The long non-coding RNA SNHG1 promotes glioma progression by competitively binding to miR-194 to regulate PHLDA1 expression

Liu, Liang; Shi, Yan; Shi, Jia; Wang, Haiyang; Sheng, Yujing; Jiang, Qianqian; Chen, Hua; Li, Xiaojian; Dong, Jun

doi:10.1038/s41419-019-1698-7

Cited by 70 publications

(54 citation statements)

References 36 publications

(37 reference statements)

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“…[13][14][15] Decreased expression of miR-194-5p has been reported in various types of malignancy, including glioma, hepatoma carcinoma, gallbladder carcinoma and acute myeloid leukaemia. [16][17][18][19] Overexpressed miR-194-5p in non-small-cell lung cancer suppresses cell migration, invasion and metastasis. 20 These reports indicate that miR-194-5p functions as a tumour suppressor in various human malignancies.…”

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confidence: 99%

Circular RNA USP1 regulates the permeability of blood‐tumour barrier via miR‐194‐5p/FLI1 axis

Gao

et al. 2019

J Cellular Molecular Medi

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Recent studies indicate circular RNAs are related to dysregulation of vascular endothelial cell function, yet the underlying mechanisms have remained elusive. Here, we characterized the functional role of circular RNA USP1 (circ‐USP1) in the regulation of the blood‐tumour barrier (BTB) permeability and the potential mechanisms. In the current study, the circ‐USP1 expressing level was up‐regulated in glioma cerebral microvascular endothelial cells (GECs) of the BTB model in vitro. Knockdown of circ‐USP1 disrupted the barrier integrity, increased its permeability as well as reduced tight junction‐related protein claudin‐5, occludin and ZO‐1 expressions in GECs. Bioinformatic prediction and luciferase assay indicated that circ‐USP1 bound to miR‐194‐5p and suppressed its activity. MiR‐194‐5p contributed to circ‐USP1 knockdown‐induced increase of BTB permeability via targeting and down‐regulating transcription factor FLI1. Furthermore, FLI1 regulated the expressions of claudin‐5, occludin and ZO‐1 in GECs through binding to their promoter regions. Single or combined treatment of circ‐USP1 and miR‐194‐5p effectively promoted anti‐tumour drug doxorubicin across BTB to induce apoptosis of glioma cells. Overall, this present study identified the crucial regulation of circ‐USP1 on BTB permeability via miR‐194‐5p/FLI1 axis‐mediated regulation of tight junction proteins, which might facilitate the development of therapeutics against human gliomas.

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confidence: 99%

Circular RNA USP1 regulates the permeability of blood‐tumour barrier via miR‐194‐5p/FLI1 axis

Gao

et al. 2019

J Cellular Molecular Medi

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“…LncRNAs showed essential roles in glioma progression. [87][88][89] It was found that LINC00909 has a role as a ceRNA by interacting with miR-194 and finally upregulates MUC1-C leading to promote the proliferation and the invasion of glioma cells. Accordingly, LINC00909 upregulation is linked to advanced World Health Organization (WHO) grade, and also poor prognosis in glioma patients.…”

Section: Gliomamentioning

confidence: 99%

“…87 signaling pathway may be a potential therapeutic strategy for glioma patients. 88 In an experimental study, it was observed that suppressing cyclooxygenase-2 (COX-2), microsomal prostaglandin E synthase-1 (mPGES-1), and cytochrome P450 4A11 (CYP4A) in the C6 and U87 glioma cells by flavonoid isoliquiritigenin, inhibited the Akt-FGF-2/TGFβ/VEGF angiogenic signaling pathway through ceRNA effect of lncRNA NEAT1 and miR-194 and could be introduced as a new therapeutic approach for glioma patients. 89 miR-215 was first discovered as a regulator of p53.…”

Section: Gliomamentioning

confidence: 99%

Functional mechanisms of miR‐192 family in cancer

Mishan

Tabari

Parnian

et al. 2020

Genes Chromosomes & Cancer

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By growing research on the mechanisms and functions of microRNAs (miRNAs, miRs), the role of these noncoding RNAs gained more attention in healthcare. Due to the remarkable regulatory role of miRNAs, any dysregulation in their expression causes cellular functional impairment. In recent years, it has become increasingly apparent that these small molecules contribute to development, cell differentiation, proliferation, apoptosis, and tumor growth. In many studies, the miR-192 family has been suggested as a potential prognostic and diagnostic biomarker and even as a possible therapeutic target for several cancers. However, the mechanistic effects of the miR-192 family on cancer cells are still controversial. Here, we have reviewed each family member of the miR-192 including miR-192, miR-194, and miR-215, and discussed their mechanistic roles in various cancers.

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“…Elevated serum levels of miR-194-5p have been associated with cancers of peripheral organs such as the kidneys and liver [104,105]. Interestingly, elevated miR-194-5p in the serum is also associated with promotion of glioma development as well as generalized epilepsy [106,107]. Both miR-22-3p and miR-152-3p have been shown to be differentially expressed in plasma-derived EV miRNA from AD patients [108].…”

Section: Methamphetaminementioning

confidence: 99%

Role of Extracellular Vesicles in Substance Abuse and HIV-Related Neurological Pathologies

Odegaard

Chand

Wheeler

et al. 2020

IJMS

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Extracellular vesicles (EVs) are a broad, heterogeneous class of membranous lipid-bilayer vesicles that facilitate intercellular communication throughout the body. As important carriers of various types of cargo, including proteins, lipids, DNA fragments, and a variety of small noncoding RNAs, including miRNAs, mRNAs, and siRNAs, EVs may play an important role in the development of addiction and other neurological pathologies, particularly those related to HIV. In this review, we summarize the findings of EV studies in the context of methamphetamine (METH), cocaine, nicotine, opioid, and alcohol use disorders, highlighting important EV cargoes that may contribute to addiction. Additionally, as HIV and substance abuse are often comorbid, we discuss the potential role of EVs in the intersection of substance abuse and HIV. Taken together, the studies presented in this comprehensive review shed light on the potential role of EVs in the exacerbation of substance use and HIV. As a subject of growing interest, EVs may continue to provide information about mechanisms and pathogenesis in substance use disorders and CNS pathologies, perhaps allowing for exploration into potential therapeutic options.

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The long non-coding RNA SNHG1 promotes glioma progression by competitively binding to miR-194 to regulate PHLDA1 expression

Cited by 70 publications

References 36 publications

Circular RNA USP1 regulates the permeability of blood‐tumour barrier via miR‐194‐5p/FLI1 axis

Circular RNA USP1 regulates the permeability of blood‐tumour barrier via miR‐194‐5p/FLI1 axis

Functional mechanisms of miR‐192 family in cancer

Role of Extracellular Vesicles in Substance Abuse and HIV-Related Neurological Pathologies

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