The link between diabetes and atherosclerosis

Sala, Lucia La; Prattichizzo, Francesco; Ceriello, Antonio

doi:10.1177/2047487319878373

Cited by 142 publications

(126 citation statements)

References 53 publications

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“…Inflammatory signals are at the basis of all chronic diseases, and they are often triggered by dysmetabolic conditions associated with aging, a process widely defined as inflammaging [51][52][53][54]. In an experimental model of prolonged hyperglycemia and cardiomyopathy, high levels of the metastasis-associated lung adenocarcinoma transcript-1 lncRNA (MALAT1) were reported [55].…”

Section: Non-coding Rna and Their Promoter Methylation In Cardiovascumentioning

confidence: 99%

Epigenetic Signaling and RNA Regulation in Cardiovascular Diseases

Mongelli

Atlante

Bachetti

et al. 2020

IJMS

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RNA epigenetics is perhaps the most recent field of interest for translational epigeneticists. RNA modifications create such an extensive network of epigenetically driven combinations whose role in physiology and pathophysiology is still far from being elucidated. Not surprisingly, some of the players determining changes in RNA structure are in common with those involved in DNA and chromatin structure regulation, while other molecules seem very specific to RNA. It is envisaged, then, that new small molecules, acting selectively on RNA epigenetic changes, will be reported soon, opening new therapeutic interventions based on the correction of the RNA epigenetic landscape. In this review, we shall summarize some aspects of RNA epigenetics limited to those in which the potential clinical translatability to cardiovascular disease is emerging.

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Section: Non-coding Rna and Their Promoter Methylation In Cardiovascumentioning

confidence: 99%

Epigenetic Signaling and RNA Regulation in Cardiovascular Diseases

Mongelli

Atlante

Bachetti

et al. 2020

IJMS

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“…For instance, there is a growth of evidence that also showed a higher prevalence of arteriosclerosis in people with diabetes. In addition, numerous observational studies have found increased levels of the mediators of inflammation, such as C-reactive protein, interleukin-6 (IL-6), and plasminogen activator inhibitor 1, to name only a few, as major associative findings between diabetes and atherosclerosis (La Sala et al, 2019). Insulin resistance, a prominent feature of type 2 diabetes mellitus, has been demonstrated as an important risk factor for inducing atherosclerosis among the patients diagnosed with diabetes even in the absence of hyperglycemia (DeFronzo, 2010).…”

Section: Introductionmentioning

confidence: 99%

Brahma-Related Gene 1 Deficiency in Endothelial Cells Ameliorates Vascular Inflammatory Responses in Mice

Zhang

Wang

Song

et al. 2020

Front. Cell Dev. Biol.

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Endothelial dysfunction plays an important role in promoting the progression of disease genesis such as atherosclerosis and abdominal aortic aneurysm (AAA). The physiological unbalance of endothelial cells is a major pathological basis. In this present study, we investigated Brahma-related gene 1 (BRG1), a chromatin remodeling protein, was in mouse models of diabetic atherosclerosis and AAA, focusing on its role in endothelial dysfunction. We report that compared with their wild-type (WT, ApoE–/–; BRG1fl/fl) littermates, endothelium conditional BRG1 knockout mice (CKO, ApoE–/–; BRG1fl/fl; CDH5-cre) exhibited an alleviated phenotype of diabetic atherosclerosis. Immunohistochemically staining and real-time PCR analysis demonstrated fewer macrophages recruitment with a reduction of vascular inflammatory in CKO mice compared with WT mice. Further research in the Ang-II induced AAA model revealed that BRG1 deficiency had the protective effects on endothelium conditional BRG1 deletion, evidenced by the downregulation of pro-inflammatory mediators [interleukin (IL)-1β and IL-6, not tumor necrosis factor-α (TNF-α)] in the vessels of CKO mice compared with WT mice. In Ea.hy926 cell lines, anti-BRG1 small interfering RNA and PFI-3 treatment obviously alleviated tumor necrosis factor-α-induced IL-6 and CCL2 expression, and further research demonstrated that the BRG1 inhibition in endothelial cells not only decreased c-Fos expression but also blocked the c-Fos translocation into nuclei. In conclusion, our results suggest that endothelial BRG1 deficiency may protect the mice from diabetic atherosclerosis and AAA via inhibiting inflammatory response in vessels.

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“…Several observational studies suggest that damages on vascular homeostasis are due to the impact of chronic hyperglycaemia. Likewise, higher levels of the mediators of inflammation, such as C-reactive protein (CRP), interleukin-6 (IL-6), plasminogen activator inhibitor 1 (PAI-1), are observed in diabetic patients suggesting a positive correlation between diabetes and atherosclerosis [3]. Type 2 diabetes is, however, more associated to cardiovascular co-morbidities and mortality comparing to the other types of diabetes mellitus [4,5].…”

Section: Introductionmentioning

confidence: 99%

Impact of Gender Differences and Glycated Haemoglobin on Atherosclerosis Risk in Type 2 Diabetic Patients from North Western Algeria

2020

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In type 2 diabetic patients, blood lipids and lipid ratios have been proven to be associated with atherosclerosis risk; however, results about the effect of gender differences had not been fully conclusive. In this transversal comparative study, a total of 129 adult type 2 diabetic patients (54 men and 75 women), from north western Algeria, was included to highlight the impact of gender differences on atherosclerosis risk (assessed by lipid ratios) according to their diabetic profile. Comparing between the two genders, no significant differences (p>0.05) were noted on diabetes duration, central obesity, body mass index and blood pressures. Moreover, the basic biochemical parameters of both glycaemic and lipid metabolism were not meaningfully divergent. However, higher significant values (p<0.05) of body weight, height, HbA1c levels, HDL and lipid ratios (TC/HDL, LDL/HDL and TG/HDL) were observed in male patients comparing to females. According to the HbA1c levels (HbA1c<7%vs. HbA1c≥ 7%); notable higher CT/HDL, LDL/HDL and TG/HDL in male patients comparing to women were found. The rates of these three lipid ratios were often higher in both classes of HbA1c. The consideration of gender differences is very important for prevention, diagnosis, treatment and management of atherosclerosis and CVD. The disparity in atherogenic risk, in both genders, estimated by lipid ratios need to be critically examined. Further, interventional studies are needed to determine how sex can modulate the impacts of diabetes control parameters on atherosclerosis risk.

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The link between diabetes and atherosclerosis

Cited by 142 publications

References 53 publications

Epigenetic Signaling and RNA Regulation in Cardiovascular Diseases

Epigenetic Signaling and RNA Regulation in Cardiovascular Diseases

Brahma-Related Gene 1 Deficiency in Endothelial Cells Ameliorates Vascular Inflammatory Responses in Mice

Impact of Gender Differences and Glycated Haemoglobin on Atherosclerosis Risk in Type 2 Diabetic Patients from North Western Algeria

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