“…In HIV-1 infection, chemokine receptors are used as co-receptor for viral entry, the virus hijacks the cytoskeleton machinery to favor integration in the host genome, 67 in the intestine prevents a proper recruitment of these cells into the tissues. 82 On the contrary, is still debated if expression of CCL20 and CXCL10 is maintained or reduced in the intestine during the infection, 66,83,84 probably due to the fact that the intestinal mucosa of Recently, we have shown that T-helper cells expressing the chemokine receptor CCR6 and CXCR3 accumulate in the blood of ART treated HIV-1 infected patients and that their frequency correlates with markers of chronic immune activation. 66 Noteworthy, these cells express normal levels of chemokine receptors, but are not able to migrate in response to chemokines.…”