The long-term stability and biocompatibility of fluorescent nanodiamond as an in vivo contrast agent

Vaijayanthimala, V.; Cheng, Po Yun; Yeh, Shih Hua; Liu, Kuang Kai; Hsiao, Chêng; Ji, Chao; Chang, Huan‐Cheng

doi:10.1016/j.biomaterials.2012.06.084

Cited by 236 publications

(223 citation statements)

References 47 publications

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“…They have the smallest particle size among different kinds of synthetic diamonds, typically in the range of $10 nm, and exhibit outstanding mechanical, optical, electrical, and thermal properties [1]. This makes DNDs promising in a diversity of areas of science and technology, ranging from the 'conventional' applications such as abrasives, cutting and polishing tools [2,3], to the 'cutting-edge' ones -drug delivery, biomedical imaging, non-toxic contrast agents [4][5][6][7], magnetic sensors [8], composites [9,10], and quantum computing [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

On the relation between chemical composition and optical properties of detonation nanodiamonds

Kirmani

Peng

Mahfouz

et al. 2015

Carbon

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a b s t r a c tThe morphology and presence of impurities strongly influence mechanical, optical, electrical, and thermal properties of detonation nanodiamonds (DNDs). Here we report insights on the chemical composition and its effect on the optical properties of the DNDs obtained by rate-zonal density gradient ultracentrifugation. Herein, for the first time, a detailed valence band structure of as-prepared and oxidized DNDs is reported. Photoemission spectroscopy (PES) measurements demonstrate that the defects, originating from fullerene-like C bonding in the sp 2 shells of the DNDs, are governing the literature-reported loss of the emission spectral features arising from the nitrogen-vacancy (NV) center excitations. X-ray photoelectron spectroscopy (XPS) measurements reveal that nitrogen is present in the DNDs in the form of N-O bonded species located at the surface region/sp 2 shells, while in core of the DND it is in the form of N-C/N@C species.

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Section: Introductionmentioning

confidence: 99%

On the relation between chemical composition and optical properties of detonation nanodiamonds

Kirmani

Peng

Mahfouz

et al. 2015

Carbon

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“…Recently, Rojas et al 20 studied the in vivo biodistribution of detonation nanodiamond labeled with 18 F in rats using positron emission tomography. More recently, Vaijayanthimala et al 21 investigated the long-term stability and biocompatibility of 100 nm FND administered by intraperitoneal injection over 5 months in rats.…”

Section: Introductionmentioning

confidence: 99%

“…Several biocompatibility studies of the particles in vitro with various cell lines have shown that ND is among the least toxic of all the carbon-based nanomaterials tested so far. 41,42 The excellent biocompatibility of the carbon-based nanomaterial (ie, NDs) has been demonstrated recently, 7,21,43,44 which makes it superior to other nanoparticles, such as nanosilica, which has very recently been shown to cause liver injury after continuous intraperitoneal injection 44 in vivo. ND therefore serves as an effective drug carrier in vivo.…”

mentioning

confidence: 99%

In vivo enhancement of anticancer therapy using bare or chemotherapeutic drug-bearing nanodiamond particles

Li¹,

Tong²,

Cao³

et al. 2014

IJN

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Background This study investigated the use of nanodiamond particles (NDs) as a promising material for drug delivery in vivo and in vitro. Methods HepG2 cells (a human hepatic carcinoma cell line) were used to determine the characteristics of a nanodiamond-doxorubicin complex (ND-DOX) when taken up by cells in vitro using laser scanning confocal microscopy and dialysis experiments. We also compared the survival rate and histopathology of tumor-bearing mice after treatment with NDs or ND-DOX in vivo. Results In vitro investigation showed that ND-DOX has slow and sustained drug release characteristics compared with free doxorubicin. In vivo, the survival rate of tumor-bearing mice treated with ND-DOX was four times greater than that of mice treated with free doxorubicin. Interestingly, the survival rate in mice treated with NDs alone was close to that of mice treated with free doxorubicin. This indicates that treatment with ND-DOX can prolong the lifespan of tumor-bearing mice significantly compared with conventional doxorubicin and that NDs can have this effect as well. Histopathological analysis showed that neither the NDs nor ND-DOX were toxic to the kidney, liver, or spleen in contrast with the well-known toxic effects of free doxorubicin on the kidney and liver. Further, both the bare NDs and ND-DOX could suppress tumor growth effectively. Conclusion NDs can potentially prolong survival, and ND-DOX may act as a nanodrug with promising chemotherapeutic efficacy and safety.

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“…They are nontoxic and can be synthesized through scalable fabrication methods, and the biological properties of the nanodiamonds can be tailored (for example, to seek out tumors) by the facile conjugation of biological molecules to their surfaces. [9][10][11][12][13] With the inclusion of NVs in the nanodiamonds, they become stable, bright fluorescent probes (fluorescent nanodiamonds or FNDs) that are an alternative to bleachable organic dyes and toxic quantum dots for biological experiments. 14,15 However, it is the NVs' spin-dependent fluorescence that enables superior spatial resolution compared to fluorescence-based molecular imaging.…”

Section: Nitrogen-vacancies In Nanodiamondmentioning

confidence: 99%

Nanodiamond molecular imaging with enhanced contrast and expanded field of view

Hegyi

Yablonovitch

2013

J. Biomed. Opt

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Abstract. Nanodiamond imaging is a new molecular imaging modality that takes advantage of nitrogen-vacancy (NV) centers in nanodiamonds to image a distribution of nanodiamonds with high sensitivity and high spatial resolution. Since nanodiamonds are nontoxic and are easily conjugated to biomolecules, nanodiamond imaging can potentially elicit physiological information from within a living organism. The position of the nanodiamonds is measured using optically detected electron spin resonance of the NVs. In a previous paper, we described a proof-of-principle nanodiamond imaging system with the ability to image in two dimensions over a 1 × 1 cm field of view and demonstrated imaging within scattering tissue. Here, we describe a second-generation nanodiamond imaging system with a field of view of 30 × 200 mm, and with three-dimensional imaging potential. The new system has a comparable spatial resolution of 1.2 mm FWHM and a sensitivity (in terms of the concentration of carbon atoms in a mm 3 voxel) of 1.6 mM mm 3 Hz −1∕2 , a 3-dB improvement relative to the old system. We show that imaging at 2.872 GHz versus imaging at 2.869 GHz offers a 1.73× improvement in sensitivity with only a 20% decrease in resolution and motivate this by describing the observed lineshape starting from the NV spin Hamiltonian.

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The long-term stability and biocompatibility of fluorescent nanodiamond as an in vivo contrast agent

Cited by 236 publications

References 47 publications

On the relation between chemical composition and optical properties of detonation nanodiamonds

On the relation between chemical composition and optical properties of detonation nanodiamonds

In vivo enhancement of anticancer therapy using bare or chemotherapeutic drug-bearing nanodiamond particles

Nanodiamond molecular imaging with enhanced contrast and expanded field of view

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