Insight on the regulation of chemokine activities

Cecchinato, Valentina; Uguccioni, Mariagrazia

doi:10.1002/jlb.3mr0118-014r

Cited by 9 publications

(5 citation statements)

References 88 publications

(138 reference statements)

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“…There have been many high-quality reviews recently that describe the different chemokines, receptors, and the signaling pathways involved in great detail (Stone et al 2017;Cecchinato and Uguccioni 2018;Susek et al 2018;Marcuzzi et al 2018;Mollica Poeta et al 2019) and are highly valuable reads. To differentiate and not be repetitive, this review will focus on chemokine signaling in the context of cancer-stroma communication, and will focus on new discoveries as of 2016.…”

Section: Introductionmentioning

confidence: 99%

Chemokine signaling in cancer-stroma communications

Singh

Gray

2021

J. Cell Commun. Signal.

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Cancer is a multi-faceted disease in which spontaneous mutation(s) in a cell leads to the growth and development of a malignant new organ that if left undisturbed will grow in size and lead to eventual death of the organism. During this process, multiple cell types are continuously releasing signaling molecules into the microenvironment, which results in a tangled web of communication that both attracts new cell types into and reshapes the tumor microenvironment as a whole. One prominent class of molecules, chemokines, bind to specific receptors and trigger directional, chemotactic movement in the receiving cell. Chemokines and their receptors have been demonstrated to be expressed by almost all cell types in the tumor microenvironment, including epithelial, immune, mesenchymal, endothelial, and other stromal cells. This results in chemokines playing multifaceted roles in facilitating context-dependent intercellular communications. Recent research has started to shed light on these ligands and receptors in a cancer-specific context, including cell-type specificity and drug targetability. In this review, we summarize the latest research with regards to chemokines in facilitating communication between different cell types in the tumor microenvironment.

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Section: Introductionmentioning

confidence: 99%

Chemokine signaling in cancer-stroma communications

Singh

Gray

2021

J. Cell Commun. Signal.

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“…Chemokine ligands and receptors are widely expressed throughout organs, tissues, and cells, under physiological as well as pathological conditions (9). They regulate chemotaxis and the stimulation of numerous kinds of populations of leukocytes, and hence, are major controllers of leukocyte traffic (10). Under pathological conditions, chemokines play pivotal roles in broad reactions of inflammatory and immune responses via the chemoattraction of innate plus adaptive immune cells (11).…”

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confidence: 99%

Elevated Serum MCP-1/CCL2 Levels are Linked with Disease Severity in Patients with Fibromyalgia Syndrome

Zhao

Chen

et al. 2019

Balkan Med J

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Background: Elevated levels of monocyte chemotactic protein-1/ chemokine CC motif ligand 2 have been identified in fibromyalgia patients. Aims: To examine the potential association among serum levels of monocyte chemotactic protein-1/chemokine CC motif ligand 2 with disease severity of fibromyalgia. Study Design: Cross-sectional study. Methods: Seventy-nine female patients with fibromyalgia and 75 healthy normal controls were included in our study. Serum levels of monocyte chemotactic protein-1/chemokine CC motif ligand 2 were detected by enzyme-linked immune sorbent assays. The existence of tender points was evaluated based on the standardized manual tender point examination. Pressure pain thresholds at the knees, and bilateral trapezius muscles were measured with an algometer. A visual analog scale and the Revised Fibromyalgia Impact Questionnaire were utilized to assess the degree of pain and functional abilities. Results: Serum levels of monocyte chemotactic protein-1/chemokine CC motif ligand 2 were significantly greater in patients with fibromyalgia compared with healthy controls (151.6±31.9 pg/mL vs 103.3±25.2 pg/mL, p<0.001). Patients with severe fibromyalgia had significantly higher serum levels of chemokine CC motif ligand 2 than patients with mild and moderate fibromyalgia (173.1±21.9 pg/mL vs 151.0.0±35.1 pg/mL, p=0.01). Patients with moderate fibromyalgia revealed markedly augmented serum levels of chemokine CC motif ligand 2 compared with patients with mild fibromyalgia (151.0±35.1 pg/mL vs 133.3±23.9 pg/mL, p=0.03). Serum levels of chemokine CC motif ligand 2 were positively associated with tender point scores (r=0.455, p<0.001). In addition, serum levels of chemokine CC motif ligand 2 were positively associated with pressure pain thresholds in both knees and bilateral trapezius muscles (knees: r=-0.349, p=0.002; trapezius muscles: r=-0.318, p=0.004). Finally, we found elevated serum levels of chemokine CC motif ligand were also positively associated with the visual analog scale (r=0.368, p=0.001), and the Fibromyalgia Impact Questionnaire score (r=0.401, p<0.001). Conclusion: Elevated serum levels of monocyte chemotactic protein-1/chemokine CC motif ligand 2 are linked to disease severity of fibromyalgia. Therapeutic interventions inhibiting monocyte chemotactic protein-1/chemokine CC motif ligand 2 in fibromyalgia deserve additional studies.

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“…After VENN analysis, 122 genes were screened, and they were enriched in chemokine activity and chemokine receptor binding. Chemokines, low molecular chemotactic cytokines, also known as small pro-inflammatory chemoattractant cytokines implicated in mediating connection within disparate cell types, and various biological processes, such as cell adhesion and migration (Cecchinato et al 2018;Tiberio et al 2018). Chemokines and their receptors are the most vital mechanism operating in metastasis, and organ-specific metastasis develops when tumor cells are affected by a chemokine gradient at a distance (Zlotnik et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Immune-based prognostic biomarkers associated with metastasis of osteosarcoma

Peng²,

Wu³

et al. 2023

gpb

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This study aimed to identify immune-based prognostic biomarkers associated with metastasis of osteosarcoma. Based on the GEO and TCGA databases, 437 differentially expressed genes were screened between primary and metastatic osteosarcoma. Weighted gene co-expression network analysis (WGCNA) revealed 496 genes in turquoise module which had the highest correlation with osteosarcoma metastasis. Within these two group genes, 122 common genes involved in osteosarcoma metastasis were identified. These genes were enriched in chemokine activity, chemokine receptor binding, TNF signaling pathway, etc. Survival analysis revealed 8 prognostic genes (ANK3, EGR1, FBP1, FOS, KIFC3, MAOB, ISLR and MFAP4) from the 122 genes. RT-qPCR showed that all of these eight genes were differentially expressed between 143B and MNNG/HOS Cl cells. Various infiltrating immune cells showed significant differences between primary and metastatic osteosarcoma. Expression of all the 8 prognostic genes was correlated with infiltration abundance of multiple immune cells, such as follicular helper T cells, activated dendritic cells. In addition, 10 microRNAs and 7 transcription factors that targeted these prognostic genes were predicted. In conclusion, 8 immune-based prognostic genes associated with osteosarcoma metastasis were identified.

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Insight on the regulation of chemokine activities

Cited by 9 publications

References 88 publications

Chemokine signaling in cancer-stroma communications

Chemokine signaling in cancer-stroma communications

Elevated Serum MCP-1/CCL2 Levels are Linked with Disease Severity in Patients with Fibromyalgia Syndrome

Immune-based prognostic biomarkers associated with metastasis of osteosarcoma

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