The level of the serum opsonin, mannan-binding protein in HIV-1 antibody-positive patients

Abstract

SUMMARYThe concentrations of mannan-binding protein (MBP) in consecutive samples from 10 HIV* persons were estimated using an ELISA based on polyclonal rahbit anti-MBP. The changes in MBP with time were similar in HIV^ and HIV" persons, and did not appear to be of clinical significance. MBP was determined in a further 70 persons found HIV-1 ^ during a period af 25 years (1984)(1985)(1986). Out of the total of 80 patients, 32 have by now died from AIDS. According to the serum level of MBP the HIV-infected persons were grouped into high (>65Qng MBP/ml). intermediate (101-650 ng/ml), and low MBP (< 101 ng/ml). At the termination of the study the frequency of deaths/total in each of the groups were: high MBP, 14/39 (36%); intermediate MBP. 12/26 (46%); and low MBP, 6/14 (43%). There was no association between the MBP level of the individual and the progressive loss of CD4* T cells, and the level of MBP was not predictive for the length of time between the detection of HIV antibodies and development of AIDS, nor for the duration of AIDS before death occurred. The number of HIV ' persons without detectable MBP (10%) was significantly higher than previously reported for healthy persons (2 4%, P = 0 027). The course of HIV infection does not seem to be influenced by the level of MBP. nor does the antimicrobial activity of MBP appear to affect the progression of AIDS. Further studies are required to substantiate the significance of absenee of MBP in the susceptibility to HIV.

HIV-1 Disease Progression and Survival in an Adult Population in Zimbabwe: Is There an Effect of the Mannose Binding Lectin Deficiency?

“…Plasma MBL deficiency and MBL2 genetic variants had no role in HIV disease progression in our study population defined as decrease in CD4 + T cell count and increase in viral load, in accord with other findings (Catano et al, 2008;Nielsen et al, 1995;Senaldi et al, 1995) but in contrast to other reports of a significant association Hundt et al, 2000;Tan et al, 2009;Vallinoto et al, 2008). The studies that showed similar results to ours were done in the USA among those with European origins and African Americans (Catano et al, 2008), UK (Senaldi et al, 1995), and Denmark (Nielsen et al, 1995). Studies that showed contrasting results to ours were done in Denmark , China (Tan et al, 2009), Germany (Hundt et al, 2000), and Brazil (Vallinoto et al, 2008).…”

“…Available literature on association between MBL deficiency and HIV disease progression is conflicting, with some reporting faster HIV disease progression among those with MBL deficiency Hundt et al, 2000;Tan et al, 2009;Vallinoto et al, 2008) but others have reported no association (Catano et al, 2008;Nielsen et al, 1995;Senaldi et al, 1995). Presence of an association between MBL deficiency and decreased survival in HIV infected people has been reported , but conflictingly others reported increased survival in those with variant MBL2 genotypes and MBL deficient individuals (Maas et al, 1998), where MBL deficiency was reported to confer protection.…”

Characterization of mannose-binding lectin plasma levels and genetic polymorphisms in HIV-1-infected individuals

“…Several studies have verified that MBL deficiency increases susceptibility to HIV-1 infection or affects the process of infection 9,[19][20][21] . In the present study, the comparative analysis of genotype frequencies between the two groups revealed only a slightly higher prevalence of the MBL*O variant in HIV-1-seropositive patients compared to the healthy controls, while the allele and genotype differences were not significant.…”

Characterization of polymorphisms in the mannose-binding lectin gene promoter among human immunodeficiency virus 1 infected subjects

“…This suggests a possible predisposition to HIV-1 infection due to the high frequency of HIV-infected subjects carrying the allele L in homozygous form, but no significant differences in the frequencies of alleles, haplotypes or genotypes among HIV-1-infected and uninfected subjects was reported. Nielsen et al (1995) and Pastinen et al (1998) have shown that HIV-1-infected subjects presented lower serum levels of MBL compared to uninfected subjects and, according to Mangano et al (2008), MBL plasma concentration is associated with the rate of AIDS progression when considering vertical transmission of the virus. This model was not supported by Senaldi et al (1999).…”