The Life-Maintaining Effect of Crystalline Progesterone in Adrenalectomized Ferrets

Gaunt, Richard A.; Hays, H. W.

doi:10.1126/science.88.2294.576

Cited by 33 publications

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“…23 Glycogen in the liver and dextrose in the blood are held within normal limits by the carbohydrate in the food. Such animals are to all appearances normal, but they do not possess ability to withstand stress.…”

Section: Function Of the Adrenal Cortexmentioning

confidence: 99%

The Function of the Adrenal Cortex

Kendall¹

1941

JAMA

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The onset of the first bout of fever occurred in the infant under observation exactly fifteen days after the bite. Four days prior to this, twelve days after the bite, the local lesion at the site of the tooth perforations on the hand made its first appearance with the evolution of a deep-seated induration associated with edema of the thumb and index finger and a lymphadenitis involving the epitrochlear and axillary glands. With the onset of the fever a generalized macular erythematous lesion appeared, lasting several days. After an afebrile interval a second bout of fever and erythema occurred, and then, unfortunately, an intercurrent infection of the respiratory tract supervened which terminated in hemorrhagic bronchopneumonia and death.When the first febrile episode occurred an effort was at once made to isolate the specific etiologic factor by animal inoculation, since direct examination of the infant's blood failed to reveal the spirochete. This procedure was successful, and the organism was demonstrated in stained smears of the peripheral blood of the mice inoculated. The organism is a spiral called Spirochaeta morsus muris and was first described by Futaki and his associates.3 It is a short spiral from 2 to 5 microns long with about four curves. The Wassermann reaction may be positive in cases of rat-bite fever but is not consistently so. A positive Kahn reaction was obtained in this child before death, which was due to an intercurrent sepsis. In uncomplicated cases the prognosis is usually good. Therapy is by the use of arsenicals. SUMMARY AND CONCLUSIONS1. An infant Negress aged 11 days was bitten by a rat, and rat-bite fever developed.

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Section: Function Of the Adrenal Cortexmentioning

confidence: 99%

The Function of the Adrenal Cortex

Kendall¹

1941

JAMA

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“…Any prolongation of survival which might be observed as a result of pregnancy in the adrenalectomized animal might perhaps be attributed to the beneficial effects of certain sex hormones rather than to adrenal-like activity; for estrus in dogs and cats (26,27) and progesterone in rats and ferrets (28)(29)(30)(31) have been reported to prolong the survival of adrenal-deficient animals. Actually, however, while the survival of adrenalectomized bitches is reported (3) to be prolonged by pregnancy, a similar report for cats (2) could not be confirmed by other investigators (23,24); and experiments in the white rat (4,25) are also conflicting.…”

Section: Extraction (Fmijre 4)mentioning

confidence: 99%

Pregnancy and Adrenocortical Function: Endocrine Studies of Pregnancy Occurring in Two Adrenal-Deficient Women1

Hills¹,

Venning²,

Dohan³

et al. 1954

J. Clin. Invest.

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“…In the first case it has been shown : (a) that progesterone prolongs the life of adrenalectomized animals [Gaunt & Hays, 1938, working on ferrets; Gaunt, Nelson & Loomis, 1938 ;Bourne, 1939 ;Schwabe & Emery, 1939 ;Tobin, 1939 ;Greene, Wells, & Ivy, 1939, all working on rats ; Corey, 1939, working on cats], an observation which explains the longer survival time of animals adrenalectomized in pregnancy or pseudo-pregnancy [e.g. Rogoff & Stewart, 1927 ;Swingle, Parkins, Taylor, Hays & Morrell, 1937 ;Gaunt & Hays, 1938] and of adrenalectomized animals treated with luteinizing hormone [D'Amour & D'Amour, 1939]; (b) that progesterone causes water and salt retention [Thorn, Nelson, & Thorn, 1938] ; and (c) that progesterone, like cortical extracts, leads to cortical involution [Clausen, 1940]; progesterone, however, unlike cortical hormone, does not affect the work-capacity of adrenalectomized dogs and rats [Waterman, Danby, Gaarenstroom, Spanhoff & Uyldert, 1939;Ingle, 1940]. In the case of the progestational properties of cortical hormone it has been shown that desoxycorticosterone acetate produces a progesta¬ tional reaction in the uterus of the rabbit in doses of 5-10 mg. (i.e.…”

mentioning

confidence: 98%

The Effect of Desoxycorticosterone on the Endometrium of Monkeys

Zuckerman¹

1940

Journal of Endocrinology

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The fact that the properties of progesterone and desoxycorticosterone overlap is indicated on the one hand by experiments which show that progesterone produces some of the specific effects of desoxycorticosterone and on the other by experiments which demonstrate that desoxycorticosterone has a progestational effect on the endometrium. In the first case it has been shown : (a) that progesterone prolongs the life of adrenalectomized animals [

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The Life-Maintaining Effect of Crystalline Progesterone in Adrenalectomized Ferrets

Cited by 33 publications

References 0 publications

The Function of the Adrenal Cortex

The Function of the Adrenal Cortex

Pregnancy and Adrenocortical Function: Endocrine Studies of Pregnancy Occurring in Two Adrenal-Deficient Women1

The Effect of Desoxycorticosterone on the Endometrium of Monkeys

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