The rs8506 TT Genotype in lincRNA-NR_024015 Contributes to the Risk of Sepsis in a Southern Chinese Child Population

Li, Jinqing; Zhou, Huazhong; Wei, Bing; Che, Di; Xu, Yufen; Pi, Lei; Fu, Lanyan; Ji, Hong; Gu, Xiaoqiong

doi:10.3389/fpubh.2022.927527

Cited by 1 publication

(1 citation statement)

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“…The severity of organ failure, inflammation and early shock in severe sepsis have also been associated with increased levels of asymmetrical dimethyl arginine (ADMA), which may be influenced by the dimethylarginine dimethylaminohydrolase II gene polymorphism [ 51 ]. Disruptions in the cytokine-inducible SRC homology 2 domain protein pathway due to genetic variants may increase the risk of death in patients with sepsis [ 52 ], and the LincRNA-NR_024015 rs8506 TT genotype has been associated with an increased risk of sepsis [ 53 ].…”

Section: Reviewmentioning

confidence: 99%

Genetic polymorphisms, biomarkers and signaling pathways associated with septic shock: from diagnosis to therapeutic targets

Wu,

Mi,

Liu

et al. 2024

Burns &Amp; Trauma

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Septic shock is a severe form of sepsis characterized by high global mortality rates and significant heritability. Clinicians have long been perplexed by the differential expression of genes, which poses challenges for early diagnosis and prompt treatment of septic shock. Genetic polymorphisms play crucial roles in determining susceptibility to, mortality from, and the prognosis of septic shock. Research indicates that pathogenic genes are known to cause septic shock through specific alleles, and protective genes have been shown to confer beneficial effects on affected individuals. Despite the existence of many biomarkers linked to septic shock, their clinical use remains limited. Therefore, further investigation is needed to identify specific biomarkers that can facilitate early prevention, diagnosis and risk stratification. Septic shock is closely associated with multiple signaling pathways, including the toll-like receptor 2/toll-like receptor 4, tumor necrosis factor-α, phosphatidylinositol 3-kinase/protein kinase B, mitogen-activated protein kinase, nuclear factor κB, Janus kinase/signal transducer and activator of transcription, mammalian target of rapamycin, NOD-like receptor thermal protein domain-associated protein 3 and hypoxia-induced-factor-1 pathways. Understanding the regulation of these signaling pathways may lead to the identification of therapeutic targets for the development of novel drugs to treat sepsis or septic shock. In conclusion, identifying differential gene expression during the development of septic shock allows physicians to stratify patients according to risk at an early stage. Furthermore, auxiliary examinations can assist physicians in identifying therapeutic targets within relevant signaling pathways, facilitating early diagnosis and treatment, reducing mortality and improving the prognosis of septic shock patients. Although there has been significant progress in studying the genetic polymorphisms, specific biomarkers and signaling pathways involved in septic shock, the journey toward their clinical application and widespread implementation still lies ahead.

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Section: Reviewmentioning

confidence: 99%