The lipid-chemical features of the metastatic tissues into the liver from the human gastric cancer, large intestinal cancer and malignant insulinoma.

Nakazawa, Ichiro; Ohtsuki, Masao; Gotō, Yoshio

doi:10.1620/tjem.126.95

Cited by 8 publications

(5 citation statements)

References 11 publications

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“…72 Furthermore, elevations in palmitoleic acid levels appear to be associated with some cancers. [73][74][75] Palmitoleic acid has been reported to be an inducer of leukemic cell differentiation 76 and an inhibitor of Ehrlich ascite tumor cell shrinkage. 77 In addition, elevated palmitoleic acid levels have been observed in metastatic gastric tumors as opposed to gastric primary lesions.…”

Section: Discussionmentioning

confidence: 99%

“…77 In addition, elevated palmitoleic acid levels have been observed in metastatic gastric tumors as opposed to gastric primary lesions. 75 Finally, elevated membrane phospholipid palmitoleic acid levels have been observed in breast tumors with poor histoprognostic grade. 78 The significant and pronounced elevations in prostatic tissue palmitoleic acid levels in cancer as opposed to hyperplasia patients in the present study, therefore, support findings linking palmitoleic acid elevations with cancer.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prostate cancer vs hyperplasia: relationships with prostatic and adipose tissue fatty acid composition

Mamalakis¹,

Kafatos²,

Kalogeropoulos³

et al. 2002

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prostate cancer vs hyperplasia: relationships with prostatic and adipose tissue fatty acid composition

Mamalakis¹,

Kafatos²,

Kalogeropoulos³

et al. 2002

Prostaglandins, Leukotrienes and Essential Fatty Acids

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“… observed transient focal hepatic steatosis in type 1 diabetic patients treated with CPII via an implantable pump, when the catheter became adhered to the liver capsule by fibrosis. Focal steatosis has also been described in insulinoma liver metastasis or after hepatic islets grafts . In these cases, no deleterious effect on long‐term liver function was observed and focal steatosis was reversible on resumption of insulin therapy.…”

Section: Introductionmentioning

confidence: 93%

Portal or subcutaneous insulin infusion: efficacy and impact on liver inflammation

Dal

Jeandidier

Schaschkow

et al. 2015

Fundamemntal Clinical Pharma

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Intraperitoneal insulin allows physiological portal insulin administration and first-pass hepatic insulin extraction, but the impact on liver metabolism and inflammation is unknown. Our objective was to compare the impact, on metabolic control and liver function, of the same dose of insulin administered either intraperitoneally or subcutaneously during continuous infusion in diabetic rats. Wistar rats were randomly divided into 4 groups: control (C), untreated diabetic (streptozotocin, 100 mg/kg) and diabetic rats treated by continual subcutaneous Insuplant® infusion (CSII) and continual intraperitoneal Insuplant(®) infusion (CPII) of 2 UI/200 g/day (via an osmotic mini-pump for 1-4 weeks). Insulin signalling pathways were analysed through hepatic expression of growth hormone receptor and phosphorylated insulin receptor substrate 1. Metabolic control was determined by measurement of body weight, blood glucose and fructosamine. Liver function was assessed by measuring insulin-like growth factor-1 (IGF-1), with global inflammation assessed by levels of alpha-2-macroglobulin (α2M) and lipid peroxidation in plasma. Liver inflammation was evaluated by quantification of hepatic macrophage infiltration and reactive oxygen species production. CPII induced a better improvement in metabolic control and liver function than CSII, producing a significant decrease in blood glucose and fructosamine, coupled with increased IGF-1 and hepatic glycogen storage. Moreover, liver oxidative stress and liver inflammation were reduced. Such observations indicate that the same insulin level in CPII improves glucose control and hepatic glucose metabolism and function, attenuating the hepatic inflammatory response to diabetes. These data demonstrate the importance of focusing on therapeutics to allow first-pass hepatic insulin extraction or prevent diabetic complications.

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“…193 would be owing to the specific tumor cell phenotypes. Nakazawa et al (1978) studied lipid-chemical features of metastatic lesions of human cancer, and recognized a marked change in the phospholipid fatty acid composition of the metastatic lesions in the liver as compared with that of pimary lesions the percentage of the fatty acids which promote membrane lipid fluidity was more increased in the metastatic lesions than in primary lesions. According to Horwitz et al (1974), it had been suggested that polyunsaturated fatty acids of cellular phospholipid may increase the fluidity of cell membrane.…”

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confidence: 99%

A role of the cancer cell membrane fluidity in the cancer metastases: An ESR study.

Nakazawa

Iwaizumi

1989

Tohoku J. Exp. Med.

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AH66F or Yoshida sarcoma (YS) cells were transplanted intraperitoneally into male Donryu rats. Cancer cells obtained from ascites were suspended in saline solution (10' cells ml) after washing. Then, 0.1 ml of each suspension obtained from both strains was injected into the tail vein of 5 rats, respectively. Each metastatic nodule, 1 mm or less in a diameter, thus obtained was then injected into the peritoneal cavity in which these metastatic cells come to free. After 10 days, cancer cells obtained from each ascites were suspended in phosphate buffered saline (Ca2+ and Mg2+ free, pH 7.2) after washing. Each suspension (10' cells/ml) was violently vibrated with a definite amount of 5-doxyl stearic acid and spin labeling of cancer cell membrane was done. Furthermore, each specimen thus obtained was subjected to the electron spin resonance (ESR) measurement and the order parameter was determined from the spectra. In both YS and AH66F strains, the cell membrane fluidity of the metastatic cancer cell was increased at each temperature measured from 5°C through 35°C. The results obtained here suggest that the change of the cell membrane fluidity of cancer cell is closely related with the cancer metastases.cancer ; cell membrane fluidity ; metastases ; ESR ; phospholipid Metastasis to other organ is one of the characteristics of cancer which makes it difficult to cure cancer patients. Therefore, it is desirable to clarify the mechanism of cancer metastasis in order to cure cancer patients. Fidler (1973a) reported that only 1% of B16 melanoma cells injected intravenously had survived to form actual pulmonary metastasis. Fidler (1973b) also succeeded in obtaining the highly metastatic strains of B16 melanoma by means of intravenous injection and tissue culture of the metastatic lesions. Bosmann et al. (1973) noticed the biochemical features of the most highly metastatic strain (F10), that is, the change in the electrophoretic mobility, surface glycoprotein, proteases and increasing degradative enzyme as compared with those of low metastatic B16 melanoma strain (F 1). Miller et al. (1985) suggested that metastasis of human colonic cancer

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The lipid-chemical features of the metastatic tissues into the liver from the human gastric cancer, large intestinal cancer and malignant insulinoma.

Cited by 8 publications

References 11 publications

Prostate cancer vs hyperplasia: relationships with prostatic and adipose tissue fatty acid composition

Prostate cancer vs hyperplasia: relationships with prostatic and adipose tissue fatty acid composition

Portal or subcutaneous insulin infusion: efficacy and impact on liver inflammation

A role of the cancer cell membrane fluidity in the cancer metastases: An ESR study.

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