2014
DOI: 10.1016/j.vaccine.2014.01.057
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The link between genetic variation and variability in vaccine responses: Systematic review and meta-analyses

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Cited by 79 publications
(62 citation statements)
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“…It should be emphasised that several factors including genetic predisposition [136][137][138], concomitant drugs [139,140], race and sex [141,142] affect vaccine response and influence the risk of adverse event following immunisation.…”
Section: Discussionmentioning
confidence: 99%
“…It should be emphasised that several factors including genetic predisposition [136][137][138], concomitant drugs [139,140], race and sex [141,142] affect vaccine response and influence the risk of adverse event following immunisation.…”
Section: Discussionmentioning
confidence: 99%
“…A growing body of literature points to influence of human genetic variability on efficacy as well as tolerability/ adverse effects of a number of vaccines (reviewed in ref. (59,63,71,72)). Specifically, associations of variations in human genes for HLA, cytokines, or cytokine receptors, molecules associated with mounting immune response, have been implicated in determining response to hepatitis B vaccine (73)(74)(75)(76), hepatitis C vaccine (77)(78)(79) as well as a number of childhood vaccines including rubella (80), mumps (81,82), and measles (81)(82)(83), as well as malaria (84).…”
Section: Discussionmentioning
confidence: 99%
“…However, these drugs represent a small fraction of the current and growing list of BTs on the market (10-12). Several technical, logistic, and regulatory factors have been cited as possible barriers (56)(57)(58)(59)(60)(61)(62)(63). Some of these challenges appear to be common both small and large molecule drugs.…”
Section: From Pgx Of Small Molecule Therapeutics To Pgx Of Btsmentioning
confidence: 99%
“…A recent report also analyzed allelic variant commonalities between vaccines by utilizing systematic review and meta-analysis (Posteraro et al 2014). As a result, four HLA alleles (DRB1*07, DQA1*02:01, DQB1*02:01, and DQB1*03:03) were found to be significantly associated with lower antibody responses to MMR-II, hepatitis B, and influenza vaccines in addition to two HLA alleles (DRB1*13 and DRB1*13:01) associated with high antibody responses (Posteraro et al 2014).…”
Section: Discussionmentioning
confidence: 99%