The lipid accumulation product is a powerful tool to predict metabolic syndrome in undiagnosed Brazilian adults

Nascimento-Ferreira, Marcus Vinicius; Rendo-Urteaga, Tara; Campelo, Regina Célia Vilanova; Carvalho, Heráclito Barbosa; Oliveira, Germano da Paz; Landim, Maurício Batista Paes; Leal, Francisco

doi:10.1016/j.clnu.2016.12.020

Cited by 55 publications

(46 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, individuals with LAP < 34.5 had better metabolic markers than those women with LAP > 34.5, confirming the role of LAP index for identification of metabolic health in postmenopausal women. The cut-off used in our study was close to those adopted by Nascimento Ferreira et al [15]. Interestingly, this cut-off for LAP showed the highest accuracy for metabolic syndrome identification in general population of undiagnosed Brazilian adults [15].…”

Section: Discussionsupporting

confidence: 72%

See 1 more Smart Citation

Reduced Fat Oxidation During Exercise in Post-Menopausal Overweight-Obese Women with Higher Lipid Accumulation Product Index

Stein¹,

Silva²,

Dorneles³

et al. 2018

Exp Clin Endocrinol Diabetes

View full text Add to dashboard Cite

Background and Aims The main aim of this study was to analyze how the lipid accumulation affects the whole-body fat oxidation over a range of intensities during a submaximal incremental exercise test in post-menopausal overweight-obese women. Patients and Methods The maximal fat oxidation (MFO), the intensity where the MFO occurs (FatMax), fat oxidation were measured over a range of intensities during a submaximal incremental exercise test through indirect calorimetry in 60 postmenopausal overweight-obese women (aged>49 years; body mass index 28.0 to 39.0 kg/m²). The metabolic profile of participants was evaluated and the LAP index was calculated (waist-58×triglycerides [mmol/L]). A cutoff point of 34.5 was adopted and participant were designed as low LAP index (n=30) or high LAP index (n=30). Results During submaximal exercise postmenopausal overweight-obese women with low LAP index showed a higher fat oxidation at 50% (0.53±0.05 vs. 0.45±0.12 g/min; p=0.01), 60% (0.40±0.06 vs. 0.31±0.16 g/min; p=0.02) and 70% (0.34±0.08 vs. 0.25±0.15 g/min; p=0.03) of VO2Peak than those with high LAP index. No significant difference was observed in carbohydrate oxidation between groups (p>0.05) during exercise. Moreover, a significant difference in absolute MFO (p=0.018), MFO relative to free fat mass (p=0.043) and FatMax (p=0.002) was identified. Conclusion Postmenopausal overweight-obese women who showed unhealthy metabolic phenotype evaluated through LAP index presented low fat oxidation during a submaximal incremental exercise.

show abstract

Section: Discussionsupporting

confidence: 72%

“…The cut-off used in our study was close to those adopted by Nascimento Ferreira et al [15]. Interestingly, this cut-off for LAP showed the highest accuracy for metabolic syndrome identification in general population of undiagnosed Brazilian adults [15].…”

Section: Discussionsupporting

confidence: 72%

Reduced Fat Oxidation During Exercise in Post-Menopausal Overweight-Obese Women with Higher Lipid Accumulation Product Index

Stein¹,

Silva²,

Dorneles³

et al. 2018

Exp Clin Endocrinol Diabetes

View full text Add to dashboard Cite

show abstract

“…Since its introduction in the literature, LAP has been shown to be a powerful index for identifying metabolic syndrome, insulin resistance, and NAFLD in several cohorts, as well as a reliable marker of CVD risk in women with PCOS [10][11][12][13][14][15][16]. Furthermore, a retrospective study by Ioachimescu et al, has reported that LAP, but not BMI, can predict the all-cause mortality in high CVD risk, non-diabetic patients attending a preventive cardiology clinic [26].…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, in this NHANES cohort, LAP exhibited better correlations with key CVD risk factors (i.e., heart rate and circulating levels of lipids and uric acid) compared to BMI [9]. Subsequently, LAP has been reported as a reliable marker of CVD risk in women with polycystic ovary syndrome (PCOS) and a useful index for recognizing insulin resistance, non-alcoholic fatty liver (NAFLD) and metabolic syndrome in various cohorts [10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 87%

Lipid accumulation product in relation to 10-year cardiovascular disease incidence in Caucasian adults: The ATTICA study

et al. 2018

View full text Add to dashboard Cite

2583 of the 3042 initial participants were reassessed during this follow-up An independent positive association between LAP and long-term CVD incidence in CVD-free Caucasian adults from the general population was revealed. LAP was positively associated with with 10-year CVD incidence, even after adjusting for hypertension, diabetes, hypercholesterolemia, smoking, physical activity, Mediterranean diet adherence, and key pro-inflammatory biomarkers (Hazard Ratios per 10 cm⋅mmol/L of LAP ranging from 1.1 to 1.21, p=0.04). LAP predicted CVD risk better than common obesity indices (BMI, WC, waist-to-hip, waist-to-height ratio). LAP is considered to expand on the concept of the hypertriglyceridemic waist as regards C VD risk

show abstract

“…The logarithmic value of TG-to-HDL-C ratio was calculated as an indicator of LDL particle size, i.e., a zero value of Log (TG/HDL-C) corresponds to a LDL particle diameter of 25.5 nm that delimits normal type A (negative values) from atherogenic type B (positive values) [6]. Lipid accumulation product (LAP) was calculated as follows: LAP = (WC -58)×TG for women, LAP = (WC -65)× G for men, where WCwaist circumference in cm, TG -serum triglyceride level in mmol/l [7].…”

mentioning

confidence: 99%

Hypertriglyceridemia is associated with long-term risk of cardiovascular events and specific comorbidity in very high-risk hypertensive patients

Korolyuk¹,

Radchenko²

2020

Ukr.Biochem.J.

View full text Add to dashboard Cite

although hypertriglyceridemia (hTG) frequently occurs in hypertensive patients and may increase cardiovascular risk, the need for and manner of its reduction remain controversial. The objectives of this study were to compare lipid profiles, parameters of glucose homeostasis, comorbidity, and 5-year survival without cardiovascular events in very high-risk hypertensive (Vhrh) patients with and without hTG, who received moderate intensity atorvastatin therapy. after initial assessment, 107 Vhrh subjects were divided into two groups, i.e., without (n = 49) and with HTG (n = 58). During observation once annually patients were interviewed about prior hospitalizations with further screening for diabetes. combined endpoint included hospitalization due acute myocardial infarction, decompensated heart failure, stroke or death. Survival was analyzed by Kaplan-Meier's method. Nonparametric methods were used for statistical analysis. higher median values of logarithmic value of triglycerides-to-hdl-cholesterol ratio, lipid accumulation product, fasting insulin, and HOMA index were observed in group 2 (P<0.002) that reflect predominance of small dense ldl particles, ectopic lipid deposition and insulin resistance. Patients with hTG more commonly had type 2 diabetes (58.6% vs 34.5%, including first-detected cases during initial assessments and observation, P = 0.02), liver steatosis (81.0% vs 55.1%, P = 0.006), and lithogenic gallbladder disorders (55.2% vs 34.7%, P = 0.05). Women with HTG frequently had a history of hysterovariectomy (55.2% vs 19.0%, Р = 0.018). Despite long-term statin therapy, they often failed to reach recommended ldl-c targets and had worse survival due to significantly higher incidence of combined endpoint (39.6% vs 22.4%, P = 0.027). Further studies are necessary to find safe and effective strategy for secondary prevention in this population. K e y w o r d s: hypertriglyceridemia, very high-risk hypertensive patients, type 2 diabetes, cardiovascular events, atorvastatin therapy.

show abstract

The lipid accumulation product is a powerful tool to predict metabolic syndrome in undiagnosed Brazilian adults

Cited by 55 publications

References 20 publications

Reduced Fat Oxidation During Exercise in Post-Menopausal Overweight-Obese Women with Higher Lipid Accumulation Product Index

Reduced Fat Oxidation During Exercise in Post-Menopausal Overweight-Obese Women with Higher Lipid Accumulation Product Index

Lipid accumulation product in relation to 10-year cardiovascular disease incidence in Caucasian adults: The ATTICA study

Hypertriglyceridemia is associated with long-term risk of cardiovascular events and specific comorbidity in very high-risk hypertensive patients

Contact Info

Product

Resources

About