The long lasting effects of electrical simulation of the medial preoptic area and medial amygdala on maternal behavior in female rats

Morgan, Hywel; Watchus, Jason; Milgram, Norton W.; Fleming, Alison S.

doi:10.1016/s0166-4328(98)00070-9

Cited by 65 publications

(42 citation statements)

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“…Previous studies of rats have shown that the MPOA was most necessary for the occurrence of the active components of maternal behavior, especially retrieval (Franz et al, 1986;Jakubowski and Terkel, 1986;Numan et al, 1988;Numan, 1990;Lee and Brown, 2002). The reported findings showing that MPOA damage disrupted the operant bar-press response using pups as a rewarding stimulus in rats (Lee et al, 1999), that the preference for a pup-associated cue was enhanced by the electrical stimulation of the MPOA (Morgan et al, 1997(Morgan et al, , 1999, and that temporary inactivation of the MPOA disrupted maternal behavior in postpartum ewes (Perrin et al, 2007) suggest that the MPOA is involved in the general motivation for the maternal behavior rather than in a neural circuit that specifically regulates the retrieval response (Pereira et al, 2008;Numan and Stolzenberg, 2009;Numan and Woodside, 2010). It is most likely that the infanticide observed in this study was induced by the loss of maternal motivation caused by the MPOA damage.…”

Section: Maternal Motivation and Infanticide In Laboratory Micementioning

confidence: 93%

“…Second, expression of c-Fos and FosB proteins, markers of transcriptionally activated neurons, are induced in MPOA neurons during maternal behavior in rats and mice (Calamandrei and Keverne, 1994;Fleming et al, 1994;Numan and Numan, 1994;Brown et al, 1996;Lin et al, 1998a), and c-Fos expression in response to a pup-associated cue is elevated in MPOA neurons even in the absence of pups (Mattson and Morrell, 2005). Third, electrical stimulation on the MPOA facilitates maternal behavior and preference for pup-associated cues (Morgan et al, 1997(Morgan et al, , 1999. Lastly, the MPOA is known to be involved in the hormone-induced peripartum facilitation of maternal behavior in rats.…”

Section: Introductionmentioning

confidence: 99%

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Functional, anatomical, and neurochemical differentiation of medial preoptic area subregions in relation to maternal behavior in the mouse

Tsuneoka

Maruyama

Yoshida

et al. 2013

J of Comparative Neurology

156

197

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In rodents, previous findings indicate critical involvement of the medial preoptic area (MPOA) in the neural control of maternal behavior. However, the specification of the particular MPOA subregions involved in maternal behavior and the identification of the neurochemical phenotype(s) of the essential neurons demands additional study. Therefore, we investigated the chemical neuroanatomy of the essential MPOA subregion for maternal behavior in C57BL/6J female mice. Using the oxytocinergic neurons in the dorsal MPOA as a primary regional marker, we first assessed the distribution of c-Fos-expressing neurons in the MPOA during maternal behavior using immunohistochemistry. Results showed that non-oxytocinergic neurons in the dorsal and ventral MPOA prominently expressed c-Fos during maternal behavior. Then using excitotoxic lesion studies, we determined the specific MPOA area that is necessary for maternal behavior. Bilateral lesions of the central MPOA, where c-Fos was expressed only moderately, effectively disrupted maternal behavior, although lesions to the dorsal and ventral MPOA regions were ineffective. These centrally lesioned females were highly infanticidal irrespective of their previous maternal experience. Neurochemical investigations showed that more than 75% of the c-Fos-expressing neurons in central MPOA were GABAergic. Many of them also expressed galanin, neurotensin, and/or tachykinin2 mRNAs. Finally, the central MPOA was populated by numerous glutamatergic neurons, although only a small percentage of these neurons colocalized with c-Fos. To conclude, the central MPOA is the indispensable subregion for mouse maternal behavior, and GABAergic and/or peptidergic neurons in this area were transcriptionally activated during maternal behavior.

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Section: Maternal Motivation and Infanticide In Laboratory Micementioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Functional, anatomical, and neurochemical differentiation of medial preoptic area subregions in relation to maternal behavior in the mouse

Tsuneoka

Maruyama

Yoshida

et al. 2013

J of Comparative Neurology

156

197

View full text Add to dashboard Cite

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“…Results showed that not only did animals with AMYG lesions have the shortest latency to become maternal, but that they were also less`f earful'' in open-®eld and Y-maze tests, as compared to other groups. Recent work in which maternally experienced females received electrical stimulation of the AMYG, showed the opposite effects: animals took longer to show maternal behavior and were more emotional than non-stimulated controls (Morgan, Watchus, Milgram, and Fleming, 1999). These results suggest that animals receiving AMYG lesions are less neophobic than controls, and thus less fearful of pups as a novel stimulus; in contrast, electrical stimulation of these sites produces the opposite effect.…”

mentioning

confidence: 85%

The effects of medial preoptic area and amygdala lesions on maternal behavior in the juvenile rat

Oxley

Fleming

2000

Dev. Psychobiol.

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The present study was designed to determine whether the medial preoptic area (MPOA) and the amygdala (AMYG) are involved in the expression of ``maternal'' behavior in juvenile rats as they are in the adult. Juveniles show many behaviors that are similar to the maternal behaviors shown by the postpartum female rat. Whether these behaviors are social in function, as opposed to parental, and hence mediated by different mechanisms from those regulating adult maternal behavior is not known. To test the roles of the MPOA and AMYG in mediating these behaviors, 21‐day‐old female juvenile rats received MPOA, AMYG, or SHAM (MPOA/AMYG) lesions and were tested at 22 days of age for maternal and other responses to pups. Major findings demonstrate that MPOA lesions disrupt components of maternal behavior, including retrieving and nest building, while AMYG lesions facilitate these behaviors. These findings indicate striking similarities between the juvenile and rat brain for parental responding. © 2000 John Wiley & Sons, Inc. Dev Psychobiol 37: 253–265, 2000

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“…First, each of the nodes has been implicated in the control of multiple forms of social behavior. These include aggression, appetitive and consummatory sexual behavior, various forms of communication, social recognition, affiliation, bonding, parental behavior and responses to social stressors (Kirkpatrick et al, 1994;Kollack-Walker and Newman, 1995;Bamshad and Albers, 1996;Coolen et al, 1997;Kollack-Walker et al, 1997;Wang et al, 1997;Lonstein et al, 1998;Morgan et al, 1999;Delville et al, 2000;Kalinichev et al, 2000;Gammie and Nelson, 2001;Heeb and Yahr, 2001;Sheehan et al, 2001;Ferguson et al, 2002;Cushing et al, 2003;Lim and Young, 2004). The nodes are also bidirectionally connected (Risold and Swanson, 1997b;Coolen and Wood, 1998;Dong and Swanson, 2004), and each area contains sex steroid receptors that are essential for the sexual differentiation and temporal coordination of social behavior (Morrell and Pfaff, 1978;Commins and Yahr, 1985;Simerly et al, 1990;Wood and Newman, 1995).…”

mentioning

confidence: 99%

The vertebrate social behavior network: Evolutionary themes and variations

Goodson

2005

Hormones and Behavior

713

647

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Based on a wide variety of data, it is now clear that the brains of birds and teleost (bony) fish possess a core "social behavior network" within the basal forebrain and midbrain that is homologous to the social behavior network of mammals. The nodes of this network are reciprocally connected, contain receptors for sex steroid hormones, and are involved in multiple forms of social behavior. Other hodological features and neuropeptide distributions are likewise very similar across taxa. This evolutionary conservation represents a boon for experiments on phenotypic behavioral variation, as the extraordinary social diversity of teleost fish and songbirds can now be used to generate broadly relevant insights into issues of brain function that are not particularly tractable in other vertebrate groups. Two such lines of research are presented here, each of which addresses functional variation within the network as it relates to divergent patterns of social behavior. In the first set of experiments, we have used a sexually polymorphic fish to demonstrate that natural selection can operate independently on hypothalamic neuroendocrine functions that are relevant for 1) gonadal regulation and 2) sex-typical behavioral modulation. In the second set of experiments, we have exploited the diversity of avian social organizations and ecologies to isolate species-typical group size as a quasiindependent variable. These experiments have shown that specific areas and peptidergic components of the social behavior network possess functional properties that evolve in parallel with divergence and convergence in sociality. Keywords sociality; aggression; sexual behavior; communication; vocalization; arginine vasopressin; arginine vasotocin; isotocin; mesotocin; oxytocin; fish; bird; bed nucleus of the stria terminalis; amygdala; lateral septum; anterior hypothalamus; ventromedial hypothalamus; preoptic area; periaqueductal gray; nucleus intercollicularis; c-fos; egr-1; ZenkThe research program described below is designed to address two major goals. The first of these goals is to elucidate evolutionary themes in the neuroendocrine, functional, and connectional organization of brain circuits that regulate social behavior. This will provide a phylogenetically broad framework for examining the neural and neuroendocrine mechanisms of behavior, and will allow detailed and meaningful comparisons to be made across the major vertebrate classes. Building upon this foundation, the second primary goal is to capitalize on the extraordinary behavioral diversity of birds and teleost (bony) fish to elucidate the ways that neural and neuroendocrine mechanisms are adjusted over evolutionary time to produce intraspecific and interspecific variation in behavior. If conducted within a well-characterized, comparative framework, these findings obtained in birds and fish should yield solid predictions for other vertebrates as well. Thus, our work addresses evolutionary themes, as described in the first section below, and variations on those themes, as...

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The long lasting effects of electrical simulation of the medial preoptic area and medial amygdala on maternal behavior in female rats

Cited by 65 publications

References 33 publications

Functional, anatomical, and neurochemical differentiation of medial preoptic area subregions in relation to maternal behavior in the mouse

Functional, anatomical, and neurochemical differentiation of medial preoptic area subregions in relation to maternal behavior in the mouse

The effects of medial preoptic area and amygdala lesions on maternal behavior in the juvenile rat

The vertebrate social behavior network: Evolutionary themes and variations

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