The link between genetic variation and variability in vaccine responses: Systematic review and meta-analyses

Posteraro, Brunella; Pastorino, Roberta; Giannantonio, Paolo Di; Ianuale, Carolina; Amore, Rosarita; Ricciardi, Walter; Boccia, Stefania

doi:10.1016/j.vaccine.2014.01.057

Cited by 79 publications

(62 citation statements)

References 52 publications

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“…It should be emphasised that several factors including genetic predisposition [136][137][138], concomitant drugs [139,140], race and sex [141,142] affect vaccine response and influence the risk of adverse event following immunisation.…”

Section: Discussionmentioning

confidence: 99%

On vaccine's adjuvants and autoimmunity: Current evidence and future perspectives

Pellegrino

Clementi

Radice

2015

Autoimmunity Reviews

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Section: Discussionmentioning

confidence: 99%

On vaccine's adjuvants and autoimmunity: Current evidence and future perspectives

Pellegrino

Clementi

Radice

2015

Autoimmunity Reviews

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“…A growing body of literature points to influence of human genetic variability on efficacy as well as tolerability/ adverse effects of a number of vaccines (reviewed in ref. (59,63,71,72)). Specifically, associations of variations in human genes for HLA, cytokines, or cytokine receptors, molecules associated with mounting immune response, have been implicated in determining response to hepatitis B vaccine (73)(74)(75)(76), hepatitis C vaccine (77)(78)(79) as well as a number of childhood vaccines including rubella (80), mumps (81,82), and measles (81)(82)(83), as well as malaria (84).…”

Section: Discussionmentioning

confidence: 99%

“…However, these drugs represent a small fraction of the current and growing list of BTs on the market (10-12). Several technical, logistic, and regulatory factors have been cited as possible barriers (56)(57)(58)(59)(60)(61)(62)(63). Some of these challenges appear to be common both small and large molecule drugs.…”

Section: From Pgx Of Small Molecule Therapeutics To Pgx Of Btsmentioning

confidence: 99%

Recent Advances in Application of Pharmacogenomics for Biotherapeutics

Mahajan

2016

AAPS J

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Abstract.Biotherapeutics (BTs), one of the fastest growing classes of drug molecules, offer several advantages over the traditional small molecule pharmaceuticals because of their relatively high specificity, low off-target effects, and biocompatible metabolism, in addition to legal and logistic advantages. However, their clinical utility is limited, among other things, by their high immunogenic potential and/or variable therapeutic efficacy in different patient populations. Both of these issues, also commonly experienced with small molecule drugs, have been addressed effectively in a number of cases by the successful application of pharmacogenomic tools and approaches. In this introductory article of the special issue, we review the current state of application of pharmacogenomics to BTs and offer suggestions for further expansion of the field.

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“…A recent report also analyzed allelic variant commonalities between vaccines by utilizing systematic review and meta-analysis (Posteraro et al 2014). As a result, four HLA alleles (DRB1*07, DQA1*02:01, DQB1*02:01, and DQB1*03:03) were found to be significantly associated with lower antibody responses to MMR-II, hepatitis B, and influenza vaccines in addition to two HLA alleles (DRB1*13 and DRB1*13:01) associated with high antibody responses (Posteraro et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines

et al. 2014

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Single-nucleotide polymorphisms (SNPs) in candidate immune response genes were evaluated for associations with measles- and rubella-specific neutralizing antibodies, interferon (IFN)-γ, and interleukin (IL)-6 secretion in two separate association analyses in a cohort of healthy immunized subjects. We identified six SNP associations shared between the measles-specific and rubella-specific immune responses, specifically neutralizing antibody titers (DDX58), secreted IL-6 (IL10RB, IL12B), and secreted IFN-γ (IFNAR2, TLR4). An intronic SNP (rs669260) in the antiviral innate immune receptor gene, DDX58, was significantly associated with increased neutralizing antibody titers for both measles and rubella viral antigens post-MMR vaccination (p values 0.02 and 0.0002, respectively). Significant associations were also found between IL10RB (rs2284552; measles study p value 0.006, rubella study p value 0.00008) and IL12B (rs2546893; measles study p value 0.005, rubella study p value 0.03) gene polymorphisms and variations in both measles- and rubella virus-specific IL-6 responses. We also identified associations between individual SNPs in the IFNAR2 and TLR4 genes that were associated with IFN-γ secretion for both measles and rubella vaccine-specific immune responses. These results are the first to indicate that there are SNP associations in common across measles and rubella vaccine immune responses and that SNPs from multiple genes involved in innate and adaptive immune response regulation may contribute to the overall human antiviral response.

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The link between genetic variation and variability in vaccine responses: Systematic review and meta-analyses

Cited by 79 publications

References 52 publications

On vaccine's adjuvants and autoimmunity: Current evidence and future perspectives

On vaccine's adjuvants and autoimmunity: Current evidence and future perspectives

Recent Advances in Application of Pharmacogenomics for Biotherapeutics

Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines

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