Orally administrated rare earth element cerium induces metallothionein synthesis and increases glutathione in the mouse liver

Effect of Cadmium on Lipid Peroxidation and on Some Antioxidants in the Liver, Kidneys and Testes of Rats Given Diet Containing Cadmium-polluted Radish Bulbs

“…The results of the present study showed that throughout the experimental period, the highest concentrations of Cd were observed in the liver, followed by the kidney and the testis. This is in agreement with some previous studies that have reported that cadmium is concentrated mainly in the liver 19 , 20 . However it should be noted that the differences in the cadmium concentrations in the liver and kidney decrease as the duration of treatment increases.…”

“…This excludes the possibility of an oxidative nature of this metal in the liver tissue. This confirms the work of Shibutani et al 25 and Kawagoe et al 19 carried out respectively in rats and mice, which showed that cadmium decreases lipid peroxidation in the liver of these animals. In contrast, other studies have reported an increase in lipid peroxidation in the liver under the influence of Cd 25 , 26 .…”

“…Kawagoe et al 19 also showed that cadmium increases hepatic GSH levels. The increase in GSH levels may be a result of high transcriptional regulation of γ-glutamylcysteine synthetase, the enzyme that is responsible for the synthesis of GSH 27 .…”

Effect of Cadmium on Lipid Peroxidation and on Some Antioxidants in the Liver, Kidneys and Testes of Rats Given Diet Containing Cadmium-polluted Radish Bulbs

“…The results of the present study showed that throughout the experimental period, the highest concentrations of Cd were observed in the liver, followed by the kidney and the testis. This is in agreement with some previous studies that have reported that cadmium is concentrated mainly in the liver 19 , 20 . However it should be noted that the differences in the cadmium concentrations in the liver and kidney decrease as the duration of treatment increases.…”

“…This excludes the possibility of an oxidative nature of this metal in the liver tissue. This confirms the work of Shibutani et al 25 and Kawagoe et al 19 carried out respectively in rats and mice, which showed that cadmium decreases lipid peroxidation in the liver of these animals. In contrast, other studies have reported an increase in lipid peroxidation in the liver under the influence of Cd 25 , 26 .…”

“…Kawagoe et al 19 also showed that cadmium increases hepatic GSH levels. The increase in GSH levels may be a result of high transcriptional regulation of γ-glutamylcysteine synthetase, the enzyme that is responsible for the synthesis of GSH 27 .…”

Effects of Dietary Rare Earth Chitosan Chelate on Performance, Egg Quality, Immune and Antioxidant Capacity, and Intestinal Digestive Enzyme Activity of Laying Hens

“…The SOD activity in serum showed a downward trend at a low dosage of dietary RECC inclusion. Similarly, the same effects were observable when REEs was supplemented in the diets of fish or poultry species [37,42,43]. It may be due to the multiple effects of the antioxidant enzymes (CAT, GSH-Px, etc.)…”

Synchrotron XRF Analysis Identifies Cerium Accumulation Colocalized with Pharyngeal Deformities in CeO2 NP-Exposed Caenorhabditis elegans

“…Similar to the CeO 2 NPs, the exposure to Ce(NO 3 ) 3 led to an increase in the antioxidant defense gene sod-1 ; however, no further increases in the ROS or cellular redox status were observed ( Figures S9–S11 ). Kawagoe et al 48 previously reported an oxidative stress response in the mouse liver, in terms of increased metallothionein synthesis and glutathione levels, following the exposure to Ce 3+ , accompanied by significantly decreased growth, fertility, and reproduction. In the current study, increasing concentrations lead to a statistically significant ( p < 0.05, Tukey’s HSD) reduction in reproduction ( Figure S5 ), coupled with a consistent significantly increased sod-1 gene expression ( Figure S9 ).…”

Effect of Cadmium on Lipid Peroxidation and on Some Antioxidants in the Liver, Kidneys and Testes of Rats Given Diet Containing Cadmium-polluted Radish Bulbs

“…The results of the present study showed that throughout the experimental period, the highest concentrations of Cd were observed in the liver, followed by the kidney and the testis. This is in agreement with some previous studies that have reported that cadmium is concentrated mainly in the liver 19 , 20 . However it should be noted that the differences in the cadmium concentrations in the liver and kidney decrease as the duration of treatment increases.…”

“…This excludes the possibility of an oxidative nature of this metal in the liver tissue. This confirms the work of Shibutani et al 25 and Kawagoe et al 19 carried out respectively in rats and mice, which showed that cadmium decreases lipid peroxidation in the liver of these animals. In contrast, other studies have reported an increase in lipid peroxidation in the liver under the influence of Cd 25 , 26 .…”

“…Kawagoe et al 19 also showed that cadmium increases hepatic GSH levels. The increase in GSH levels may be a result of high transcriptional regulation of γ-glutamylcysteine synthetase, the enzyme that is responsible for the synthesis of GSH 27 .…”

Effects of Dietary Rare Earth Chitosan Chelate on Performance, Egg Quality, Immune and Antioxidant Capacity, and Intestinal Digestive Enzyme Activity of Laying Hens

“…The SOD activity in serum showed a downward trend at a low dosage of dietary RECC inclusion. Similarly, the same effects were observable when REEs was supplemented in the diets of fish or poultry species [37,42,43]. It may be due to the multiple effects of the antioxidant enzymes (CAT, GSH-Px, etc.)…”

Synchrotron XRF Analysis Identifies Cerium Accumulation Colocalized with Pharyngeal Deformities in CeO2 NP-Exposed Caenorhabditis elegans

“…Similar to the CeO 2 NPs, the exposure to Ce(NO 3 ) 3 led to an increase in the antioxidant defense gene sod-1 ; however, no further increases in the ROS or cellular redox status were observed ( Figures S9–S11 ). Kawagoe et al 48 previously reported an oxidative stress response in the mouse liver, in terms of increased metallothionein synthesis and glutathione levels, following the exposure to Ce 3+ , accompanied by significantly decreased growth, fertility, and reproduction. In the current study, increasing concentrations lead to a statistically significant ( p < 0.05, Tukey’s HSD) reduction in reproduction ( Figure S5 ), coupled with a consistent significantly increased sod-1 gene expression ( Figure S9 ).…”

Effect of Cadmium on Lipid Peroxidation and on Some Antioxidants in the Liver, Kidneys and Testes of Rats Given Diet Containing Cadmium-polluted Radish Bulbs

“…The results of the present study showed that throughout the experimental period, the highest concentrations of Cd were observed in the liver, followed by the kidney and the testis. This is in agreement with some previous studies that have reported that cadmium is concentrated mainly in the liver 19 , 20 . However it should be noted that the differences in the cadmium concentrations in the liver and kidney decrease as the duration of treatment increases.…”

“…This excludes the possibility of an oxidative nature of this metal in the liver tissue. This confirms the work of Shibutani et al 25 and Kawagoe et al 19 carried out respectively in rats and mice, which showed that cadmium decreases lipid peroxidation in the liver of these animals. In contrast, other studies have reported an increase in lipid peroxidation in the liver under the influence of Cd 25 , 26 .…”

“…Kawagoe et al 19 also showed that cadmium increases hepatic GSH levels. The increase in GSH levels may be a result of high transcriptional regulation of γ-glutamylcysteine synthetase, the enzyme that is responsible for the synthesis of GSH 27 .…”

Effects of Dietary Rare Earth Chitosan Chelate on Performance, Egg Quality, Immune and Antioxidant Capacity, and Intestinal Digestive Enzyme Activity of Laying Hens

“…The SOD activity in serum showed a downward trend at a low dosage of dietary RECC inclusion. Similarly, the same effects were observable when REEs was supplemented in the diets of fish or poultry species [37,42,43]. It may be due to the multiple effects of the antioxidant enzymes (CAT, GSH-Px, etc.)…”

Synchrotron XRF Analysis Identifies Cerium Accumulation Colocalized with Pharyngeal Deformities in CeO2 NP-Exposed Caenorhabditis elegans

“…Similar to the CeO 2 NPs, the exposure to Ce(NO 3 ) 3 led to an increase in the antioxidant defense gene sod-1 ; however, no further increases in the ROS or cellular redox status were observed ( Figures S9–S11 ). Kawagoe et al 48 previously reported an oxidative stress response in the mouse liver, in terms of increased metallothionein synthesis and glutathione levels, following the exposure to Ce 3+ , accompanied by significantly decreased growth, fertility, and reproduction. In the current study, increasing concentrations lead to a statistically significant ( p < 0.05, Tukey’s HSD) reduction in reproduction ( Figure S5 ), coupled with a consistent significantly increased sod-1 gene expression ( Figure S9 ).…”