2014
DOI: 10.1371/journal.pone.0101707
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The Long Noncoding RNA Expression Profile of Hepatocellular Carcinoma Identified by Microarray Analysis

Abstract: BackgroundThousands of long noncoding RNAs (lncRNAs) have been reported in mammalian genomes. These RNAs represent an important subset of pervasive genes involved in a broad range of biological functions. Aberrant expression of lncRNAs is associated with many types of cancers. Here, in order to explore the potential lncRNAs involved in hepatocellular carcinoma (HCC) oncogenesis, we performed lncRNA gene expression profile analysis in 3 pairs of human HCC and adjacent non-tumor (NT) tissues by microarray.Method… Show more

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Cited by 56 publications
(51 citation statements)
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“…Finally, we observed different co-expression patterns in different genomic contexts, suggesting that while a common pattern of co-expression could not be revealed for lncRNAs, this seems to be highly loci-dependent. Contrary to previous studies aimed at the analysis of lncRNAs in HCC [28, 29], which were based on microarray platforms, we performed RNA-seq, which is not biased by probe selection. Moreover, these two previous studies analysed primarily HBV-associated HCCs, while our series contained mostly patients with HCV- or alcohol-associated HCCs.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Finally, we observed different co-expression patterns in different genomic contexts, suggesting that while a common pattern of co-expression could not be revealed for lncRNAs, this seems to be highly loci-dependent. Contrary to previous studies aimed at the analysis of lncRNAs in HCC [28, 29], which were based on microarray platforms, we performed RNA-seq, which is not biased by probe selection. Moreover, these two previous studies analysed primarily HBV-associated HCCs, while our series contained mostly patients with HCV- or alcohol-associated HCCs.…”
Section: Discussionmentioning
confidence: 99%
“…The findings showed deregulation of hundreds of lncRNAs. One study was based on the analysis of five cases of HBV-associated HCC and the second one on the analysis of 3 cases [28, 29]. …”
Section: Introductionmentioning
confidence: 99%
“…Generally, lncRNAs can influence almost every cellular behavior of the central dogma, from transcription to translation by diverse mechanisms including epigenetic alterations, lncRNA-miRNA/DNA interactions, protein-lncRNA interactions and genetic variations [44,[58][59][60][61] (Fig. 2).…”
Section: Functions and Pathways Involving Lncrnas Targetsmentioning
confidence: 99%
“…ZNF674 antisense RNA 1 (ZNF674-AS1, NR_015378), located at Xp11.23, is a novel lncRNA that was identified from a lncRNA microarray analysis [10]. Zhu et al demonstrated for the first time that ZNF674-AS1 was upregulated in 19 pairs of HCC samples compared with adjacent tumor samples [10].…”
Section: Discussionmentioning
confidence: 99%
“…Further, lncRNAs regulate gene expression at the epigenetic, transcriptional, posttranscriptional, and translational levels during cancer development [13, 18]. ZNF674 antisense RNA 1 (ZNF674-AS1, NR_015378) is an lncRNA that was first identified from the lncRNA expression profile of HCC identified by microarray analysis [10]. However, its association with HCC is unclear.…”
Section: Introductionmentioning
confidence: 99%