Reduced Fat Oxidation During Exercise in Post-Menopausal Overweight-Obese Women with Higher Lipid Accumulation Product Index

Abstract

Background and Aims The main aim of this study was to analyze how the lipid accumulation affects the whole-body fat oxidation over a range of intensities during a submaximal incremental exercise test in post-menopausal overweight-obese women. Patients and Methods The maximal fat oxidation (MFO), the intensity where the MFO occurs (FatMax), fat oxidation were measured over a range of intensities during a submaximal incremental exercise test through indirect calorimetry in 60 postmenopausal overweight-obese women (aged>49 years; body mass index 28.0 to 39.0 kg/m²). The metabolic profile of participants was evaluated and the LAP index was calculated (waist-58×triglycerides [mmol/L]). A cutoff point of 34.5 was adopted and participant were designed as low LAP index (n=30) or high LAP index (n=30). Results During submaximal exercise postmenopausal overweight-obese women with low LAP index showed a higher fat oxidation at 50% (0.53±0.05 vs. 0.45±0.12 g/min; p=0.01), 60% (0.40±0.06 vs. 0.31±0.16 g/min; p=0.02) and 70% (0.34±0.08 vs. 0.25±0.15 g/min; p=0.03) of VO2Peak than those with high LAP index. No significant difference was observed in carbohydrate oxidation between groups (p>0.05) during exercise. Moreover, a significant difference in absolute MFO (p=0.018), MFO relative to free fat mass (p=0.043) and FatMax (p=0.002) was identified. Conclusion Postmenopausal overweight-obese women who showed unhealthy metabolic phenotype evaluated through LAP index presented low fat oxidation during a submaximal incremental exercise.

Effects of an Indoor Cycling Program on Cardiometabolic Factors in Women with Obesity vs. Normal Body Weight

“…Our results further indicated that cardiovascular risk parameters were related to the occurrence of an abnormal LAP index, for which the cutoff point was 34.2 cm × mmol/L, above which, the risk of metabolic syndrome is increased [28]. In line with previous literature [29], our results indicate a significantly greater LAP index in the OW group compared to that in the NW group both before and after the intervention, indicating an unhealthy metabolic phenotype for women with obesity. However, women with obesity showed a decrease in LAP in response to IC training (Table 3).…”

Hederagenin Exerts Potential Antilipemic Effect via p38MAPK Pathway in Oleic Acid-induced HepG2 cells and in Hyperlipidemic Rats

“…In the meantime, previous studies had shown that hederagenin could effectively treat tumors through anti-oxidation (Kim et al 2017a) and antiinflammation (Lee et al 2015). Lowering blood lipids is often closely related to properties of antioxidation (Stein et al 2020 (Canesi et al 2019). However, there are no studies have reported that hederagenin can decrease blood lipid.…”

Adipocyte Metabolism and Health after the Menopause: The Role of Exercise

“…Further studies in postmenopausal women have shown that lean women have greater fat oxidation during exercise than obese women. Upon measuring the lipid accumulation index and maximum fat oxidation during submaximal exercise, women with a high lipid accumulation index had 33% lower whole body fat oxidation and 19% lower energy expenditure during exercise than those with a lower lipid accumulation index [ 125 ].…”