Characterization of polymorphisms in the mannose-binding lectin gene promoter among human immunodeficiency virus 1 infected subjects

Abstract

The present study investigated the prevalence of mutations in the -550 (H/L) and -221 (X/Y) mannose-binding lectin (MBL) gene promoter regions and their impact on infection by human immunodeficiency virus 1 (HIV-

HIV-1 Disease Progression and Survival in an Adult Population in Zimbabwe: Is There an Effect of the Mannose Binding Lectin Deficiency?

“…Plasma MBL concentration was not a predictor of HIV status, CD4 + T cell count, and viral load. Plasma MBL deficiency and MBL2 genetic variants had no role in HIV disease progression in our study population defined as decrease in CD4 + T cell count and increase in viral load, in accord with other findings (Catano et al, 2008;Nielsen et al, 1995;Senaldi et al, 1995) but in contrast to other reports of a significant association Hundt et al, 2000;Tan et al, 2009;Vallinoto et al, 2008). The studies that showed similar results to ours were done in the USA among those with European origins and African Americans (Catano et al, 2008), UK (Senaldi et al, 1995), and Denmark (Nielsen et al, 1995).…”

“…The studies that showed similar results to ours were done in the USA among those with European origins and African Americans (Catano et al, 2008), UK (Senaldi et al, 1995), and Denmark (Nielsen et al, 1995). Studies that showed contrasting results to ours were done in Denmark , China (Tan et al, 2009), Germany (Hundt et al, 2000), and Brazil (Vallinoto et al, 2008). The possible reasons why our results are different to others who found an association between MBL deficiency and disease progression might be due to differences in characteristics of the different populations studied or might be due to differences in sample sizes used.…”

“…The possible reasons why our results are different to others who found an association between MBL deficiency and disease progression might be due to differences in characteristics of the different populations studied or might be due to differences in sample sizes used. Our sample size was 198 HIV-positive male and female participants compared to analysis in 96 HIV-positive homosexual men , 128 HIV positive adult males and females (Vallinoto et al, 2008), 1075 adult males and females (Tan et al, 2009), and only 6 long-term HIV positive non-progressors (Hundt et al, 2000).…”

“…Mannose Binding Lectin (MBL), an important constituent of the innate immune system, has been widely investigated in different populations to determine association between MBL deficiency and susceptibility to several other infections (Antony et al, 2013;Hu et al, 2010;Zinyama-Gutsire et al, 2015) and the role of MBL deficiency in HIV disease progression (Boniotto et al, 2000;Catano et al, 2008;Hundt et al, 2000;Maas et al, 1998;Mangano et al, 2008;Prohaszka et al, 1997;Senaldi et al, 1995;Tan et al, 2009;Vallinoto et al, 2008) and survival Maas et al, 1998).…”

Mannose-binding lectin and susceptibility to human retrovirus infections

“…The prevalence of mutations in the -550 (H/L) and -221 (X/Y) MBL gene promoter regions and their impact on HIV-1 infection were investigated in a population of 128 HIV-1 seropositive and 97 seronegative individuals, and there were no differences in the allele and haplotype frequencies between seropositive and seronegative status 9 . CD4 + T-lymphocyte counts were lower in the seropositive individuals carrying haplotypes LY, LX, and HX, as compared to those carrying the HY haplotype.…”