor ovarian response or decreased sensitivity to Gn. Therefore, a low OMR may affect the fertilization and embryonic development potential in elderly patients undergoing IVF/ICSI, thus affecting the pregnancy rate.

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“…A recent paper reported the successful production of offspring in mouse infertile model following transplantation of primordial follicles within artificial biomaterial grafts [54]. Several investigators are studying whether deleterious epigenetic events occur in cultured follicles [55,56].…”

Section: • • In Vitro Growth and Maturation Of Folliclesmentioning

confidence: 99%

Where are Oncofertility and Fertility Preservation Treatments Heading in 2016?

Harada

Osuga

2016

Future Oncol.

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An improvement in the survival rates of cancer patients and recent advancements in assisted reproductive technologies have led to remarkable progress in oncofertility and fertility preservation treatments. Although there are several available or emerging approaches for fertility preservation, the limited evidence for each strategy is the greatest concern. In this review, we discuss the concerns on currently available options, and propose new approaches for fertility preservation that may be available in the future.

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The loss of imprinted DNA methylation in mouse blastocysts is inflicted to a similar extent byin vitrofollicle culture and ovulation induction

Abstract: This study received funding by Strategic Research Programs-Groeiers (OZR/2014/97), IWT/TBM/110680 and by UZ Brussel Fonds Willy Gepts (WFWG 2013). There is no conflict of interest.

Cited by 32 publications

References 47 publications

The Vienna consensus: report of an expert meeting on the development of ART laboratory performance indicators

The Vienna consensus: report of an expert meeting on the development of ART laboratory performance indicators

Effects of the Oocyte Maturation Rate on Clinical Outcomes of Conventional IVF and ICSI in Female Patients Aged ≥38 Years

Where are Oncofertility and Fertility Preservation Treatments Heading in 2016?

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The loss of imprinted DNA methylation in mouse blastocysts is inflicted to a similar extent byin vitrofollicle culture and ovulation induction

Abstract: This study received funding by Strategic Research Programs-Groeiers (OZR/2014/97), IWT/TBM/110680 and by UZ Brussel Fonds Willy Gepts (WFWG 2013). There is no conflict of interest.

Cited by 32 publications

References 47 publications

The Vienna consensus: report of an expert meeting on the development of ART laboratory performance indicators

The Vienna consensus: report of an expert meeting on the development of ART laboratory performance indicators

Effects of the Oocyte Maturation Rate on Clinical Outcomes of Conventional IVF&nbsp;and ICSI&nbsp;in Female Patients Aged ≥38 Years

Where are Oncofertility and Fertility Preservation Treatments Heading in 2016?

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Effects of the Oocyte Maturation Rate on Clinical Outcomes of Conventional IVF and ICSI in Female Patients Aged ≥38 Years