The levels of plasma and salivary antioxidants in the patient with recurrent aphthous stomatitis

Abstract

Since we found salivary SOD and CAT levels were high whereas plasma levels were low, it has been thought that, salivary defence mechanisms via antioxidant agents may be stimulated against to the ulcerous lesion. We consider that the organism might mobilize the antioxidant potential to the sites where they were needed. At this point, decrease of SOD and CAT levels in the plasma may be related to this shift. It is also thought that GSHPx secretion in the saliva may also be increased but the increase in its turnover may be responsible for the diminished activity.

Orally administrated rare earth element cerium induces metallothionein synthesis and increases glutathione in the mouse liver

“…This phenomenon seems likely that the plasma SOD activity is influenced by the antioxidant system comprises antioxidant enzymes such as catalase and glutathione peroxidase, and non-enzymatic defenses like lipid-soluble vitamins and water-soluble vitamins. This result agrees with the two reports (Rui et al, 2004;Karincaoglu et al, 2005), and indicates the need for future studies of SOD mechanisms. Metallothioneins (MTs) are metal binding, low molecular mass proteins with a very high cysteine content.…”

Recurrent aphthous stomatitis

“…The role of antioxidants in RAS is still attracting attention because blood and salivary levels of antioxidants such as erythrocyte superoxide dismutase and catalase seem to be higher in patients with RAS and Behçet's syndrome than in normal controls [67][68][69] , but their causative roles in RAS are yet to be clearly defined. There have also been several reported cases of drug-induced RAS.…”

Assessment of salivary and serum antioxidant status in patients with recurrent aphthous stomatitis

“…Accordingly, mammalian cells have developed complicated antioxidant defense systems to prevent oxidative damage and to allow survival in an aerobic environment. This system includes enzymatic activities such as erythrocyte superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx), blood antioxidant molecules as well as non-enzymatic antioxidants including vitamins A,C, E melatonin, and uric acid (UA) (5)(6)(7)(8). It has been reported in few studies that impaired oxidant/ antioxidant balance is responsible for the tissue damage in RAS patients (7)(8)(9).…”

“…This system includes enzymatic activities such as erythrocyte superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx), blood antioxidant molecules as well as non-enzymatic antioxidants including vitamins A,C, E melatonin, and uric acid (UA) (5)(6)(7)(8). It has been reported in few studies that impaired oxidant/ antioxidant balance is responsible for the tissue damage in RAS patients (7)(8)(9). Regarding the insufficient studies pertinent to this issue, the aim of the present study was to measure some parameters of oxidative stress including erythrocyte superoxide dismutase, catalase, glutathione peroxidase, and the level of salivary and blood oxidant/antioxidant status of RAS patients and compare it with healthy subjects to find new information about RAS aetiopathology.…”