High Expression of lncRNA HEIH is Helpful in the Diagnosis of Non-Small Cell Lung Cancer and Predicts Poor Prognosis

Abstract

Objective: This study aims to investigate the expression and clinical value of long non-coding RNA (lncRNA) HEIH in peripheral blood of patients with non-small cell lung cancer (NSCLC).Methods: Healthy subjects (N=70), patients with lung squamous cell carcinoma (LUSC, N=70) and patients with lung adenocarcinoma (LUAD, N=80) were included. LncRNA HEIH expression in peripheral blood of included subjects was detected. According to the median expression of lncRNA HEIH, LUSC and LUAD patients were divided into lncRNA HEIH high/low expression group. The correlation between lncRNA HEIH and clinical indicators of patients was analyzed. Receiver-operating characteristic (ROC) curve was used to evaluate the diagnostic efficacy of lncRNA HEIH and carcinoembryonic antigen (CEA) in LUSC and LUAD patients. MedCalc-Comparison of ROC curves was used to compare the area under ROC curve. The cumulative survival rates of lncRNA HEIH high/low expression group were analyzed by Kaplan-Meier curve.Results: LncRNA HEIH in peripheral blood of LUSC and LUAD patients was higher than that in healthy controls, with no evident difference between LUSC and LUAD groups. LUSC and LUAD patients with high lncRNA HEIH expression had larger tumor size, higher CEA level and tumor stage, and higher risk of lymph node metastasis and distal metastasis. LncRNA HEIH had higher diagnostic efficiency than CEA in NSCLC patients. High expression of lncRNA HEIH predicted poor prognosis in patients with NSCLC.Conclusions: High expression of lncRNA HEIH is helpful in the diagnosis of NSCLC and predicts poor prognosis.

LncRNA HEIH expression in cancer prognosis: A review and meta- analysis

“…A total of the 35 articles were obtained by ltering from the four databases mentioned above. After completing the elimination of duplicates and irrelevant study topics, the titles, abstracts and full texts of these studies were read further and 11 articles were nally included in our Meta-analysis [16][17][18][19][20][22][23][24][25][26] . All included studies were from China and Contain a total of 1,227 patients with sample sizes of 35 to 215, and published between 2011 and 2022.…”

“…LncRNA High expression in hepatocellular carcinoma (HEIH), also named as hepatocellular carcinoma upregulated EZH2-associated lncRNA, is a newly identi ed lncRNA and was found to be located at human chromosome chr3q13.31 [15] . In recent years, overexpression of HEIH has been uncovered in a wide range of cancer types, e.g., breast cancer [16] , colorectal cancer [17] , esophageal squamous cell carcinoma [18,19] , gastric cancer [20,21] , retinoblastoma [22] , lung squamous cell carcinoma [23] , lung adenocarcinoma [23] , ovarian cancer [24] , hepatocellular carcinoma [25] and melanoma [26] , and it was found that its overexpression has some prognostic value. In breast cancer, HEIH expression levels was positively correlate with poor prognosis.…”