The long pentraxin 3 in cardiac surgery: Distinct responses in “on-pump” and “off-pump” patients

Abstract

Operations performed with the use of CPB are associated with a more pronounced release of PTX3 immediately after operation.

Mystery of pentraxin-3 not yet resolved: still a long way to its prime time in surgery

“…Regarding the effect of LMWH, in one study it did not alter ADP-or collagen-induced platelet aggregation during dialysis [6], but in another one no differences between unfractionated heparin and LMWH were observed [7]. The positive impact of LMWH on platelet aggregation, found in our study, could be the result of the reduced microthrombus formation accompanied by less fibrinolytic mechanism activation and fibrinogen fragments production during the HD procedure.…”

“…We randomly enrolled 40 CABG patients to be operated either with the use of CPB or avoiding CPB [6]. Study participants were purposely confined to otherwise healthy subjects in whom an uneventful peri-or postoperative course was expected.…”

Reply

“…The authors found that PTX3 production in whole blood of haemodialysis patients is very slow, increasing only after 48 h and attaining a plateau after 72-96 h. This is in striking contrast not only to myocardial infarction patients [3,4] but also to patients suffering from multiple injuries and/or sepsis, in whom plasma levels of PTX3 peak much earlier, i.e. about 8 h after the onset of the index event, regularly preceding peak levels of CRP [5].…”

Sımultaneous Lung Cancer And Heart Dısease

“…Bu nedenle eş zamanlı kalp damar hastalığı ve akciğer kanseri olgularının doğru bir şekilde değerlendirilmesi tam olarak yapılamamaktadır. 2000'li yıllardan itibaren her iki hastalığın eş zamanlı tedavi protokolleri güncellen-mekte ve çoğunlukla uygulanabilir bulunmaktadır (6)(7)(8) Yayınlarda özellikle kalp akciğer pompası kullanımı, yaklaşım türü ve tümörün pompa aracılığıyla yayılımı değerlendirilmektedir (9)(10)(11)(12)(13)(14)(15).…”