The lncRNA CCAT2 Rs6983267 G Variant Contributes to Increased Sepsis Susceptibility in a Southern Chinese Population

Abstract

Purpose Accumulating evidence demonstrates that genetic susceptibility genes can be used as biomarkers to assess sepsis susceptibility, and genetic variation is associated with susceptibility and clinical outcomes in patients with sepsis and inflammatory disease. Although studies have shown that the lncRNA CCAT2 is involved in inflammatory diseases, it remains unclear whether CCAT2 gene polymorphisms are associated with susceptibility to inflammatory diseases, such as sepsis, in children. Methods We genotyped the rs6983267 CCAT2 polymorphism in 474 cases (pediatric sepsis) and 678 controls using TaqMan methods, and odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the strength of associations. Results Our results indicate that the rs6983267 T > G polymorphism is significantly associated with an increased risk of sepsis in children (TG and TT: adjusted OR = 1.311, 95% CI = 1.016–1.743, GG and TT: adjusted OR = 1.444, 95% CI = 1.025–2.034 dominant model: GG/TG vs TT adjusted OR = 1.362, 95% CI = 1.055–1.756). Furthermore, the risk effect was more pronounced in children younger than 60 months who were male and who had sepsis. Conclusion We found that the CCAT2 gene polymorphism rs6983267 T > G may be associated with an increased risk of pediatric sepsis in southern China. A larger multicenter study should be performed to confirm these results.

The rs8506 TT Genotype in lincRNA-NR_024015 Contributes to the Risk of Sepsis in a Southern Chinese Child Population

“…According to these findings, we considered that LincRNA-NR_024015 might have critical effects on the pathogenesis of sepsis by interacting with VEGF. In recent years, some studies have suggested that polymorphisms of the genetic components including inflammatory mediators and lncRNAs were markedly associated with the susceptibility of human sepsis (21)(22)(23)(24)(25)(26)(27). Nevertheless, whether the polymorphism of lincRNA-NR_024015 can affect sepsis susceptibility is still unknown.…”

LNC-ZNF33B-2:1 gene rs579501 polymorphism is associated with organ dysfunction and death risk in pediatric sepsis

“…Whether SNPs in lncRNAs can be biomarkers for sepsis susceptibility remains unclear. Several studies have reported that some lncRNAs, such as those in SOX2OT , CCAT2 , and MALAT1 gene polymorphism, may be associated with an increased risk of sepsis ( Chen et al, 2018 ; Wu et al, 2020 ; Wu et al, 2021 ). Lnc-ZNF33B-2:1, also known as LOC283820/AL022334.7-001/NR_136644.1/ENST00000568976 , rs579501 located on chromosome chr10: 43246795 (GRCh37.…”