The long and winding road of COVID‐19 in survivors of hospitalisation: Symptoms trajectory and predictors of long COVID

Dias, Murilo B.; Medeiros, Ana Paula V.; de Melo, Sarah S.; Fonseca, Cecilia S.; Jacob‐Filho, Wilson; Avelino‐Silva, Thiago J.; Aliberti, Márlon J. R.; ,

doi:10.1111/joim.13583

Cited by 9 publications

(13 citation statements)

References 14 publications

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“…The PRISMA flowchart for study selection is available in eFigure 1 in Supplement 1. The Table summarizes the population cohorts and the study design characteristics of all the included studies . Of the 41 observational studies, 30 were ranked as high quality and 11 moderate quality on the Newcastle-Ottawa Scale (eTable 1 in Supplement 1).…”

Section: Resultsmentioning

confidence: 99%

Risk Factors Associated With Post−COVID-19 Condition

et al. 2023

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ImportancePost−COVID-19 condition (PCC) is a complex heterogeneous disorder that has affected the lives of millions of people globally. Identification of potential risk factors to better understand who is at risk of developing PCC is important because it would allow for early and appropriate clinical support.ObjectiveTo evaluate the demographic characteristics and comorbidities that have been found to be associated with an increased risk of developing PCC.Data sourcesMedline and Embase databases were systematically searched from inception to December 5, 2022.Study SelectionThe meta-analysis included all published studies that investigated the risk factors and/or predictors of PCC in adult (≥18 years) patients.Data Extraction and SynthesisOdds ratios (ORs) for each risk factor were pooled from the selected studies. For each potential risk factor, the random-effects model was used to compare the risk of developing PCC between individuals with and without the risk factor. Data analyses were performed from December 5, 2022, to February 10, 2023.Main Outcomes and MeasuresThe risk factors for PCC included patient age; sex; body mass index, calculated as weight in kilograms divided by height in meters squared; smoking status; comorbidities, including anxiety and/or depression, asthma, chronic kidney disease, chronic obstructive pulmonary disease, diabetes, immunosuppression, and ischemic heart disease; previous hospitalization or ICU (intensive care unit) admission with COVID-19; and previous vaccination against COVID-19.ResultsThe initial search yielded 5334 records of which 255 articles underwent full-text evaluation, which identified 41 articles and a total of 860 783 patients that were included. The findings of the meta-analysis showed that female sex (OR, 1.56; 95% CI, 1.41-1.73), age (OR, 1.21; 95% CI, 1.11-1.33), high BMI (OR, 1.15; 95% CI, 1.08-1.23), and smoking (OR, 1.10; 95% CI, 1.07-1.13) were associated with an increased risk of developing PCC. In addition, the presence of comorbidities and previous hospitalization or ICU admission were found to be associated with high risk of PCC (OR, 2.48; 95% CI, 1.97-3.13 and OR, 2.37; 95% CI, 2.18-2.56, respectively). Patients who had been vaccinated against COVID-19 with 2 doses had a significantly lower risk of developing PCC compared with patients who were not vaccinated (OR, 0.57; 95% CI, 0.43-0.76).Conclusions and RelevanceThis systematic review and meta-analysis demonstrated that certain demographic characteristics (eg, age and sex), comorbidities, and severe COVID-19 were associated with an increased risk of PCC, whereas vaccination had a protective role against developing PCC sequelae. These findings may enable a better understanding of who may develop PCC and provide additional evidence for the benefits of vaccination.Trial RegistrationPROSPERO Identifier: CRD42022381002

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Section: Resultsmentioning

confidence: 99%

Risk Factors Associated With Post−COVID-19 Condition

et al. 2023

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“…Dear Editor, We thank Dr. Oscar Jolobe for his insightful report [1] in response to our article [2]. Nirmatrelvir has surged as an orally administered antiviral agent that reduces coronavirus replication by inhibiting the SARS-CoV-2 3-chymotrypsin-like cysteine protease [3].…”

Section: Authors Reply: the Long And Winding Road Of Covid-19 In Surv...mentioning

confidence: 99%

“…With millions of people recovering from COVID-19, we now seek preventive measures and treatments that tackle the long-term consequences of COVID-19. Unfortunately, one in eight outpatients with COVID-19 experiences persistent symptoms of the infection, a situation even more common among those admitted to hospitals [2]. It has led the World Health Organization to define long COVID as "a condition characterized by persisting symptoms for at least two months, usually occurring within three months of the infection onset" [2].…”

Section: Authors Reply: the Long And Winding Road Of Covid-19 In Surv...mentioning

confidence: 99%

Authors reply: The long and winding road of COVID‐19 in survivors of hospitalization

2023

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“…Coronavirus Disease 2019 (COVID‐19) can cause multiorgan failure and longer‐term consequences, particularly in patients requiring in‐hospital care 1–4 . Studies indicate that approximately 60% of these patients have persistent symptoms—commonly called “long COVID”—such as fatigue, breathlessness, and joint pain 5–7 . These long‐term effects hinder a smooth transition back to independent living, which encompasses challenges for performing essential self‐care activities 2 .…”

Section: Introductionmentioning

confidence: 99%

“…recovery trajectory for COVID-19 patients, diverging from those of other critically ill patients. 2,7 Evidence shows that postacute intensive rehabilitation can help these patients restore function, avoid hospital readmissions, and improve satisfaction with received care. [3][4][5] Despite such potential benefits, the characteristics of postacute care in patients who have experienced COVID-19 compared to those with other well-known respiratory infections, such as pneumonia caused by influenza or bacterial pathogens, remain unclear.…”

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confidence: 99%

The effectiveness of postacute intensive rehabilitation on severe COVID‐19 patients: A case‐control study

Aliberti,

Levites,

Berardo

2023

Health Science Reports

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Coronavirus Disease 2019 (COVID-19) can cause multiorgan failure and longer-term consequences, particularly in patients requiring inhospital care. [1][2][3][4] Studies indicate that approximately 60% of these patients have persistent symptoms-commonly called "long COVID"-such as fatigue, breathlessness, and joint pain. [5][6][7] These long-term effects hinder a smooth transition back to independent living, which encompasses challenges for performing essential selfcare activities. 2 Although similar manifestations have been documented in patients recovering from other critical illnesses, emerging evidence suggests that severe COVID-19 patients may encounter distinctive challenges. For instance, earlier research reported a higher rate of muscle mass and strength reduction in COVID-19 patients than in other acutely ill individuals. 8 Such findings imply a unique

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The long and winding road of COVID‐19 in survivors of hospitalisation: Symptoms trajectory and predictors of long COVID

Cited by 9 publications

References 14 publications

Risk Factors Associated With Post−COVID-19 Condition

Risk Factors Associated With Post−COVID-19 Condition

Authors reply: The long and winding road of COVID‐19 in survivors of hospitalization

The effectiveness of postacute intensive rehabilitation on severe COVID‐19 patients: A case‐control study

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