The locoregional recurrence post-mastectomy for ductal carcinoma in situ: Incidence and risk factors

Bannani, Sahar; Rouquette, S.; Bendavid-Athias, Cécile; Tas, Patrick; Lévèque, Jean

doi:10.1016/j.breast.2015.06.005

Cited by 8 publications

(10 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bannani et al also demonstrated that patients under 40 years of age had higher rates of LRR (14.2%) compared with 2.5% in patients over 40 years of age 25. Symptomatic DCIS and premenopausal women have a higher incidence of ER-negative disease that recurs earlier, usually within the first 3 years 29.…”

Section: Discussionmentioning

confidence: 98%

Comparison of Local Recurrence After Simple and Skin-Sparing Mastectomy Performed in Patients with Ductal Carcinoma In Situ

et al. 2016

View full text Add to dashboard Cite

BackgroundThe incidence of ductal carcinoma in situ (DCIS) is increasing with the use of screening mammography, and approximately 30% of all women diagnosed with DCIS are treated by mastectomy. There is increasing use of a skin-sparing mastectomy (SSM) approach to surgically excise DCIS as this facilitates immediate breast reconstruction. The rates of locoregional recurrence (LRR) after simple mastectomy performed for pure DCIS are historically reported as 1%; however, international data suggest that LRR after SSM may be higher.MethodsTo determine our rates of LRR and compare the effect of the type of mastectomy performed, we undertook a retrospective review of all patients who underwent a mastectomy for pure DCIS at our institution between 2000 and 2010. ResultsIn total, 199 patients underwent a mastectomy for pure DCIS (with eight local recurrences), all of which were invasive ductal carcinoma. The recurrences all occurred after SSM, which was associated with a higher 5-year LRR of 5.9% (5/102) compared with 0% in the simple mastectomy group (0/97; p = 0.012), log-rank. Univariate analysis showed the two factors that predicted the risk of recurrence were a young age at mastectomy and close or involved margins.ConclusionsThese data highlight the importance of achieving clear margins, especially in young women with estrogen receptor-negative DCIS who have a higher risk of invasive recurrence. Women undergoing a mastectomy for DCIS should be counseled as to the importance of achieving clear margins and the potential increased need for further excision, post-mastectomy radiotherapy and post-reconstruction mammography in order to prevent LRR after SSM.Electronic supplementary materialThe online version of this article (doi:10.1245/s10434-016-5673-6) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 98%

Comparison of Local Recurrence After Simple and Skin-Sparing Mastectomy Performed in Patients with Ductal Carcinoma In Situ

et al. 2016

View full text Add to dashboard Cite

show abstract

“…In the NSABP B-17 trial, only 6 of the 814 enrolled patients developed metastasis as a first event after treatment with partial mastectomy with or without radiotherapy [28]. Bannani et al [29] reported distant metastasis in 4 of 218 patients treated with mastectomy for DCIS. The low incidence of distant metastasis restricted further statistical analysis.…”

Section: Discussionmentioning

confidence: 99%

Long-term Follow-up of Pure Ductal Carcinoma in situ after Breast-Conserving Surgery

et al. 2019

View full text Add to dashboard Cite

Purpose: Ductal carcinoma in situ (DCIS) is a high-risk disease for the development of invasive tumors. Although it is associated with excellent prognosis, many patients undergo extensive treatment with surgery, radiation, and endocrine therapy. This study evaluated the clinical and pathologic factors associated with invasive recurrence, particularly locoregional, distant disease after breast-conserving surgery (BCS). Methods: This study included 431 patients diagnosed with pure DCIS after BCS between January 2000 and December 2008. The clinicopathological characteristics, margin status, adjuvant therapy, and duration of endocrine therapy were evaluated in hormone receptor-positive DCIS patients. Results: The median duration of follow-up was 115 months. During this period, 37 cases (8.5%) of recurrence were observed (12 in situ and 23 invasive recurrence and 2 unknown cases). There was no distant metastasis as first event. Similarly, none of the initial in situ recurrence cases developed distant metastasis while eight (32%, 8/23) developed distant metastasis after invasive recurrence. Overall recurrence was associated with young age (≤ 40 years) (

show abstract

“…2 There is also ongoing research into the additional effects that exercise has on the general wellbeing for these patients. 1 Methods Through multidisciplinary team input including exercise physiologists, with programs based on Edith Cowan protocols, dieticians, nursing and medical specialists the outcomes of breast cancer patients in the Greater Darling Downs region participating in a 10 week individualised and supervised program have been measured over varying parameters. Parameters such as quality of life data assessed by the DAS 42, aerobic fitness and strength, body measurements (waist and hip circumference) and DEXA scans assessing body weight, fat mass and lean mass have all been collected for each patient.…”

Section: Background and Purposementioning

confidence: 99%

OP4 Incidence of invasive recurrence in DCIS >5cm treated with skin sparing or nipple sparing mastectomy: The Australian experience

Salindera

Snook

Hoffman³

et al. 2020

The Breast

View full text Add to dashboard Cite

model of screening which is stratified according to an individuals' risk would appear logical and this idea has been considered internationally and in Australia for the last few years. How Australian women view this approach is largely unknown however this most acceptable in overseas studies. This study aimed to explore breast screening participants' views of the current program in Victoria, Australia, examine their openness to change and attitudes toward an individualised screening model. This work was designed to inform the development of a decision aid to facilitate women's decisions about participating in individualised screening. Methods A qualitative approach was taken using focus groups that were facilitated in community settings in Melbourne, Victoria. Women were recruited from a population-based breast screening cohort, who are without a personal breast cancer history, and were currently engaged in the public breast screening program offered in Victoria, Australia. Focus group discussion was facilitated following three main themes: 1) experience of breast screening; 2) breast cancer risk perception, and 3) views on individualised screening. Results A total of 52 women participated in one of 4 focus groups and were experienced with screening with 90% of participants having had more than 3 mammograms. They had strong, positive, emotional ties to breast screening in its current structure but were supportive, with some reservations, of the idea of individualised screening. There was good understanding about the factors contributing to personalised risk and a wide range of opinions about the inclusion of genetic testing with genetic testing being considered a foreign and evolving domain. ConclusionsIndividualised breast screening that takes account of risk factors such as mammographic density, lifestyle and genetic factors would be acceptable to a population of women who are invested in the current system. The communication and implementation of a new program would be critical to its acceptance and potential success. Reservations may be had regarding uptake of genetic testing, motivations behind the change and management of the women allocated to a lower risk category. BackgroundSkin sparing (SSM) and nipple sparing mastectomy (NSM) techniques have been critiqued for higher local recurrence rate (LRR) in patients with extensive DCIS, with rates of 5-11% reported. Reported predictors include younger age, high-grade, comedo necrosis present, and involved margins 1 . This study aimed to identify frequency and predictors of loco-regional recurrence for patients undergoing SSM or NSM for DCIS in our practice. Methods Data retrieved using BreastSurgANZ BQA from 2001 to 2018 for patients undergoing NSM or SSM for DCIS >5cm. Cases with microinvasion or previous invasive disease or synchronous contralateral cancer were excluded. Results 603 cases of DCIS treated including 78 tumour with size >5cm undergoing SSM/NSM. Mean follow-up was 74months, mean age 58, mean tumour size 77mm, high-grade in 55, micropapillary archi...

show abstract

The locoregional recurrence post-mastectomy for ductal carcinoma in situ: Incidence and risk factors

Cited by 8 publications

References 34 publications

Comparison of Local Recurrence After Simple and Skin-Sparing Mastectomy Performed in Patients with Ductal Carcinoma In Situ

Comparison of Local Recurrence After Simple and Skin-Sparing Mastectomy Performed in Patients with Ductal Carcinoma In Situ

Long-term Follow-up of Pure Ductal Carcinoma in situ after Breast-Conserving Surgery

OP4 Incidence of invasive recurrence in DCIS >5cm treated with skin sparing or nipple sparing mastectomy: The Australian experience

Contact Info

Product

Resources

About