The Leydig Cell of a Hypogonadic Rodent (Ellobius lutescens, Th.): Correlation between Ultrastructure and Biosynthetic Activity

Stefan, Y; Steimer, Thierry

doi:10.1095/biolreprod19.4.913

Cited by 6 publications

(5 citation statements)

References 11 publications

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“…In Leydig cells they are observed in the mouse (Christensen and Fawcett, 1966), and in human patients with hypergonadotrophic hypogonadism (Camatini et al, 1981). This syndrome exists naturally in the adult rodent Ellobius, and giant mitochondria very similar to those we observed in the pig were described (Stefan and Steimer, 1978). Hypergonadotrophic hypogonadism is associated with very high LH and low testosterone lev- els.…”

Section: Discussionsupporting

confidence: 79%

Leydig cell development in the pig testis during the late fetal and early postnatal period: An electron microscopic study with attention to the influence of fetal decapitation

Vorstenbosch¹,

Colenbrander²,

Wensing³

1984

Am. J. Anat.

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The ultrastructure of fetal and postnatal pig Leydig cells was studied from 75 days postcoitum (p.c.) to 1 month after birth. Additionally, decapitated fetuses from 75 days p.c. until birth were used to study the effect of deprivation of gonadotrophins on the ultrastructure of Leydig cells. Normal Leydig cell development was characterized by a change in smooth endoplasmic reticulum (SER). Next to branched tubular SER, whirls of elaborate and tightly packed SER membranes appeared. The amount of SER increased with age but decreased slightly before the end of the observation period. Rough endoplasmic reticulum (RER) was a minor component. Large bundles or whirls of intermediate filaments were abundant until just before birth; thereafter, they decreased drastically. Peroxisome-like structures and crystalloid bodies were observed with increasing frequency from 75 days p.c. and 20 days postpartum onward. Polygonal lysosome-like dense bodies transformed into complex membranous structures especially after birth. Giant mitochondria occurred in the late fetal and postnatal period. From 75 days p.c. onward fully developed Leydig cells were scarce in testes of decapitated fetuses. Leydig cell characteristics disappeared toward the end of the fetal period; only the cell shape, the large bundles or whirls of intermediate filaments, some scarce polygonal lysosome-like dense bodies, and RER remained, but SER was negligible. Progressive hemorrhages apparent in situ were correlated positively with fetal age. The dependency of Leydig cells upon LH began between 60 and 75 days postcoitum.

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Section: Discussionsupporting

confidence: 79%

Leydig cell development in the pig testis during the late fetal and early postnatal period: An electron microscopic study with attention to the influence of fetal decapitation

Vorstenbosch¹,

Colenbrander²,

Wensing³

1984

Am. J. Anat.

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“…Contrary to the results of Lederberg (1999), Just et al (2002), Stefan and Steimer (1978), Evdokimov (2013), and Smorkatcheva and Kumaitova (2014) on E. talpinus and E. tancrei, the reproduction potential of E. lutescens was sufficient and the intervals were unsteady. The annual reproductive activity period of E. lutescens was longer than the findings of Coşkun and Ulutürk (2003), Nowak (1995), Evdokimov (2002Evdokimov ( , 2013, and Smorkatcheva and Kumaitova (2014) on E. talpinus and E. tancrei.…”

Section: Discussioncontrasting

confidence: 89%

“…Additionally, it appears that E. lutescens is able to reproduce throughout the year when considering the results of the annual period of reproductive activity of E. lutescens in this study and in that of Coşkun and Ulutürk (2003). The litters throughout the year and their sizes (Table 1) were similar to those reported by Ognev (1963), Coşkun and Ulutürk (2003), Walker (1964), and Stefan and Steimer (1978), but smaller than those of Nowak (1995) as reported for E. lutescens. Annual litters and sizes were smaller than those of E. tancrei (Smorkatcheva and Kumaitova, 2014) and E. talpinus (Evdokimov, 2002).…”

Section: Discussionsupporting

confidence: 83%

“…

Just et al (2002) reported that E. lutescens produces litters inadequately in captivity, but Stefan and Steimer (1978) stated that E. lutescens has a relatively regular reproduction rate in the laboratory. Ognev (1963) found that E. lutescens gave birth to four litters annually, each with 2-4 young; Coşkun and Ulutürk (2003) reported that they gave birth to at least two litters throughout the year having 2-4 pups; Nowak (1995) stated that they produce 6-7 litters annually, each with 3-5 young; Walker (1964) found that E. lutescens can bear 1-7 pups twice a year; and Stefan and Steimer (1978) stated that they produce litters regularly each with 1-4 pups throughout the year. The gestation period of E. lutescens is 26 days and the young reach sexual maturity by 96 days.

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mentioning

confidence: 99%

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Reproduction, postnatal development, and social behavior of Ellobius lutescens Thomas, 1897 (Mammalia: Rodentia) in captivity

Kaya

Coşkun²

2015

Turk J Zool

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Just et al. (2002) reported that E. lutescens produces litters inadequately in captivity, but Stefan and Steimer (1978) stated that E. lutescens has a relatively regular reproduction rate in the laboratory. Ognev (1963) found that E. lutescens gave birth to four litters annually, each with 2-4 young; Coşkun and Ulutürk (2003) reported that they gave birth to at least two litters throughout the year having 2-4 pups; Nowak (1995) stated that they produce 6-7 litters annually, each with 3-5 young; Walker (1964) found that E. lutescens can bear 1-7 pups twice a year; and Stefan and Steimer (1978) stated that they produce litters regularly each with 1-4 pups throughout the year. The gestation period of E. lutescens is 26 days and the young reach sexual maturity by 96 days. The pups stay with parents for 2 months (Nowak, 1995). According to Ognev (1963) and Coşkun and Ulutürk ( 2003), E. lutescens breeds from April to the end of October and in March-April and October-November, respectively.Evdokimov (2013) concluded that the northern mole vole (E. talpinus) has a low reproductive potential. Smorkatcheva and Kumaitova (2014) mentioned that while Zaisan mole voles (E. tancrei) readily breed in captivity, the birth rate is generally low and quite unpredictable, with intervals between litters ranging from 32 days to about 6 months. Evdokimov (2013) reported that sexual maturation in E. talpinus depends on the time of the animal's birth, but most of them matured after the first wintering. The young opened their eyes on days 21-28 and independent feeding was observed on days 20-25. Younglings reach the size of adult animals at an age of 2-3 months. Smorkatcheva and Kumaitova (2014) stated that pups of E. tancrei opened their eyes around days 22-26. Weaning gradually occurred over the next several days. E. tancrei offspring stay in the natal burrow until at least 2-3 months of age. During this period, reproductive females can deliver one or several litters. Female offspring most likely will not breed unless their mother dies. Litter size ranges from 1 to 4 pups. Smorkatcheva and Kumaitova

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“…In a study on this species, the testes were found to weigh only about 20 mg for males of 60 g body weight (Stefan & Steimer, 1978). However, despite this similarity in the occurrence of a very small testis, the structure of the seminiferous epithelium of mole voles and hopping mice was very different.…”

Section: Discussionmentioning

confidence: 93%

Cytological organization of the seminiferous epithelium in the Australian rodents Pseudomys australis and Notomys alexis

Peirce¹,

Breed²

1987

Reproduction

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Absolute and relative testis mass of two species of conilurine rodents, the plains rat (Pseudomys australis) and the hopping mouse (Notomys alexis), were markedly different. In plains rats the testis comprised approximately 3% of body mass while in hopping mice they rarely accounted for more than 0.2%. In both species, 8 cellular associations, or cycle stages, were recognized in the seminiferous epithelium. The relative frequencies, and hence durations, of Stages I to VIII were 5.1, 7.0, 12.5, 10.5, 5.4, 25.9, 4.4 and 29.0% of one cycle for plains rats (N = 14), and 20.4, 10.9, 9.6, 8.1, 5.1, 20.4, 14.7 and 10.8% for laboratory-bred hopping mice (N = 35). Generally, the relative durations of the cycle stages were very similar between plains rat individuals, but were variable between hopping mice. Also, organization of the seminiferous epithelium was less rigid in hopping mouse testes, and several anomalies were observed. These included: the occurrence of 2-4 cellular associations in about 20% (range 11.3-33.9%) of tubular cross-sections, deviations in cellular composition in certain cycle stages from that usually observed, and an increased incidence of degenerating cells, together with the presence of multinucleated "giant' cells, within the seminiferous epithelium.

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The Leydig Cell of a Hypogonadic Rodent (Ellobius lutescens, Th.): Correlation between Ultrastructure and Biosynthetic Activity

Abstract: Adult male

Cited by 6 publications

References 11 publications

Leydig cell development in the pig testis during the late fetal and early postnatal period: An electron microscopic study with attention to the influence of fetal decapitation

Leydig cell development in the pig testis during the late fetal and early postnatal period: An electron microscopic study with attention to the influence of fetal decapitation

Reproduction, postnatal development, and social behavior of Ellobius lutescens Thomas, 1897 (Mammalia: Rodentia) in captivity

Cytological organization of the seminiferous epithelium in the Australian rodents Pseudomys australis and Notomys alexis

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