Mystery of pentraxin-3 not yet resolved: still a long way to its prime time in surgery

Kuneš, P; Mandak, Jiri; Koláčková, Martina; Krejsek, Jan

doi:10.1093/ndt/gfn711

Cited by 2 publications

(2 citation statements)

References 7 publications

(13 reference statements)

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“…By examining cellular transcriptome, another endogenous mediator with an indubitable impact on cardiac surgical patients has been recognized [77][78][79] This candidate anti-inflammatory molecule, as yet rather neglected in cardiac surgery, is the long pentraxin-3 (PTX3), itself a fluid-phase pattern recognition receptor (PRR). 80 For all the scarcity of knowledge about its function in surgical patients, including cardiac, we will present our first experience with this interesting molecule. Our conclusions and hypotheses are in keeping with latest findings in non-surgical conditions.…”

Section: Endogenous Anti-inflammatory Mediators and Cellular Transcriptomesmentioning

confidence: 99%

The long pentraxin PTX3: a candidate anti-inflammatory mediator in cardiac surgery

et al. 2013

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Coronary artery bypass grafting (CABG) is performed with the use of cardiopulmonary bypass (CPB) and cardioplegic arrest (CA) of the heart. The advantage of this technique, alternatively referred to as "on-pump" surgery, resides, for the surgeon, in relatively easy access to and manipulation with the non-beating, bloodless heart. However, the advantage that is, thereby, gained by the patient is paid off by an increased susceptibility to postoperative systemic inflammatory response syndrome (SIRS). Under unfavorable conditions, the inflammatory syndrome may develop into life-threatening forms of MODS (multiple organ dysfunction syndrome) or even MOFS (multiple organ failure syndrome). Deliberate avoidance of CPB, also known as "off-pump" surgery, attenuates early postoperative inflammation throughout its trajectory of SIRS→MODS→MOFS, but, in the long run, there appears to be no substantial difference in the overall mortality rates. In the last years, our knowledge of the pathophysiology of surgical inflammation has increased considerably. Recent findings, highlighting the as yet rather obscure role of pentraxin 3 (PTX3) in these processes, are discussed in this review article.

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Section: Endogenous Anti-inflammatory Mediators and Cellular Transcriptomesmentioning

confidence: 99%

The long pentraxin PTX3: a candidate anti-inflammatory mediator in cardiac surgery

et al. 2013

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“…Short PTX is a major acute-phase reactant, the prototype of which is C-reactive protein (CRP) synthesised in the liver. 8 Two forms of PTX3 are preformed and stored in specific granules of neutrophils, and they are then newly synthesised in response to appropriate stimuli and released into the extracellular space by other cells (monocytes, macrophages, dendritic cells, endothelial cells, fibroblasts, and epithelial cells). 9 Circulating neutrophils have a short half-life terminated by apoptotic death, which is necessary for host protection against any undue damage to itself.…”

Section: Introductionmentioning

confidence: 99%

Changes in pentraxin 3 and oxidative parameters during coronary bypass grafting and factors affecting postoperative atrial fibrillation

2020

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Objective The performance of coronary bypass grafting (CBG) induces a type of subclinical systemic inflammatory response syndrome. The present study was performed to examine the changes in pentraxin 3 (PTX3) and oxidative parameters during cross-clamping in patients undergoing CBG. We also examined factors affecting the development of postoperative atrial fibrillation (POAF). Method This study involved 40 patients who underwent elective on-pump CBG (33 men, 7 women; mean age, 60.8 ± 8.0 years). Blood specimens were drawn before anaesthesia and after aortic cross-clamping. POAF was detected by analysing the rhythm records of telemetry units for 96 hours postoperatively. Results The mean PTX3 concentration prior to surgery was 176.3 ± 148.4 pg/mL. After cross-clamping, it increased to 947.7 ± 377.2 pg/mL. The increase was statistically significant. Twelve patients had POAF. The leucocyte count and change in the oxidative stress index were significantly higher in patients without than with POAF. Although the increase in PTX3 was higher in patients without POAF, the difference was not statistically significant. Conclusion The PTX3 concentration significantly increases during CBG. A significant change in the oxidative stress index and a more intense increase in the PTX3 concentration were seen in patients without POAF.

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Mystery of pentraxin-3 not yet resolved: still a long way to its prime time in surgery

Cited by 2 publications

References 7 publications

The long pentraxin PTX3: a candidate anti-inflammatory mediator in cardiac surgery

The long pentraxin PTX3: a candidate anti-inflammatory mediator in cardiac surgery

Changes in pentraxin 3 and oxidative parameters during coronary bypass grafting and factors affecting postoperative atrial fibrillation

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