The long non-coding RNA, urothelial carcinoma associated 1, promotes cell growth, invasion, migration, and chemo-resistance in glioma through Wnt/β-catenin signaling pathway

Zhang, Beilin; Fang, Shaokuan; Cheng, Yingying; Zhou, Chunkui; Deng, Fang

doi:10.18632/aging.102317

Cited by 17 publications

(23 citation statements)

References 38 publications

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“…13 UCA1 plays an oncogenic role in multiple malignancies. [14][15][16][17] Our preliminary studies also showed that knockdown of UCA1 had an inhibitory effect on AML cell proliferation in vitro and tumourigenesis in vivo. LncRNAs also function as crucial regulators of autophagy.…”

supporting

confidence: 55%

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Long non‐coding RNA UCA1 promotes autophagy by targeting miR‐96‐5p in acute myeloid leukaemia

Chen

Wang

et al. 2020

Clin Exp Pharma Physio

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Long non‐coding RNA (lncRNA) urothelial carcinoma‐associated 1 (UCA1) has been identified as an oncogene and is involved in acute myeloid leukaemia (AML). Autophagy contributes to tumourigenesis and cancer cell survival. The purpose of this study was to investigate the regulatory role and mechanism of UCA1 in AML cell viability by its effect on autophagy. The expression of UCA1, miR‐96‐5p, and ATG7 was determined by qRT‐PCR and western blot. Cell proliferation was examined by MTT assay. The autophagy level was assessed by green fluorescent protein (GFP)‐LC3 immunofluorescence and western blot. The interaction between UCA1 and miR‐96‐5p or ATG7 was analyzed by luciferase reporter activity. The results showed that UCA1 promoted AML cell proliferation by inducing autophagy. Mechanistically, UCA1 acted as a sponge of miR‐96‐5p by binding to miR‐96‐5p. ATG7 was a direct target of miR‐96‐5p and positively regulated by UCA1. Further results showed that the miR‐96‐5p mimic effectively counteracted the UCA1 overexpression‐mediated induction of the ATG7/autophagy pathway. Collectively, UCA1 functions as a sponge of miR‐96‐5p to upregulate its target ATG7, thereby resulting in autophagy induction. Our findings reveal a UCA1‐mediated molecular mechanism responsible for autophagy induction in AML and help to improve the understanding of the molecular mechanism of AML progression.

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supporting

confidence: 55%

“…The ceRNA is an important mechanism of lncRNA‐regulated gene function. UCA1 has been identified as an oncogenic lncRNA in diverse malignancies . One important mechanism responsible for the oncogenic functions of UCA1 is its capacity to sponge certain miRNAs by acting as a ceRNA .…”

Section: Discussionmentioning

confidence: 99%

Long non‐coding RNA UCA1 promotes autophagy by targeting miR‐96‐5p in acute myeloid leukaemia

Chen

Wang

et al. 2020

Clin Exp Pharma Physio

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“…When mir-489 was used to treat doxorubicin-, tamoxifen-, or cisplatin-resistant cell lines, it showed significant inhibition of cell proliferation [196]. It was found that mir-489 could directly target ULK1 and LAPTM4B genes, negatively regulate the expression of ULK1 and LAPTM4B, hinder the fusion of autophagosomes and lysosomes, inhibit autophagy, and thus overcome tumors' drug resistance [197][198][199].…”

Section: Microrna and Lncrna Involved In Drug Resistancementioning

confidence: 99%

A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer

Liu

Liao

et al. 2020

Cancers

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The difficulty of early diagnosis and the development of drug resistance are two major barriers to the successful treatment of cancer. Autophagy plays a crucial role in several cellular functions, and its dysregulation is associated with both tumorigenesis and drug resistance. Unc-51-like kinase 1 (ULK1) is a serine/threonine kinase that participates in the initiation of autophagy. Many studies have indicated that compounds that directly or indirectly target ULK1 could be used for tumor therapy. However, reports of the therapeutic effects of these compounds have come to conflicting conclusions. In this work, we reviewed recent studies related to the effects of ULK1 on the regulation of autophagy and the development of drug resistance in cancers, with the aim of clarifying the mechanistic underpinnings of this therapeutic target.

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“…Several studies have demonstrated that UCA1 promotes cell proliferation and EMT in osteosarcoma (38), glioma (81) and papillary thyroid carcinoma (82) by activating the Wnt/β-catenin signaling pathway. In addition, the Wnt/β-catenin signaling pathway is closely associated with chemoresistance (12,81,83). UCA1 induces chemoresistance to cisplatin and temozolomide in glioma and decreases the sensitivity of BC cells to tamoxifen via the Wnt/β-catenin signaling pathway (81,83).…”

Section: Signaling Pathways Regulated By Uca1mentioning

confidence: 99%

Regulatory role of long non‑coding RNA UCA1 in signaling pathways and its clinical applications (Review)

et al. 2021

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Long non-coding RNA metastasis-associated urothelial carcinoma associated 1 (UCA1) plays a pivotal role in various human diseases. Its gene expression is regulated by several factors, including transcription factors, chromatin remodeling and epigenetic modification. UCA1 is involved in the regulation of the PI3K/AKT, Wnt/β-catenin, MAPK, NF-κB and JAK/STAT signaling pathways, affecting a series of cellular biological functions, such as cell proliferation, apoptosis, migration, invasion and tumor drug resistance. Furthermore, UCA1 is used as a novel potential biomarker for disease diagnosis and prognosis, as well as a target for clinical gene therapy. The present review systematically summarizes and elucidates the mechanisms of upstream transcriptional regulation of UCA1, the regulatory role of UCA1 in multiple signaling pathways in the occurrence and development of several diseases, and its potential applications in clinical treatment. Contents1. Introduction 2. Overview of UCA1 3. Upstream regulation of UCA1 expression 4. Signaling pathways regulated by UCA1 5. Clinical applications of UCA1 6. Conclusions and perspective

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The long non-coding RNA, urothelial carcinoma associated 1, promotes cell growth, invasion, migration, and chemo-resistance in glioma through Wnt/β-catenin signaling pathway

Cited by 17 publications

References 38 publications

Long non‐coding RNA UCA1 promotes autophagy by targeting miR‐96‐5p in acute myeloid leukaemia

Long non‐coding RNA UCA1 promotes autophagy by targeting miR‐96‐5p in acute myeloid leukaemia

A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer

Regulatory role of long non‑coding RNA UCA1 in signaling pathways and its clinical applications (Review)

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