The level of serotonin in the superficial masseter muscle in relation to local pain and allodynia

Ernberg, Malin; Hedenberg-Magnusson, Britt; Alstergren, Per; Kopp, Sigvard

doi:10.1016/s0024-3205(99)00250-7

Cited by 89 publications

(66 citation statements)

References 19 publications

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“…Intramuscular administration of 5-HT into the human masseter muscle has been demonstrated to induce pain (Ernberg et al, 2006). The studies identified in this systematic review concerning chronic trapezius myalgia (Table 1) clearly indicate significantly increased levels of 5-HT in the whole spectrum of severity of chronic trapezius myalgia and these findings agree with other studies of muscle pain conditions such as myalgic masseter muscle (Ernberg et al, 1999) (Table 4) and chronic whiplash associated pain including trapezius pain (Gerdle et al, 2008c) ( Table 2). The finding that there are higher interstitial levels of 5-HT in chronic trapezius myalgia than in controls at rest agrees with other studies that also found that 5-HT is a peripheral pro-nociceptive substance activated by afferents and by the release of other substances (Saria et al, 1990;Sommer, 2004).…”

Section: Serotoninsupporting

confidence: 88%

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Potential Muscle Biomarkers of Chronic Myalgia in Humans - A Systematic Review of Microdialysis Studies

Gerdle¹,

Larsson²

2012

Biomarker

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Section: Serotoninsupporting

confidence: 88%

“…Compared to the healthy controls, fibromyalgia patients had increased 5-HT in the masseter muscle (Ernberg et al, 1999). Compared to the healthy controls, myofascial temporomandibular disorder patients had significantly higher glutamate levels (Castrillon et al, 2010) (Table 4 …”

Section: Temporomandibular Pain Disordersmentioning

confidence: 99%

Potential Muscle Biomarkers of Chronic Myalgia in Humans - A Systematic Review of Microdialysis Studies

Gerdle¹,

Larsson²

2012

Biomarker

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“…This finding has never been reported in studies regarding autism. Interestingly, the association between serotoninemia and pain threshold was also found in subjects with temporomandibular joint pain [16][17][18]. These findings fall within research on the key role of the serotoninergic system in the descending cortical control of nociceptive processing [19].…”

Section: Discussionmentioning

confidence: 69%

Pain reactivity in children with autistic disorder

Militerni¹,

Bravaccio²,

Falco³

et al. 2000

J Headache Pain

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Abnormal pain reactivity is often reported by the parents of children with autistic disorder (AD). This is an interesting feature because it could be related to some neurochemical findings frequently reported in autism. The aim of the present study is to report the preliminary findings about pain reactivity in children with autism, and to relate them to serotoninemia. We studied 77 subjects with “primary” AD. Reports of each child's pain reactivity were obtained through a structured interview with the child's parent. In 44 of the 77 children, serotonin blood levels were measured. We found an abnormal pain reactivity in children with autistic disorder when compared with non-autistic children, matched for age, sex, and socio-economic level. The pain reactivity showed a significant correlation with the serotoninemia levels. The data obtained by the present study are interesting, although they must be considered with careful attention, both for the sample size and for methodological difficulties. In fact, in studying this disorder, only the parents' insight can be of help

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“…Exposure to both natural and artificial light may have positive effects on mood in healthy and depressed individuals (Beauchemin et al, 1990;Partonen et al, 2000;Yamada et al, 1995) and has been associated with reduced mortality in cardiovascular and cancer patients (Beauchemin et al, 1998;Lefkowitz et al, 1994;Freedman et al, 2002). Light exposure may impact pain by increasing serotonin levels in the body (Ernberg et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Pain in its environmental context: Implications for designing environments to enhance pain control

Malenbaum

Keefe

Williams

et al. 2008

Pain

136

101

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There has recently been heightened recognition that environmental factors can influence pain. Clinicians involved in delivering multidisciplinary pain programs often structure the social environment of their treatment settings to help promote adaptive responses to pain. Recent theories of pain (e.g. Craig, 2003, Melzack, 1999, Fields & Basbaum, 1999 highlight the role that sensory stimuli from the environment can play in influencing the pain experience.Despite the awareness if the environment's influence on pain, patients with pain continue to be treated in settings that are devoid of distracting stimuli. The typical treatment room is painted white, lacking decoration, sparsely furnished, and windowless. Patient's auditory stimuli may range from the noise generated by overhead lighting to urgent, loud paging requests, to sounds of other patients suffering. The visual and sensory settings in which we usually treat pain patients probably do little to relieve pain and may exacerbate pain. This paper considers the influence of environmental stimuli including light, nature scenes and sounds, and video and virtual reality (VR) stimuli on pain and examines the implications for designing pain treatment environments to enhance pain control. Literature Review LightLight is an integral part of any building and can vary according to time of day, location of the structure, window number and style, and numerous other structural and environmental elements. Light influences people in the building and available evidence suggests that exposure to light has implications for pain experiences. Walch et al. (2005) recently conducted a prospective study testing the effects of exposure to sunlight on pain medication in 89 patients who had undergone spine surgery. Patients were randomly assigned to a bright or dim room in the hospital. Bright rooms were exposed to 46% more natural light than dim rooms. Patients in the bright rooms required 22% less opioidequivalent analgesic medications which resulted in 21% decrease in medication costs. Bright room patients reported significantly greater decreases in stress and marginally significant decreases in pain. The fact that recovering in a room with more natural light lowered medication intake is noteworthy, particularly since lower medication intake is associated with fewer side effects and lower costs.Exposure to light may enhance recovery from painful medical conditions. Beauchemin and Hays (1998) conducted a retrospective study that examined the impact of natural light exposure Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers

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The level of serotonin in the superficial masseter muscle in relation to local pain and allodynia

Cited by 89 publications

References 19 publications

Potential Muscle Biomarkers of Chronic Myalgia in Humans - A Systematic Review of Microdialysis Studies

Potential Muscle Biomarkers of Chronic Myalgia in Humans - A Systematic Review of Microdialysis Studies

Pain reactivity in children with autistic disorder

Pain in its environmental context: Implications for designing environments to enhance pain control

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