The long noncoding RNA AATBC promotes breast cancer migration and invasion by interacting with YBX1 and activating the YAP1/Hippo signaling pathway

Wang, Maonan; Dai, Manli; Wang, Dan; Tang, Ting; Xiong, Fang; Xiang, Bo; Zhou, Ming; Li, Xiaoling; Li, Yong; Xiong, Wei; Li, Guiyuan; Zeng, Zhaoyang; Guo, Can

doi:10.1016/j.canlet.2021.04.025

Cited by 26 publications

(11 citation statements)

References 33 publications

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“…2 Despite advancements in early diagnosis and treatment modalities, breast cancer still suffers from high relapse rates and progress rates. 3 Meanwhile, many factors could influence the prognosis of breast cancer patients, such as cancer subtypes (in particular triple-negative breast cancer), no optimal prevention, terrible lifestyle, sub-health, and so on. 4 Consequently, it is critical to characterize promising and novel biomarkers to predict prognosis and further targeted therapy.…”

Section: Introductionmentioning

confidence: 99%

“…8,9 Besides, Wang et al revealed that apoptosis-associated transcript of lncRNA AATBC could facilitate breast cancer invasion and metastasis through activating the YAP1/Hippo signaling routing. 3 Damage-associated molecular pattern molecules (DAMPs) play a possible role in the pathogenesis of aging and cancer, but remain largely unknown. DAMPs, sometimes referred to as alarmins or danger signals, are endogenous molecules and endogenous stressors released by cells in response to exogenous and endogenous stresses, particularly after injury or cell death.…”

Section: Introductionmentioning

confidence: 99%

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Identification of Novel Pyroptosis-Related lncRNAs Associated with the Prognosis of Breast Cancer Through Interactive Analysis

Gao¹,

Li²

2021

CMAR

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Background The role of pyroptosis and lncRNAs in breast cancer remains controversial. This study aimed to explore the pyroptosis-related lncRNAs in breast cancer. Methods All the data used for bioinformatics analysis were downloaded from The Cancer Genome Atlas database. Limma package was used to perform difference analysis, and distinguish mRNA and lncRNA. Survival package was used to conduct prognosis analysis. LASSO algorithm, univariate cox analysis and multivariate cox analysis were used to construct the prognosis model. P value <0.05 was regarded as statistically significant. Results Based on the seven pyroptosis-related lncRNAs tightly associated with patients’ prognosis, a prognostic prediction model was finally developed, which showed powerful effectiveness (Training cohort, one-year AUC = 0.82, 95% Cl = 0.69–0.95, three-year AUC = 0.77, 95% Cl = 0.68–0.85, five-year AUC = 0.74, 95% Cl = 0.66–0.82; Validation cohort, one-year AUC = 0.68, 95% Cl = 0.53–0.84, three-year AUC = 0.72, 95% Cl = 0.64–0.81, five-year AUC = 0.67, 95% Cl = 0.57–0.77). GSEA analysis demonstrated that the protein secretion, angiogenesis, TGF-β signaling and MTORC1 signaling might be involved in the high-risk patients. Moreover, immune infiltration analysis showed that the risk score was positively correlated with Tgd and Th2 cells, yet negatively correlated with CD8+ T cells, cytotoxic cells and T helper cells, which might partly explain the poor prognosis of high-risk patients. Finally, the expression level of seven model lncRNAs in the real world was validated by qRT-PCR using four cancer cell lines (MCF-7, T47D, MDA-MB-231, MDA-MB-469). Conclusion In conclusion, our study identified lncRNAs that are remarkably correlated with patients’ survival and might participate in the pyroptosis process, which might be underlying tumor biomarker and therapeutic targets. This study may provide direction for future research.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Identification of Novel Pyroptosis-Related lncRNAs Associated with the Prognosis of Breast Cancer Through Interactive Analysis

Gao¹,

Li²

2021

CMAR

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“…In fact, both YBX1 and MYL6 are top ranked candidates in mass spectrometry analysis and worth studying. However, the functions of YBX1 were outstanding in other tumors ( 36 – 38 ), which caught our attention. When we downregulated the expression of FOXD3-AS1, the expression of YBX1 was also suppressed in a pre-experiment.…”

Section: Discussionmentioning

confidence: 96%

LncRNA FOXD3-AS1 Promotes the Malignant Progression of Nasopharyngeal Carcinoma Through Enhancing the Transcription of YBX1 by H3K27Ac Modification

et al. 2021

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BackgroundLong noncoding RNAs (lncRNAs) can affect the progression of various tumors, including nasopharyngeal carcinoma (NPC). Here, lncRNA FOXD3-AS1 is highly expressed in NPC tissues through bioinformatics analysis and related to the malignant progression of NPC.MethodsBioinformatics analysis and real-time reverse transcription quantitative PCR(RT-qPCR) assay were applied to identify the expression of FOXD3-AS1 in NPC tissues and cells. Specific short hairpin RNAs (shRNAs) or overexpression plasmids were used to knockdown or upregulate FOXD3-AS1 in NPC cells. The effect of FOXD3-AS1 on proliferation and metastasis of NPC was confirmed by CCK8, colony formation, transwell assays in vitro and mouse tumor growth and metastasis models in vivo, of which the mechanism was explored by RNA pull down, mass spectrometry (MS), RNA Immunoprecipitation (RIP), chromatin immunoprecipitation (CHIP) and luciferase assays.ResultsFOXD3-AS1 was highly expressed in NPC tissues and cells. Knockdown of FOXD3-AS1 significantly inhibited proliferation, migration, and invasion of NPC cells in vitro and vivo. FOXD3-AS1 could specifically bind to YBX1 and have a positive effect on the expression of YBX1. Bioinformatics analysis showed that the promoter of YBX1 had a high enrichment of H3K27ac, which promote mRNA transcription and protein translation of YBX1. Moreover, overexpression of YBX1 could reverse the proliferation, migration and invasion arrest caused by FOXD3-AS1 knockdown.ConclusionLncRNA FOXD3-AS1 is highly expressed and promotes malignant phenotype in NPC, which may provide a new molecular mechanism for NPC.

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“…LncRNAs are important in gene regulation [21]. Many lncRNAs have been shown to be associated with the diagnosis and prognosis of NSCLC [22].…”

Section: Discussionmentioning

confidence: 99%

High Expression of lncRNA HEIH is Helpful in the Diagnosis of Non-Small Cell Lung Cancer and Predicts Poor Prognosis

He¹,

Huang²,

Yang³

et al. 2021

Preprint

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Objective: This study aims to investigate the expression and clinical value of long non-coding RNA (lncRNA) HEIH in peripheral blood of patients with non-small cell lung cancer (NSCLC).Methods: Healthy subjects (N=70), patients with lung squamous cell carcinoma (LUSC, N=70) and patients with lung adenocarcinoma (LUAD, N=80) were included. LncRNA HEIH expression in peripheral blood of included subjects was detected. According to the median expression of lncRNA HEIH, LUSC and LUAD patients were divided into lncRNA HEIH high/low expression group. The correlation between lncRNA HEIH and clinical indicators of patients was analyzed. Receiver-operating characteristic (ROC) curve was used to evaluate the diagnostic efficacy of lncRNA HEIH and carcinoembryonic antigen (CEA) in LUSC and LUAD patients. MedCalc-Comparison of ROC curves was used to compare the area under ROC curve. The cumulative survival rates of lncRNA HEIH high/low expression group were analyzed by Kaplan-Meier curve.Results: LncRNA HEIH in peripheral blood of LUSC and LUAD patients was higher than that in healthy controls, with no evident difference between LUSC and LUAD groups. LUSC and LUAD patients with high lncRNA HEIH expression had larger tumor size, higher CEA level and tumor stage, and higher risk of lymph node metastasis and distal metastasis. LncRNA HEIH had higher diagnostic efficiency than CEA in NSCLC patients. High expression of lncRNA HEIH predicted poor prognosis in patients with NSCLC.Conclusions: High expression of lncRNA HEIH is helpful in the diagnosis of NSCLC and predicts poor prognosis.

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The long noncoding RNA AATBC promotes breast cancer migration and invasion by interacting with YBX1 and activating the YAP1/Hippo signaling pathway

Cited by 26 publications

References 33 publications

Identification of Novel Pyroptosis-Related lncRNAs Associated with the Prognosis of Breast Cancer Through Interactive Analysis

Identification of Novel Pyroptosis-Related lncRNAs Associated with the Prognosis of Breast Cancer Through Interactive Analysis

LncRNA FOXD3-AS1 Promotes the Malignant Progression of Nasopharyngeal Carcinoma Through Enhancing the Transcription of YBX1 by H3K27Ac Modification

High Expression of lncRNA HEIH is Helpful in the Diagnosis of Non-Small Cell Lung Cancer and Predicts Poor Prognosis

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