We present a growth tectonic model of Earth's inner core and the resulting model of the seismic anisotropy. The inner core grows anisotropically if the convection in the outer core is of Taylor column type. The anisotropic growth produces a flow field of the poloidal zonal order 2 type as a result of the isostatic adjustment of the viscous inner core. Crystals in the inner core align themselves under the stress field produced by the flow. We model the anisotropic structure of the inner core, using the theory of Kamb [1959] and elastic constants of Stixrude and Cohen [1995b]. We consider models for both hcp iron and fcc iron, which are the probable crystal structures for the inner core iron according to Stixrude and Cohen [1995a]. We have found that the c axis for hcp iron and [111] direction for fcc iron align in the polar direction. The alignment is consistent with seismic observations, which have revealed that the P wave velocity is faster in the polar direction. Our model predicts that the degree of the alignment decreases near the inner core boundary in accord with recent body wave observations. The radial dependence of the alignment would result from the following three effects: (1) crystals near the surface have not undergone stressed state long enough to acquire anisotropy after precipitation, (2) stress near the surface is different from that in the interior of the inner core due to shear stress free boundary condition, and (3) partially molten structure results in transversely isotropic stress condition near the inner core surface due to compaction. Thus the application of Kamb's theory successfully explains the seismic anisotropy in the inner core provided that the crystals have been subjected under the same stress condition for the timescale of the order of 109 years.

In rodents, previous findings indicate critical involvement of the medial preoptic area (MPOA) in the neural control of maternal behavior. However, the specification of the particular MPOA subregions involved in maternal behavior and the identification of the neurochemical phenotype(s) of the essential neurons demands additional study. Therefore, we investigated the chemical neuroanatomy of the essential MPOA subregion for maternal behavior in C57BL/6J female mice. Using the oxytocinergic neurons in the dorsal MPOA as a primary regional marker, we first assessed the distribution of c-Fos-expressing neurons in the MPOA during maternal behavior using immunohistochemistry. Results showed that non-oxytocinergic neurons in the dorsal and ventral MPOA prominently expressed c-Fos during maternal behavior. Then using excitotoxic lesion studies, we determined the specific MPOA area that is necessary for maternal behavior. Bilateral lesions of the central MPOA, where c-Fos was expressed only moderately, effectively disrupted maternal behavior, although lesions to the dorsal and ventral MPOA regions were ineffective. These centrally lesioned females were highly infanticidal irrespective of their previous maternal experience. Neurochemical investigations showed that more than 75% of the c-Fos-expressing neurons in central MPOA were GABAergic. Many of them also expressed galanin, neurotensin, and/or tachykinin2 mRNAs. Finally, the central MPOA was populated by numerous glutamatergic neurons, although only a small percentage of these neurons colocalized with c-Fos. To conclude, the central MPOA is the indispensable subregion for mouse maternal behavior, and GABAergic and/or peptidergic neurons in this area were transcriptionally activated during maternal behavior.

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We report the presence of neural crest-derived corneal precursors (COPs) that initiate spheres by clonal expansion from a single cell. COPs expressed the stem cell markers nestin, Notch1, Musashi-1, and ABCG2 and showed the side population cell phenotype. COPs were multipotent with the ability to differentiate into adipocytes, chondrocytes, as well as neural cells, as shown by the expression of ␤-III-tubulin, glial fibrillary acidic protein, and neurofilament-M. COP spheres prepared from E/nestin-enhanced green fluorescent protein (EGFP) mice showed induction of EGFP expression that was not originally observed in the cornea, indicating activation of the neural-specific nestin second intronic enhancer in culture. COPs were Sca-1؉ , CD34 ؉ , CD45 ؊ , and c-kit ؊ . Numerous GFP ؉ cells were observed in the corneas of mice transplanted with whole bone marrow of transgenic mice ubiquitously expressing GFP; however, no GFP ؉ COP spheres were initiated from these mice. On the other hand, COP spheres from transgenic mice encoding P0-Cre/Floxed-EGFP as well as Wnt1-Cre/Floxed-EGFP were GFP ؉ , indicating the neural crest origin of COPs, which was confirmed by the expression of the embryonic neural crest markers Twist, Snail, Slug, and Sox9. Taken together, these data indicate the existence of neural crestderived, multipotent stem cells in the adult cornea. STEM

Our study has demonstrated for the first time that the infant calming response to maternal carrying is a coordinated set of central, motor, and cardiac regulations and is a conserved component of mammalian mother-infant interactions. Our findings provide evidence for and have the potential to impact current parenting theory and practice, since unsoothable crying is the major risk factor for child abuse.

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