The long and the short of it: evidence that <i>FGF5</i> is a major determinant of canine ‘hair’‐itability

Housley, Donna J. E.; Venta, Patrick J.

doi:10.1111/j.1365-2052.2006.01448.x

Cited by 73 publications

(83 citation statements)

References 14 publications

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“…Also, one of the ancestral selection signatures reaches its maximum value close to the INSIG2 gene, recently shown to be associated with milk fatty acid composition in Holstein cattle [46]. Two selection signatures could be related to wool characteristics, one in the CEU group including the FGF5 gene, partly responsible for hair type in the domestic dog [47], [48], and an ancestral selection signature on chromosome 25 in a QTL region associated to wool quality traits in the sheep [49], [50].…”

Section: Resultsmentioning

confidence: 93%

Selection Signatures in Worldwide Sheep Populations

Fariello¹,

et al. 2014

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The diversity of populations in domestic species offers great opportunities to study genome response to selection. The recently published Sheep HapMap dataset is a great example of characterization of the world wide genetic diversity in sheep. In this study, we re-analyzed the Sheep HapMap dataset to identify selection signatures in worldwide sheep populations. Compared to previous analyses, we made use of statistical methods that (i) take account of the hierarchical structure of sheep populations, (ii) make use of linkage disequilibrium information and (iii) focus specifically on either recent or older selection signatures. We show that this allows pinpointing several new selection signatures in the sheep genome and distinguishing those related to modern breeding objectives and to earlier post-domestication constraints. The newly identified regions, together with the ones previously identified, reveal the extensive genome response to selection on morphology, color and adaptation to new environments.

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Section: Resultsmentioning

confidence: 93%

Selection Signatures in Worldwide Sheep Populations

Fariello¹,

et al. 2014

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“…FGF5 also affects hair growth in humans and other animals. A previous study on the sequence analysis of the FGF5 gene in short and long-haired corgis found that the FGF5:p.Cys95Phe mutation appeared to be completely concordant with the long-hair phenotype (Housley and Venta, 2006). Recent studies have indicated that all long-hair-associated mutations follow a recessive mode of inheritance, and allelic heterogeneity of FGF5 mutations causes the long-hair phenotype in dogs (Dierks et al, 2013).…”

Section: Introductionmentioning

confidence: 92%

Cloning, molecular characterization, and expression pattern of FGF5 in Cashmere goat (Capra hircus)

Bao¹,

Yao²,

He³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Fibroblast growth factor 5 (FGF5) is a secreted signaling protein that belongs to the FGF family, and was found to be associated with hair growth in humans and other animals. The Inner Mongolia Cashmere goat (Capra hircus) is a goat breed that provides superior cashmere; this breed was formed by spontaneous mutation in China. Here, we report the cloning, molecular characterization, and expression pattern of the Cashmere goat FGF5. The cloned FGF5 cDNA was 813 base pairs (KM596772), including an open reading frame encoding a 270-amino-acid polypeptide. The nucleotide sequence shared 99% homology with Ovis aries FGF5 (NM_001246263.1). Bioinformatic analysis revealed that FGF5 contained a signal peptide, an FGF domain, and a heparin-binding growth factor/FGF family signature. There was 1 cAMP-and cGMP-dependent protein kinase phosphorylation site, 11 protein kinase C phosphorylation sites, 4 casein kinase II phosphorylation sites, 1 amidation site, 1 N-glycosylation site, and 1 tyrosine kinase phosphorylation site in FGF5. Real-time polymerase chain reaction showed that FGF5 mRNA levels were higher in testis than in the pancreas and liver. These data suggest that FGF5 may play a crucial role in Cashmere goat hair growth.

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“…Such breeds are readily identified from the across-breed SNP genotyping database. It should be possible now to validate the most significant (P # 0.001) of the other loci in Table 2 using breeds in which the implicated SNPs are segregating ½e.g., the locus on CFA 32 for short coat (Table 2) was identified by segregation analysis using dachshunds or corgis (Housley and Venta 2006).…”

Section: Discussionmentioning

confidence: 99%

Single-Nucleotide-Polymorphism-Based Association Mapping of Dog Stereotypes

Jones¹,

Chase

Martin³

et al. 2008

Genetics

137

168

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Phenotypic stereotypes are traits, often polygenic, that have been stringently selected to conform to specific criteria. In dogs, Canis familiaris, stereotypes result from breed standards set for conformation, performance (behaviors), etc. As a consequence, phenotypic values measured on a few individuals are representative of the breed stereotype. We used DNA samples isolated from 148 dog breeds to associate SNP markers with breed stereotypes. Using size as a trait to test the method, we identified six significant quantitative trait loci (QTL) on five chromosomes that include candidate genes appropriate to regulation of size (e.g., IGF1, IGF2BP2 SMAD2, etc.). Analysis of other morphological stereotypes, also under extreme selection, identified many additional significant loci. Less well-documented data for behavioral stereotypes tentatively identified loci for herding, pointing, boldness, and trainability. Four significant loci were identified for longevity, a breed characteristic not under direct selection, but inversely correlated with breed size. The strengths and limitations of the approach are discussed as well as its potential to identify loci regulating the within-breed incidence of specific polygenic diseases.

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The long and the short of it: evidence that FGF5 is a major determinant of canine ‘hair’‐itability

Cited by 73 publications

References 14 publications

Selection Signatures in Worldwide Sheep Populations

Selection Signatures in Worldwide Sheep Populations

Cloning, molecular characterization, and expression pattern of FGF5 in Cashmere goat (Capra hircus)

Single-Nucleotide-Polymorphism-Based Association Mapping of Dog Stereotypes

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